Percutaneous electrical nerve field stimulation compared to standard medical therapy in adolescents with functional abdominal pain disorders
IntroductionStandard medical therapy (SMT) in children with functional abdominal pain disorders (FAPD) includes cyproheptadine and amitriptyline. While percutaneous electrical nerve field stimulation (PENFS) has shown benefit, no study has compared outcomes of PENFS to SMT. We aimed to examine chang...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Pain Research |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpain.2023.1251932/full |
| _version_ | 1797681400550260736 |
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| author | Neha R. Santucci Neha R. Santucci Rashmi Sahay Khalil I. El-Chammas Khalil I. El-Chammas Kahleb Graham Kahleb Graham Mikaela Wheatley Mikaela Wheatley Madeleine Vandenbrink Jennifer Hardy Lin Fei |
| author_facet | Neha R. Santucci Neha R. Santucci Rashmi Sahay Khalil I. El-Chammas Khalil I. El-Chammas Kahleb Graham Kahleb Graham Mikaela Wheatley Mikaela Wheatley Madeleine Vandenbrink Jennifer Hardy Lin Fei |
| author_sort | Neha R. Santucci |
| collection | DOAJ |
| description | IntroductionStandard medical therapy (SMT) in children with functional abdominal pain disorders (FAPD) includes cyproheptadine and amitriptyline. While percutaneous electrical nerve field stimulation (PENFS) has shown benefit, no study has compared outcomes of PENFS to SMT. We aimed to examine changes in abdominal pain, nausea and disability before and after treatment and compare outcomes between treatments.MethodsThe records of FAPD patients ages 11–21 years, treated with 4 weeks of PENFS, cyproheptadine or amitriptyline were reviewed. Outcomes were evaluated using validated questionnaires [Abdominal Pain Index (API), Nausea Severity Scale (NSS), and the Functional Disability Inventory (FDI)] at baseline and follow-up within 3 months (FU).ResultOf 101 patients, 48% received PENFS, 31% cyproheptadine and 21% received amitriptyline. Median ages were 17 (15–19), 16 (15–18) and 15 (11–16) years respectively and the majority were females (75%, 90% and 52% respectively). In the PENFS group, API (p = 0.001), NSS (p = 0.059) and FDI (p = 0.048) were significantly lower at FU. API (p = 0.034) but not NSS and FDI (p > 0.05) decreased significantly at FU in the amitriptyline group. API, NSS and FDI did not change significantly with cyproheptadine at FU (p > 0.05). FU API scores were lower in PENFS vs. cyproheptadine (p = 0.04) but not vs. amitriptyline (p = 0.64). The FDI scores were significantly lower in the amitriptyline vs. cyproheptadine group (p = 0.03).ConclusionTherapy with PENFS showed improvements in abdominal pain, nausea and disability while amitriptyline showed improvements in abdominal pain within 3 months of treatment. PENFS was more effective than cyproheptadine in improving abdominal pain. Amitriptyline improved disability scores more than cyproheptadine and showed promise for treatment. PENFS may be a good non-pharmacologic alternative for FAPD. |
| first_indexed | 2024-03-11T23:44:24Z |
| format | Article |
| id | doaj.art-d494dec128284210a70250304155d6de |
| institution | Directory Open Access Journal |
| issn | 2673-561X |
| language | English |
| last_indexed | 2024-03-11T23:44:24Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pain Research |
| spelling | doaj.art-d494dec128284210a70250304155d6de2023-09-19T15:04:56ZengFrontiers Media S.A.Frontiers in Pain Research2673-561X2023-09-01410.3389/fpain.2023.12519321251932Percutaneous electrical nerve field stimulation compared to standard medical therapy in adolescents with functional abdominal pain disordersNeha R. Santucci0Neha R. Santucci1Rashmi Sahay2Khalil I. El-Chammas3Khalil I. El-Chammas4Kahleb Graham5Kahleb Graham6Mikaela Wheatley7Mikaela Wheatley8Madeleine Vandenbrink9Jennifer Hardy10Lin Fei11Gastroenterology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United StatesPediatrics, University of Cincinnati, Cincinnati, OH, United StatesBiostatistics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United StatesGastroenterology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United StatesPediatrics, University of