COVID-19 on Oral Health: A New Bilateral Connection for the Pandemic
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and transmission are generally known to be produced by respiratory droplets and aerosols from the oral cavity (O.C.) of infected subjects, as stated by the World Health Organization. Saliva also retains the viral particles and ai...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/12/1/60 |
| _version_ | 1797340108460916736 |
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| author | Luigi Bellocchio Gianna Dipalma Angelo Michele Inchingolo Alessio Danilo Inchingolo Laura Ferrante Gaetano Del Vecchio Giuseppina Malcangi Andrea Palermo Andis Qendro Francesco Inchingolo |
| author_facet | Luigi Bellocchio Gianna Dipalma Angelo Michele Inchingolo Alessio Danilo Inchingolo Laura Ferrante Gaetano Del Vecchio Giuseppina Malcangi Andrea Palermo Andis Qendro Francesco Inchingolo |
| author_sort | Luigi Bellocchio |
| collection | DOAJ |
| description | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and transmission are generally known to be produced by respiratory droplets and aerosols from the oral cavity (O.C.) of infected subjects, as stated by the World Health Organization. Saliva also retains the viral particles and aids in the spread of COVID-19. Angiotensin-converting enzyme Type 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) are two of the numerous factors that promote SARS-CoV-2 infection, expressed by O.C. structures, various mucosa types, and the epithelia of salivary glands. A systemic SARS-CoV-2 infection might result from viral replication in O.C. cells. On the other hand, cellular damage of different subtypes in the O.C. might be associated with various clinical signs and symptoms. Factors interfering with SARS-CoV-2 infection potential might represent fertile ground for possible local pharmacotherapeutic interventions, which may confine SARS-CoV-2 virus entry and transmission in the O.C., finally representing a way to reduce COVID-19 incidence and severity. |
| first_indexed | 2024-03-08T09:58:12Z |
| format | Article |
| id | doaj.art-d491a6355d9d4bb691c3593b846ed9ac |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-08T09:58:12Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-d491a6355d9d4bb691c3593b846ed9ac2024-01-29T13:46:49ZengMDPI AGBiomedicines2227-90592023-12-011216010.3390/biomedicines12010060COVID-19 on Oral Health: A New Bilateral Connection for the PandemicLuigi Bellocchio0Gianna Dipalma1Angelo Michele Inchingolo2Alessio Danilo Inchingolo3Laura Ferrante4Gaetano Del Vecchio5Giuseppina Malcangi6Andrea Palermo7Andis Qendro8Francesco Inchingolo9INSERM, U1215 NeuroCentre Magendie, Endocannabinoids and Neuroadaptation, University of Bordeaux, 33063 Bordeaux, FranceDepartment of Interdisciplinary Medicine, University of Study “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, University of Study “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, University of Study “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, University of Study “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, University of Study “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, University of Study “Aldo Moro”, 70124 Bari, ItalyCollege of Medicine and Dentistry, Birmingham B4 6BN, UKFaculty of Dental Medicine, University of Medicine, 1005 Tirana, AlbaniaDepartment of Interdisciplinary Medicine, University of Study “Aldo Moro”, 70124 Bari, ItalySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and transmission are generally known to be produced by respiratory droplets and aerosols from the oral cavity (O.C.) of infected subjects, as stated by the World Health Organization. Saliva also retains the viral particles and aids in the spread of COVID-19. Angiotensin-converting enzyme Type 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) are two of the numerous factors that promote SARS-CoV-2 infection, expressed by O.C. structures, various mucosa types, and the epithelia of salivary glands. A systemic SARS-CoV-2 infection might result from viral replication in O.C. cells. On the other hand, cellular damage of different subtypes in the O.C. might be associated with various clinical signs and symptoms. Factors interfering with SARS-CoV-2 infection potential might represent fertile ground for possible local pharmacotherapeutic interventions, which may confine SARS-CoV-2 virus entry and transmission in the O.C., finally representing a way to reduce COVID-19 incidence and severity.https://www.mdpi.com/2227-9059/12/1/60COVID-19SARS-CoV-2saliva transmissionrespiratory syndromeinfectionoral cavity (O.C.) |
| spellingShingle | Luigi Bellocchio Gianna Dipalma Angelo Michele Inchingolo Alessio Danilo Inchingolo Laura Ferrante Gaetano Del Vecchio Giuseppina Malcangi Andrea Palermo Andis Qendro Francesco Inchingolo COVID-19 on Oral Health: A New Bilateral Connection for the Pandemic Biomedicines COVID-19 SARS-CoV-2 saliva transmission respiratory syndrome infection oral cavity (O.C.) |
| title | COVID-19 on Oral Health: A New Bilateral Connection for the Pandemic |
| title_full | COVID-19 on Oral Health: A New Bilateral Connection for the Pandemic |
| title_fullStr | COVID-19 on Oral Health: A New Bilateral Connection for the Pandemic |
| title_full_unstemmed | COVID-19 on Oral Health: A New Bilateral Connection for the Pandemic |
| title_short | COVID-19 on Oral Health: A New Bilateral Connection for the Pandemic |
| title_sort | covid 19 on oral health a new bilateral connection for the pandemic |
| topic | COVID-19 SARS-CoV-2 saliva transmission respiratory syndrome infection oral cavity (O.C.) |
| url | https://www.mdpi.com/2227-9059/12/1/60 |
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