Bridging the gap between emerging models and humans by learning from polio animal studies: A systematic review
Abstract Disease modelling plays a fundamental role in biomedical research, even more in virology where the virus depends strictly on its host for replication. Although animal models are extensively used in virology, there is an increasing demand for animal‐free research. Therefore, during this tran...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-06-01
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| Series: | Clinical and Translational Discovery |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ctd2.42 |
| _version_ | 1797945499489140736 |
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| author | Giulia Moreni Ikrame Aknouch Morris Ras Lieke Brouwer René Spijker Carlemi Calitz Koert J. Stittelaar Adithya Sridhar Katja C. Wolthers Dasja Pajkrt |
| author_facet | Giulia Moreni Ikrame Aknouch Morris Ras Lieke Brouwer René Spijker Carlemi Calitz Koert J. Stittelaar Adithya Sridhar Katja C. Wolthers Dasja Pajkrt |
| author_sort | Giulia Moreni |
| collection | DOAJ |
| description | Abstract Disease modelling plays a fundamental role in biomedical research, even more in virology where the virus depends strictly on its host for replication. Although animal models are extensively used in virology, there is an increasing demand for animal‐free research. Therefore, during this transition, it is crucial to learn and take advantage of animal research to better implement new emerging models. In this study, we aim to systematically review the translation from animal models to humans for the well‐characterized viral disease polio, as a reference for novel in vitro models in virology. We found a high risk of bias in the included studies and a large diversity of animal models. Moreover, we showed that animal models for studying poliovirus pathogenesis are mainly discrimination models focusing on specific aspects of the disease allowing an insightful understanding of the complex poliovirus infection. Our review underlines the importance of proper standardization of new emerging models and a careful interpretation of the results from discrimination models. |
| first_indexed | 2024-04-10T20:56:05Z |
| format | Article |
| id | doaj.art-d4995a7846e44029b329068fa786f57a |
| institution | Directory Open Access Journal |
| issn | 2768-0622 |
| language | English |
| last_indexed | 2024-04-10T20:56:05Z |
| publishDate | 2022-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Discovery |
| spelling | doaj.art-d4995a7846e44029b329068fa786f57a2023-01-23T05:21:29ZengWileyClinical and Translational Discovery2768-06222022-06-0122n/an/a10.1002/ctd2.42Bridging the gap between emerging models and humans by learning from polio animal studies: A systematic reviewGiulia Moreni0Ikrame Aknouch1Morris Ras2Lieke Brouwer3René Spijker4Carlemi Calitz5Koert J. Stittelaar6Adithya Sridhar7Katja C. Wolthers8Dasja Pajkrt9Department of Medical Microbiology Academic Medical Center OrganoVIR Labs Amsterdam University Medical Centers Amsterdam The NetherlandsDepartment of Medical Microbiology Academic Medical Center OrganoVIR Labs Amsterdam University Medical Centers Amsterdam The NetherlandsDepartment of Medical Microbiology Academic Medical Center OrganoVIR Labs Amsterdam University Medical Centers Amsterdam The NetherlandsDepartment of Medical Microbiology Academic Medical Center OrganoVIR Labs Amsterdam University Medical Centers Amsterdam The NetherlandsAmsterdam University Medical Centers Academic Medical Center Medical Library University of Amsterdam Amsterdam The NetherlandsDepartment of Medical Microbiology Academic Medical Center OrganoVIR Labs Amsterdam University Medical Centers Amsterdam The NetherlandsDepartment of Epidemiology Bioinformatics and Animal Models Wageningen Bioveterinary Research Wageningen University Lelystad The NetherlandsDepartment of Medical Microbiology Academic Medical Center OrganoVIR Labs Amsterdam University Medical Centers Amsterdam The NetherlandsDepartment of Medical Microbiology Academic Medical Center OrganoVIR Labs Amsterdam University Medical Centers Amsterdam The NetherlandsDepartment of Medical Microbiology Academic Medical Center OrganoVIR Labs Amsterdam University Medical Centers Amsterdam The NetherlandsAbstract Disease modelling plays a fundamental role in biomedical research, even more in virology where the virus depends strictly on its host for replication. Although animal models are extensively used in virology, there is an increasing demand for animal‐free research. Therefore, during this transition, it is crucial to learn and take advantage of animal research to better implement new emerging models. In this study, we aim to systematically review the translation from animal models to humans for the well‐characterized viral disease polio, as a reference for novel in vitro models in virology. We found a high risk of bias in the included studies and a large diversity of animal models. Moreover, we showed that animal models for studying poliovirus pathogenesis are mainly discrimination models focusing on specific aspects of the disease allowing an insightful understanding of the complex poliovirus infection. Our review underlines the importance of proper standardization of new emerging models and a careful interpretation of the results from discrimination models.https://doi.org/10.1002/ctd2.42biomedical translationexperimental modelspoliovirusvirology |
| spellingShingle | Giulia Moreni Ikrame Aknouch Morris Ras Lieke Brouwer René Spijker Carlemi Calitz Koert J. Stittelaar Adithya Sridhar Katja C. Wolthers Dasja Pajkrt Bridging the gap between emerging models and humans by learning from polio animal studies: A systematic review Clinical and Translational Discovery biomedical translation experimental models poliovirus virology |
| title | Bridging the gap between emerging models and humans by learning from polio animal studies: A systematic review |
| title_full | Bridging the gap between emerging models and humans by learning from polio animal studies: A systematic review |
| title_fullStr | Bridging the gap between emerging models and humans by learning from polio animal studies: A systematic review |
| title_full_unstemmed | Bridging the gap between emerging models and humans by learning from polio animal studies: A systematic review |
| title_short | Bridging the gap between emerging models and humans by learning from polio animal studies: A systematic review |
| title_sort | bridging the gap between emerging models and humans by learning from polio animal studies a systematic review |
| topic | biomedical translation experimental models poliovirus virology |
| url | https://doi.org/10.1002/ctd2.42 |
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