Innate immunity and metal ion trafficking pathway perturbations in idiopathic Parkinson's disease and Tuberculosis: A comparative transcriptomics approach
Introduction: The purpose of our study is to detect and compare common, significantly enriched pathways in peripheral blood mononuclears (PBMC) and CNS tissue donated by idiopathic Parkinson's Disease (iPD) patients and compare their transcriptomic profiles with those donated by tuberculosis (T...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-12-01
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| Series: | Brain Disorders |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S266645932100024X |
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| author | George D. Vavougios Sotirios Zarogiannis Debmalya Barh Marianthi Breza Karen A. Krogfelt George Stamoulis Konstantinos I. Gourgoulianis |
| author_facet | George D. Vavougios Sotirios Zarogiannis Debmalya Barh Marianthi Breza Karen A. Krogfelt George Stamoulis Konstantinos I. Gourgoulianis |
| author_sort | George D. Vavougios |
| collection | DOAJ |
| description | Introduction: The purpose of our study is to detect and compare common, significantly enriched pathways in peripheral blood mononuclears (PBMC) and CNS tissue donated by idiopathic Parkinson's Disease (iPD) patients and compare their transcriptomic profiles with those donated by tuberculosis (TB) patients. Methods: We performed comparative transcriptomic analyses between gene expression studies published in the GEO Datasets repository, retrieved as queries of iPD and TB each vs healthy controls. Results: Datasets retrieved involved iPD: 2 PBMC studies, 1 Substantia Nigra (SN) and 1 Dorsal Motor Nucleus of the Vagus (DMNV) study, as well as TB: 1 PBMC and one study with monocyte (Mc) gene expression profiles. Among significantly enriched pathways were the influenza A (IAV) associated “Viral mRNA Translation” and “L13a-mediated translational silencing of Ceruloplasmin expression”, common between DMNV, active Tb Monocytes (TBA Mc), post-treatment TB and both iPD PBMC datasets. Discussion: Our results support the hypothesis that remnant, postinfectious epigenetic changes on PBMCs inflicted by Mycobacterium Tuberculosis (Mtb) may alter their phenotype, facilitating non-abortive intracellular residency for a subsequent pathogen. This pathogen may be transmissible to the CNS via sites such as the vagal projections, and prime iPD pathogenesis by disrupting metal ion homeostasis in a lifecycle – dependent manner. |
| first_indexed | 2024-12-17T21:16:38Z |
| format | Article |
| id | doaj.art-d49716d6f86c42049248b0c394e57a24 |
| institution | Directory Open Access Journal |
| issn | 2666-4593 |
| language | English |
| last_indexed | 2024-12-17T21:16:38Z |
| publishDate | 2021-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Disorders |
| spelling | doaj.art-d49716d6f86c42049248b0c394e57a242022-12-21T21:32:19ZengElsevierBrain Disorders2666-45932021-12-014100025Innate immunity and metal ion trafficking pathway perturbations in idiopathic Parkinson's disease and Tuberculosis: A comparative transcriptomics approachGeorge D. Vavougios0Sotirios Zarogiannis1Debmalya Barh2Marianthi Breza3Karen A. Krogfelt4George Stamoulis5Konstantinos I. Gourgoulianis6Department of Neurology, Athens Naval Hospital, Deinokratous 70, 115 21 Athens, Greece; Department of Respiratory Medicine, Faculty of Medicine, University of Thessaly, BIOPOLIS, Mezourlo, 41110 Larisa, Greece; Department of Neurology, Medical School, University of Cyprus, Nicosia, Cyprus; Corresponding author at: Athens Naval Hospital, Deinokratous 70, 115 21.Department of Pleural Physiology, Faculty of Medicine, University of Thessaly, BIOPOLIS, Mezourlo, 41500 Larisa, GreeceCentre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, WB, India1st Department of Neurology, Eginition Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, GreeceDepartment of Science and Environment, Molecular and Medical Biology, Roskilde University, Universitetsvej 1, 28A.1, DK-4000 Roskilde, DenmarkDepartment of Electrical and Computer Engineering, 37 Glavani – 28th October Street, Deligiorgi Building, 4th floor, 382 21 Volos, GreeceDepartment of Respiratory Medicine, Faculty of Medicine, University of Thessaly, BIOPOLIS, Mezourlo, 41110 Larisa, GreeceIntroduction: The purpose of our study is to detect and compare common, significantly enriched pathways in peripheral blood mononuclears (PBMC) and CNS tissue donated by idiopathic Parkinson's Disease (iPD) patients and compare their transcriptomic profiles with those donated by tuberculosis (TB) patients. Methods: We performed comparative transcriptomic analyses between gene expression studies published in the GEO Datasets repository, retrieved as queries of iPD and TB each vs healthy controls. Results: Datasets retrieved involved iPD: 2 PBMC studies, 1 Substantia Nigra (SN) and 1 Dorsal Motor Nucleus of the Vagus (DMNV) study, as well as TB: 1 PBMC and one study with monocyte (Mc) gene expression profiles. Among significantly enriched pathways were the influenza A (IAV) associated “Viral mRNA Translation” and “L13a-mediated translational silencing of Ceruloplasmin expression”, common between DMNV, active Tb Monocytes (TBA Mc), post-treatment TB and both iPD PBMC datasets. Discussion: Our results support the hypothesis that remnant, postinfectious epigenetic changes on PBMCs inflicted by Mycobacterium Tuberculosis (Mtb) may alter their phenotype, facilitating non-abortive intracellular residency for a subsequent pathogen. This pathogen may be transmissible to the CNS via sites such as the vagal projections, and prime iPD pathogenesis by disrupting metal ion homeostasis in a lifecycle – dependent manner.http://www.sciencedirect.com/science/article/pii/S266645932100024XParkinson's diseaseTuberculosisMycobacteriaPathway EnrichmentSystems Biology |
| spellingShingle | George D. Vavougios Sotirios Zarogiannis Debmalya Barh Marianthi Breza Karen A. Krogfelt George Stamoulis Konstantinos I. Gourgoulianis Innate immunity and metal ion trafficking pathway perturbations in idiopathic Parkinson's disease and Tuberculosis: A comparative transcriptomics approach Brain Disorders Parkinson's disease Tuberculosis Mycobacteria Pathway Enrichment Systems Biology |
| title | Innate immunity and metal ion trafficking pathway perturbations in idiopathic Parkinson's disease and Tuberculosis: A comparative transcriptomics approach |
| title_full | Innate immunity and metal ion trafficking pathway perturbations in idiopathic Parkinson's disease and Tuberculosis: A comparative transcriptomics approach |
| title_fullStr | Innate immunity and metal ion trafficking pathway perturbations in idiopathic Parkinson's disease and Tuberculosis: A comparative transcriptomics approach |
| title_full_unstemmed | Innate immunity and metal ion trafficking pathway perturbations in idiopathic Parkinson's disease and Tuberculosis: A comparative transcriptomics approach |
| title_short | Innate immunity and metal ion trafficking pathway perturbations in idiopathic Parkinson's disease and Tuberculosis: A comparative transcriptomics approach |
| title_sort | innate immunity and metal ion trafficking pathway perturbations in idiopathic parkinson s disease and tuberculosis a comparative transcriptomics approach |
| topic | Parkinson's disease Tuberculosis Mycobacteria Pathway Enrichment Systems Biology |
| url | http://www.sciencedirect.com/science/article/pii/S266645932100024X |
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