Cincinnati, Cincinnati, OH, United StatesGastroenterology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United StatesPediatrics, University of Cincinnati, Cincinnati, OH, United StatesGastroenterology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United StatesPediatrics, University of Cincinnati, Cincinnati, OH, United StatesPediatrics, University of Cincinnati, Cincinnati, OH, United StatesGastroenterology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United StatesBiostatistics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United StatesIntroductionStandard medical therapy (SMT) in children with functional abdominal pain disorders (FAPD) includes cyproheptadine and amitriptyline. While percutaneous electrical nerve field stimulation (PENFS) has shown benefit, no study has compared outcomes of PENFS to SMT. We aimed to examine changes in abdominal pain, nausea and disability before and after treatment and compare outcomes between treatments.MethodsThe records of FAPD patients ages 11–21 years, treated with 4 weeks of PENFS, cyproheptadine or amitriptyline were reviewed. Outcomes were evaluated using validated questionnaires [Abdominal Pain Index (API), Nausea Severity Scale (NSS), and the Functional Disability Inventory (FDI)] at baseline and follow-up within 3 months (FU).ResultOf 101 patients, 48% received PENFS, 31% cyproheptadine and 21% received amitriptyline. Median ages were 17 (15–19), 16 (15–18) and 15 (11–16) years respectively and the majority were females (75%, 90% and 52% respectively). In the PENFS group, API (p = 0.001), NSS (p = 0.059) and FDI (p = 0.048) were significantly lower at FU. API (p = 0.034) but not NSS and FDI (p > 0.05) decreased significantly at FU in the amitriptyline group. API, NSS and FDI did not change significantly with cyproheptadine at FU (p > 0.05). FU API scores were lower in PENFS vs. cyproheptadine (p = 0.04) but not vs. amitriptyline (p = 0.64). The FDI scores were significantly lower in the amitriptyline vs. cyproheptadine group (p = 0.03).ConclusionTherapy with PENFS showed improvements in abdominal pain, nausea and disability while amitriptyline showed improvements in abdominal pain within 3 months of treatment. PENFS was more effective than cyproheptadine in improving abdominal pain. Amitriptyline improved disability scores more than cyproheptadine and showed promise for treatment. PENFS may be a good non-pharmacologic alternative for FAPD.https://www.frontiersin.org/articles/10.3389/fpain.2023.1251932/fullneurostimulationamitriptylinecyproheptadinepediatricschronic abdominal pain |
| spellingShingle | Neha R. Santucci Neha R. Santucci Rashmi Sahay Khalil I. El-Chammas Khalil I. El-Chammas Kahleb Graham Kahleb Graham Mikaela Wheatley Mikaela Wheatley Madeleine Vandenbrink Jennifer Hardy Lin Fei Percutaneous electrical nerve field stimulation compared to standard medical therapy in adolescents with functional abdominal pain disorders Frontiers in Pain Research neurostimulation amitriptyline cyproheptadine pediatrics chronic abdominal pain |
| title | Percutaneous electrical nerve field stimulation compared to standard medical therapy in adolescents with functional abdominal pain disorders |
| title_full | Percutaneous electrical nerve field stimulation compared to standard medical therapy in adolescents with functional abdominal pain disorders |
| title_fullStr | Percutaneous electrical nerve field stimulation compared to standard medical therapy in adolescents with functional abdominal pain disorders |
| title_full_unstemmed | Percutaneous electrical nerve field stimulation compared to standard medical therapy in adolescents with functional abdominal pain disorders |
| title_short | Percutaneous electrical nerve field stimulation compared to standard medical therapy in adolescents with functional abdominal pain disorders |
| title_sort | percutaneous electrical nerve field stimulation compared to standard medical therapy in adolescents with functional abdominal pain disorders |
| topic | neurostimulation amitriptyline cyproheptadine pediatrics chronic abdominal pain |
| url | https://www.frontiersin.org/articles/10.3389/fpain.2023.1251932/full |
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