Maternal and neonatal risk factors of asthma in children: Nationwide population based study
Background: Small population group-based cohorts have found that perinatal factors may contribute to the development of asthma in children. We aimed to investigate maternal and neonatal risk factors for the asthma phenotypes using two databases from the Taiwan's Maternal and Child Health Databa...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-02-01
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| Series: | Journal of Microbiology, Immunology and Infection |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S168411822200189X |
| _version_ | 1797936405579563008 |
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| author | Chuang-Ming Wang Shun-Ting Yang Cheng-Chia Yang Hsiao-Yu Chiu Hsiang-Yu Lin Ming-Luen Tsai Hung-Chih Lin Yu-Chia Chang |
| author_facet | Chuang-Ming Wang Shun-Ting Yang Cheng-Chia Yang Hsiao-Yu Chiu Hsiang-Yu Lin Ming-Luen Tsai Hung-Chih Lin Yu-Chia Chang |
| author_sort | Chuang-Ming Wang |
| collection | DOAJ |
| description | Background: Small population group-based cohorts have found that perinatal factors may contribute to the development of asthma in children. We aimed to investigate maternal and neonatal risk factors for the asthma phenotypes using two databases from the Taiwan's Maternal and Child Health Database (TMCHD) and the National Health Insurance Research Database (NHIRD). Methods: Perinatal data was obtained from 2004 to 2008 in the TMCHD and linked the NHIRD to obtain relevant medical information regarding maternal and neonatal risk factors of three asthma phenotypes which were identified as transient early asthma, persistent asthma, and late-onset asthma. A multivariate logistic regression analysis was conducted to adjust for covariates. Results: The percentage of non-asthmatic patients was 77.02% and asthmatic (transient early asthma, late onset asthma, and persistent asthma) patients were 8.96%, 11.64%, and 2.42%, respectively. Maternal risk factors—including Cesarean section, maternal asthma, maternal allergic rhinitis (AR), and premature rupture of membranes—and neonatal risk factors, such as male gender, gestational age 29–37 weeks, ventilator use, antibiotics use, AR, and atopic dermatitis, were associated with the development of these three asthma phenotypes. Twins and a gestational age of 28 weeks or less premature were associated with the development of transient early asthma and persistent asthma, but not late onset asthma. Triplets and above were associated with the development of transient early asthma, but not late onset or persistent asthma. Conclusion: Various asthma phenotypes have different risk factors; therefore, their distinct risk factors should be identified in order to early diagnosis and treatment. |
| first_indexed | 2024-04-10T18:30:19Z |
| format | Article |
| id | doaj.art-d49b07738e8243778af0b0cec2bb5015 |
| institution | Directory Open Access Journal |
| issn | 1684-1182 |
| language | English |
| last_indexed | 2024-04-10T18:30:19Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Microbiology, Immunology and Infection |
| spelling | doaj.art-d49b07738e8243778af0b0cec2bb50152023-02-02T04:47:50ZengElsevierJournal of Microbiology, Immunology and Infection1684-11822023-02-01561182191Maternal and neonatal risk factors of asthma in children: Nationwide population based studyChuang-Ming Wang0Shun-Ting Yang1Cheng-Chia Yang2Hsiao-Yu Chiu3Hsiang-Yu Lin4Ming-Luen Tsai5Hung-Chih Lin6Yu-Chia Chang7Department of Pediatrics, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi City 60002, TaiwanDepartment of Pediatrics, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi City 60002, TaiwanDepartment of Healthcare Administration, College of Medical and Health Science, Asia University, Taichung 41354, TaiwanDivision of Neonatology, China Medical University Children's Hospital, China Medical University, Taichung 40402, TaiwanDivision of Neonatology, China Medical University Children's Hospital, China Medical University, Taichung 40402, TaiwanDivision of Neonatology, China Medical University Children's Hospital, China Medical University, Taichung 40402, TaiwanDivision of Neonatology, China Medical University Children's Hospital, China Medical University, Taichung 40402, Taiwan; School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan; Asia University Hospital, Asia University, Taichung 41354, Taiwan; Corresponding author. Division of Neonatology, China Medical University Children's Hospital, China Medical University, Taichung, Taiwan.Department of Healthcare Administration, College of Medical and Health Science, Asia University, Taichung 41354, Taiwan; Department of Long Term Care, College of Health and Nursing, National Quemoy University, Kinmen County 892009, Taiwan; Corresponding author. Department of Long Term Care, College of Health and Nursing, National Quemoy University, Kinmen County, Taiwan / No. 1, University Rd., Jinning Township, Kinmen County 892009, Taiwan.Background: Small population group-based cohorts have found that perinatal factors may contribute to the development of asthma in children. We aimed to investigate maternal and neonatal risk factors for the asthma phenotypes using two databases from the Taiwan's Maternal and Child Health Database (TMCHD) and the National Health Insurance Research Database (NHIRD). Methods: Perinatal data was obtained from 2004 to 2008 in the TMCHD and linked the NHIRD to obtain relevant medical information regarding maternal and neonatal risk factors of three asthma phenotypes which were identified as transient early asthma, persistent asthma, and late-onset asthma. A multivariate logistic regression analysis was conducted to adjust for covariates. Results: The percentage of non-asthmatic patients was 77.02% and asthmatic (transient early asthma, late onset asthma, and persistent asthma) patients were 8.96%, 11.64%, and 2.42%, respectively. Maternal risk factors—including Cesarean section, maternal asthma, maternal allergic rhinitis (AR), and premature rupture of membranes—and neonatal risk factors, such as male gender, gestational age 29–37 weeks, ventilator use, antibiotics use, AR, and atopic dermatitis, were associated with the development of these three asthma phenotypes. Twins and a gestational age of 28 weeks or less premature were associated with the development of transient early asthma and persistent asthma, but not late onset asthma. Triplets and above were associated with the development of transient early asthma, but not late onset or persistent asthma. Conclusion: Various asthma phenotypes have different risk factors; therefore, their distinct risk factors should be identified in order to early diagnosis and treatment.http://www.sciencedirect.com/science/article/pii/S168411822200189XAsthmaChildrenAsthma phenotypeNeonatal risk and maternal risk |
| spellingShingle | Chuang-Ming Wang Shun-Ting Yang Cheng-Chia Yang Hsiao-Yu Chiu Hsiang-Yu Lin Ming-Luen Tsai Hung-Chih Lin Yu-Chia Chang Maternal and neonatal risk factors of asthma in children: Nationwide population based study Journal of Microbiology, Immunology and Infection Asthma Children Asthma phenotype Neonatal risk and maternal risk |
| title | Maternal and neonatal risk factors of asthma in children: Nationwide population based study |
| title_full | Maternal and neonatal risk factors of asthma in children: Nationwide population based study |
| title_fullStr | Maternal and neonatal risk factors of asthma in children: Nationwide population based study |
| title_full_unstemmed | Maternal and neonatal risk factors of asthma in children: Nationwide population based study |
| title_short | Maternal and neonatal risk factors of asthma in children: Nationwide population based study |
| title_sort | maternal and neonatal risk factors of asthma in children nationwide population based study |
| topic | Asthma Children Asthma phenotype Neonatal risk and maternal risk |
| url | http://www.sciencedirect.com/science/article/pii/S168411822200189X |
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