Association Between Serum Neurofilament Light Chain and Cognitive Performance Among Older Adults in the United States: A Cross-Sectional Study
Abstract Introduction Serum neurofilament light chain (sNfL) is an emerging biomarker of neuronal damage in several neurological disorders. Its association with cognitive function in the general US population aged 60 years and above is unknown. The aim of this study was to investigate the correlatio...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2023-10-01
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| Series: | Neurology and Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s40120-023-00555-9 |
| _version_ | 1797629920761872384 |
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| author | Yuanyuan Gao Dan Su Zhouya Xue Lin Ji Shu Wang |
| author_facet | Yuanyuan Gao Dan Su Zhouya Xue Lin Ji Shu Wang |
| author_sort | Yuanyuan Gao |
| collection | DOAJ |
| description | Abstract Introduction Serum neurofilament light chain (sNfL) is an emerging biomarker of neuronal damage in several neurological disorders. Its association with cognitive function in the general US population aged 60 years and above is unknown. The aim of this study was to investigate the correlation between sNfL and cognitive function in the general US population aged 60 and above. Methods The data were obtained from the 2013–2014 National Health and Nutrition Examination Survey (NHANES), which include 506 individuals aged 60 or older who met our search criteria. In our study, sNfL levels were divided into two groups based on dichotomization (19.0 pg/mL). After adjusting for multiple covariates, it was found that the high sNfL group (≥ 19.0 pg/mL) had lower cognitive performance than the low sNfL group (< 19.0 pg/mL). This relationship was also stable in subgroup analysis. Conclusion In this sample of an American elderly population, higher sNfL levels are correlated with lower cognitive performance. Our findings suggest that sNfL may become a potential screening tool for early prediction and confirmation of cognitive damage. |
| first_indexed | 2024-03-11T11:00:35Z |
| format | Article |
| id | doaj.art-d495697224a74672a07685d3db08fd91 |
| institution | Directory Open Access Journal |
| issn | 2193-8253 2193-6536 |
| language | English |
| last_indexed | 2024-03-11T11:00:35Z |
| publishDate | 2023-10-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Neurology and Therapy |
| spelling | doaj.art-d495697224a74672a07685d3db08fd912023-11-12T12:34:14ZengAdis, Springer HealthcareNeurology and Therapy2193-82532193-65362023-10-011262147216010.1007/s40120-023-00555-9Association Between Serum Neurofilament Light Chain and Cognitive Performance Among Older Adults in the United States: A Cross-Sectional StudyYuanyuan Gao0Dan Su1Zhouya Xue2Lin Ji3Shu Wang4Affiliated Hospital Six of Nantong University, Yancheng Third People’s HospitalAffiliated Hospital Six of Nantong University, Yancheng Third People’s HospitalThe First People’s Hospital of YanchengAffiliated Hospital Six of Nantong University, Yancheng Third People’s HospitalAffiliated Hospital Six of Nantong University, Yancheng Third People’s HospitalAbstract Introduction Serum neurofilament light chain (sNfL) is an emerging biomarker of neuronal damage in several neurological disorders. Its association with cognitive function in the general US population aged 60 years and above is unknown. The aim of this study was to investigate the correlation between sNfL and cognitive function in the general US population aged 60 and above. Methods The data were obtained from the 2013–2014 National Health and Nutrition Examination Survey (NHANES), which include 506 individuals aged 60 or older who met our search criteria. In our study, sNfL levels were divided into two groups based on dichotomization (19.0 pg/mL). After adjusting for multiple covariates, it was found that the high sNfL group (≥ 19.0 pg/mL) had lower cognitive performance than the low sNfL group (< 19.0 pg/mL). This relationship was also stable in subgroup analysis. Conclusion In this sample of an American elderly population, higher sNfL levels are correlated with lower cognitive performance. Our findings suggest that sNfL may become a potential screening tool for early prediction and confirmation of cognitive damage.https://doi.org/10.1007/s40120-023-00555-9Alzheimer's diseaseCerebrospinal fluidCognitive performanceNeurofilament light chainSerum neurofilament light chain |
| spellingShingle | Yuanyuan Gao Dan Su Zhouya Xue Lin Ji Shu Wang Association Between Serum Neurofilament Light Chain and Cognitive Performance Among Older Adults in the United States: A Cross-Sectional Study Neurology and Therapy Alzheimer's disease Cerebrospinal fluid Cognitive performance Neurofilament light chain Serum neurofilament light chain |
| title | Association Between Serum Neurofilament Light Chain and Cognitive Performance Among Older Adults in the United States: A Cross-Sectional Study |
| title_full | Association Between Serum Neurofilament Light Chain and Cognitive Performance Among Older Adults in the United States: A Cross-Sectional Study |
| title_fullStr | Association Between Serum Neurofilament Light Chain and Cognitive Performance Among Older Adults in the United States: A Cross-Sectional Study |
| title_full_unstemmed | Association Between Serum Neurofilament Light Chain and Cognitive Performance Among Older Adults in the United States: A Cross-Sectional Study |
| title_short | Association Between Serum Neurofilament Light Chain and Cognitive Performance Among Older Adults in the United States: A Cross-Sectional Study |
| title_sort | association between serum neurofilament light chain and cognitive performance among older adults in the united states a cross sectional study |
| topic | Alzheimer's disease Cerebrospinal fluid Cognitive performance Neurofilament light chain Serum neurofilament light chain |
| url | https://doi.org/10.1007/s40120-023-00555-9 |
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