LncRNA GAS5 suppresses TGF-β1-induced transformation of pulmonary pericytes into myofibroblasts by recruiting KDM5B and promoting H3K4me2/3 demethylation of the PDGFRα/β promoter

LncRNA GAS5 suppresses TGF-β1-induced transformation of pulmonary pericytes into myofibroblasts by recruiting KDM5B and promoting H3K4me2/3 demethylation of the PDGFRα/β promoter

Abstract Background Idiopathic pulmonary fibrosis (IPF) is a condition that may cause persistent pulmonary damage. The transformation of pericytes into myofibroblasts has been recognized as a key player during IPF progression. This study aimed to investigate the functions of lncRNA growth arrest-spe...

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Bibliographic Details
Main Authors: Yichun Wang, Diyu Chen, Han Xie, Shuhua Zhou, Mingwang Jia, Xiaobo He, Feifei Guo, Yihuan Lai, Xiao Xiao Tang
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Molecular Medicine
Subjects:
GAS5
Idiopathic pulmonary fibrosis
PDGFRα/β
Myofibroblasts
Online Access:https://doi.org/10.1186/s10020-023-00620-x

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