An Eye on Kupffer Cells: Development, Phenotype and the Macrophage Niche
Macrophages are key participants in the maintenance of tissue homeostasis under normal and pathological conditions, and implement a rich diversity of functions. The largest population of resident tissue macrophages is found in the liver. Hepatic macrophages, termed Kupffer cells, are involved in the...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-08-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/17/9868 |
| _version_ | 1797495217822105600 |
|---|---|
| author | Andrey Elchaninov Polina Vishnyakova Egor Menyailo Gennady Sukhikh Timur Fatkhudinov |
| author_facet | Andrey Elchaninov Polina Vishnyakova Egor Menyailo Gennady Sukhikh Timur Fatkhudinov |
| author_sort | Andrey Elchaninov |
| collection | DOAJ |
| description | Macrophages are key participants in the maintenance of tissue homeostasis under normal and pathological conditions, and implement a rich diversity of functions. The largest population of resident tissue macrophages is found in the liver. Hepatic macrophages, termed Kupffer cells, are involved in the regulation of multiple liver functionalities. Specific differentiation profiles and functional activities of tissue macrophages have been attributed to the shaping role of the so-called tissue niche microenvironments. The fundamental macrophage niche concept was lately shaken by a flood of new data, leading to a revision and substantial update of the concept, which constitutes the main focus of this review. The macrophage community discusses contemporary evidence on the developmental origins of resident macrophages, notably Kupffer cells and the issues of heterogeneity of the hepatic macrophage populations, as well as the roles of proliferation, cell death and migration processes in the maintenance of macrophage populations of the liver. Special consideration is given to interactions of Kupffer cells with other local cell lineages, including Ito cells, sinusoidal endothelium and hepatocytes, which participate in the maintenance of their phenotypical and functional identity. |
| first_indexed | 2024-03-10T01:44:40Z |
| format | Article |
| id | doaj.art-d497197081b947a7bd5b950b01876bde |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T01:44:40Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d497197081b947a7bd5b950b01876bde2023-11-23T13:18:29ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-08-012317986810.3390/ijms23179868An Eye on Kupffer Cells: Development, Phenotype and the Macrophage NicheAndrey Elchaninov0Polina Vishnyakova1Egor Menyailo2Gennady Sukhikh3Timur Fatkhudinov4Laboratory of Regenerative Medicine, National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov of Ministry of Healthcare of Russian Federation, 117997 Moscow, RussiaLaboratory of Regenerative Medicine, National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov of Ministry of Healthcare of Russian Federation, 117997 Moscow, RussiaLaboratory of Growth and Development, Avtsyn Research Institute of Human Morphology of FSBI “Petrovsky National Research Centre of Surgery”, 117418 Moscow, RussiaLaboratory of Regenerative Medicine, National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov of Ministry of Healthcare of Russian Federation, 117997 Moscow, RussiaHistology Department, Medical Institute, Peoples’ Friendship University of Russia, 117198 Moscow, RussiaMacrophages are key participants in the maintenance of tissue homeostasis under normal and pathological conditions, and implement a rich diversity of functions. The largest population of resident tissue macrophages is found in the liver. Hepatic macrophages, termed Kupffer cells, are involved in the regulation of multiple liver functionalities. Specific differentiation profiles and functional activities of tissue macrophages have been attributed to the shaping role of the so-called tissue niche microenvironments. The fundamental macrophage niche concept was lately shaken by a flood of new data, leading to a revision and substantial update of the concept, which constitutes the main focus of this review. The macrophage community discusses contemporary evidence on the developmental origins of resident macrophages, notably Kupffer cells and the issues of heterogeneity of the hepatic macrophage populations, as well as the roles of proliferation, cell death and migration processes in the maintenance of macrophage populations of the liver. Special consideration is given to interactions of Kupffer cells with other local cell lineages, including Ito cells, sinusoidal endothelium and hepatocytes, which participate in the maintenance of their phenotypical and functional identity.https://www.mdpi.com/1422-0067/23/17/9868macrophagesmonocytesmacrophage nicheKupffer cellsIto cellsendothelial cells |
| spellingShingle | Andrey Elchaninov Polina Vishnyakova Egor Menyailo Gennady Sukhikh Timur Fatkhudinov An Eye on Kupffer Cells: Development, Phenotype and the Macrophage Niche International Journal of Molecular Sciences macrophages monocytes macrophage niche Kupffer cells Ito cells endothelial cells |
| title | An Eye on Kupffer Cells: Development, Phenotype and the Macrophage Niche |
| title_full | An Eye on Kupffer Cells: Development, Phenotype and the Macrophage Niche |
| title_fullStr | An Eye on Kupffer Cells: Development, Phenotype and the Macrophage Niche |
| title_full_unstemmed | An Eye on Kupffer Cells: Development, Phenotype and the Macrophage Niche |
| title_short | An Eye on Kupffer Cells: Development, Phenotype and the Macrophage Niche |
| title_sort | eye on kupffer cells development phenotype and the macrophage niche |
| topic | macrophages monocytes macrophage niche Kupffer cells Ito cells endothelial cells |
| url | https://www.mdpi.com/1422-0067/23/17/9868 |
| work_keys_str_mv | AT andreyelchaninov aneyeonkupffercellsdevelopmentphenotypeandthemacrophageniche AT polinavishnyakova aneyeonkupffercellsdevelopmentphenotypeandthemacrophageniche AT egormenyailo aneyeonkupffercellsdevelopmentphenotypeandthemacrophageniche AT gennadysukhikh aneyeonkupffercellsdevelopmentphenotypeandthemacrophageniche AT timurfatkhudinov aneyeonkupffercellsdevelopmentphenotypeandthemacrophageniche AT andreyelchaninov eyeonkupffercellsdevelopmentphenotypeandthemacrophageniche AT polinavishnyakova eyeonkupffercellsdevelopmentphenotypeandthemacrophageniche AT egormenyailo eyeonkupffercellsdevelopmentphenotypeandthemacrophageniche AT gennadysukhikh eyeonkupffercellsdevelopmentphenotypeandthemacrophageniche AT timurfatkhudinov eyeonkupffercellsdevelopmentphenotypeandthemacrophageniche |