Hepatitis A: Viral Structure, Classification, Life Cycle, Clinical Symptoms, Diagnosis Error, and Vaccination
Hepatitis A virus (HAV) is one of the well-known viruses that cause hepatitis all around the globe. Although this illness has decreased in developed countries due to extensive immunization, numerous developing and under-developed countries are struggling with this virus. HAV infection can be spread...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Hindawi Limited
2023-01-01
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| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2023/4263309 |
| _version_ | 1826993065590521856 |
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| author | Omid Gholizadeh Sama Akbarzadeh Mohamad Ghazanfari Hashemi Marjan Gholami Parya Amini Zahra Yekanipour Raheleh Tabatabaie Saman Yasamineh Parastoo Hosseini Vahdat Poortahmasebi |
| author_facet | Omid Gholizadeh Sama Akbarzadeh Mohamad Ghazanfari Hashemi Marjan Gholami Parya Amini Zahra Yekanipour Raheleh Tabatabaie Saman Yasamineh Parastoo Hosseini Vahdat Poortahmasebi |
| author_sort | Omid Gholizadeh |
| collection | DOAJ |
| description | Hepatitis A virus (HAV) is one of the well-known viruses that cause hepatitis all around the globe. Although this illness has decreased in developed countries due to extensive immunization, numerous developing and under-developed countries are struggling with this virus. HAV infection can be spread by oral-fecal contact, and there are frequent epidemics through nutrition. Improvements in socioeconomic and sanitary circumstances have caused a shift in the disease’s prevalence worldwide. Younger children are usually asymptomatic, but as they become older, the infection symptoms begin to appear. Symptoms range from slight inflammation and jaundice to acute liver failure in older individuals. While an acute infection may be self-limiting, unrecognized persistent infections, and the misapplication of therapeutic methods based on clinical guidelines are linked to a higher incidence of cirrhosis, hepatocellular carcinoma, and mortality. Fortunately, most patients recover within two months of infection, though 10–15% of patients will relapse within the first six months. A virus seldom leads to persistent infection or liver damage. The mainstay of therapy is based on supportive care. All children from 12–23 months, as well as some susceptible populations, should receive routine vaccinations, according to the Centers for Disease Control and Prevention and the American Academy of Pediatrics. Laboratory diagnosis of HAV is based on antigen detection, checking liver enzyme levels, and antibody screening. Furthermore, polymerase chain reaction (PCR) technology has identified HAV in suspected nutrition sources; therefore, this technique is used for preventative measures and food-related laws. |
| first_indexed | 2024-04-10T22:43:19Z |
| format | Article |
| id | doaj.art-d4977ead46cf4d7a8ada8391290f6cdd |
| institution | Directory Open Access Journal |
| issn | 1918-1493 |
| language | English |
| last_indexed | 2025-02-18T08:58:13Z |
| publishDate | 2023-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj.art-d4977ead46cf4d7a8ada8391290f6cdd2024-11-02T23:54:01ZengHindawi LimitedCanadian Journal of Infectious Diseases and Medical Microbiology1918-14932023-01-01202310.1155/2023/4263309Hepatitis A: Viral Structure, Classification, Life Cycle, Clinical Symptoms, Diagnosis Error, and VaccinationOmid Gholizadeh0Sama Akbarzadeh1Mohamad Ghazanfari Hashemi2Marjan Gholami3Parya Amini4Zahra Yekanipour5Raheleh Tabatabaie6Saman Yasamineh7Parastoo Hosseini8Vahdat Poortahmasebi9Department of Bacteriology and VirologyDepartment of Animal BiologyDepartment of RadiologyDepartment of PharmacyDepartment of MicrobiologyInfectious and Tropical Diseases Research CenterDepartment of ImmunologyInfectious and Tropical Diseases Research CenterDepartment of VirologyDepartment of Bacteriology and VirologyHepatitis A virus (HAV) is one of the well-known viruses that cause hepatitis all around the globe. Although this illness has decreased in developed countries due to extensive immunization, numerous developing and under-developed countries are struggling with this virus. HAV infection can be spread by oral-fecal contact, and there are frequent epidemics through nutrition. Improvements in socioeconomic and sanitary circumstances have caused a shift in the disease’s prevalence worldwide. Younger children are usually asymptomatic, but as they become older, the infection symptoms begin to appear. Symptoms range from slight inflammation and jaundice to acute liver failure in older individuals. While an acute infection may be self-limiting, unrecognized persistent infections, and the misapplication of therapeutic methods based on clinical guidelines are linked to a higher incidence of cirrhosis, hepatocellular carcinoma, and mortality. Fortunately, most patients recover within two months of infection, though 10–15% of patients will relapse within the first six months. A virus seldom leads to persistent infection or liver damage. The mainstay of therapy is based on supportive care. All children from 12–23 months, as well as some susceptible populations, should receive routine vaccinations, according to the Centers for Disease Control and Prevention and the American Academy of Pediatrics. Laboratory diagnosis of HAV is based on antigen detection, checking liver enzyme levels, and antibody screening. Furthermore, polymerase chain reaction (PCR) technology has identified HAV in suspected nutrition sources; therefore, this technique is used for preventative measures and food-related laws.http://dx.doi.org/10.1155/2023/4263309 |
| spellingShingle | Omid Gholizadeh Sama Akbarzadeh Mohamad Ghazanfari Hashemi Marjan Gholami Parya Amini Zahra Yekanipour Raheleh Tabatabaie Saman Yasamineh Parastoo Hosseini Vahdat Poortahmasebi Hepatitis A: Viral Structure, Classification, Life Cycle, Clinical Symptoms, Diagnosis Error, and Vaccination Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | Hepatitis A: Viral Structure, Classification, Life Cycle, Clinical Symptoms, Diagnosis Error, and Vaccination |
| title_full | Hepatitis A: Viral Structure, Classification, Life Cycle, Clinical Symptoms, Diagnosis Error, and Vaccination |
| title_fullStr | Hepatitis A: Viral Structure, Classification, Life Cycle, Clinical Symptoms, Diagnosis Error, and Vaccination |
| title_full_unstemmed | Hepatitis A: Viral Structure, Classification, Life Cycle, Clinical Symptoms, Diagnosis Error, and Vaccination |
| title_short | Hepatitis A: Viral Structure, Classification, Life Cycle, Clinical Symptoms, Diagnosis Error, and Vaccination |
| title_sort | hepatitis a viral structure classification life cycle clinical symptoms diagnosis error and vaccination |
| url | http://dx.doi.org/10.1155/2023/4263309 |
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