High-sensitivity troponins after a standardized 2-hour treadmill run
Background: The aim of this study was to examine highsensitivity troponin T and I (hsTnT and hsTnI) after a treadmill run under laboratory conditions and to find a possible connection with echocardiographic, laboratory and other assessed parameters. Methods: Nineteen trained men underwent a standard...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Society of Medical Biochemists of Serbia, Belgrade
2018-01-01
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| Series: | Journal of Medical Biochemistry |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2018/1452-82581803364B.pdf |
| _version_ | 1818990431831064576 |
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| author | Broz Pavel Rajdl Daniel Novak Jaroslav Hromadka Milan Racek Jaroslav Trefil Ladislav Zeman Vaclav |
| author_facet | Broz Pavel Rajdl Daniel Novak Jaroslav Hromadka Milan Racek Jaroslav Trefil Ladislav Zeman Vaclav |
| author_sort | Broz Pavel |
| collection | DOAJ |
| description | Background: The aim of this study was to examine highsensitivity troponin T and I (hsTnT and hsTnI) after a treadmill run under laboratory conditions and to find a possible connection with echocardiographic, laboratory and other assessed parameters. Methods: Nineteen trained men underwent a standardized 2-hour-long treadmill run. Concentrations of hsTnT and hsTnI were assessed before the run, 60, 120 and 180 minutes after the start and 24 hours after the run. Changes in troponins were tested using non-parametric analysis of variance (ANOVA). The multiple linear regression model was used to find the explanatory variables for hsTnT and hsTnI changes. Values of troponins were evaluated using the 0h/1h algorithm. Results: Changes in hsTnT and hsTnI levels were statistically significant (p<0.0001 and p < 0.0 001, respectively). In a multiple regression model (adjusted R2: 0.60, p = 0.005 for hsTnT and adjusted R2: 0.60, p= 0.005 for hsTnI), changes in both troponins can be explained by relative left wall thickness (LV), training volume, body temperature after the run and creatinine changes. According to the 0h/1h algorithm, none of the runners was evaluated as negative. Conclusions: Relative LV wall thickness, creatinine changes, training volume and body temperature after the run can predict changes in hsTnT and hsTnl levels. When medical attention is needed after physical exercise, hsTn levels should be tested only when clinical suspicion and the patient's history indicate a high probability of myocardial damage. |
| first_indexed | 2024-12-20T19:54:16Z |
| format | Article |
| id | doaj.art-d4a1a982a5f44cb0aad7a8cc475728a1 |
| institution | Directory Open Access Journal |
| issn | 1452-8258 1452-8266 |
| language | English |
| last_indexed | 2024-12-20T19:54:16Z |
| publishDate | 2018-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj.art-d4a1a982a5f44cb0aad7a8cc475728a12022-12-21T19:28:13ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662018-01-013733643721452-82581803364BHigh-sensitivity troponins after a standardized 2-hour treadmill runBroz Pavel0Rajdl Daniel1Novak Jaroslav2Hromadka Milan3Racek Jaroslav4Trefil Ladislav5Zeman Vaclav6University Hospital in Pilsen, Institute of Clinical Biochemistry and Haematology, Pilsen, Czech Republic + Charles University in Prague, Faculty of Medicine in Pilsen, Prague, Czech RepublicCharles University in Prague, Department of Sports Medicine, Prague, Czech RepublicCharles University in Prague, Department of Sports Medicine, Prague, Czech RepublicUniversity Hospital in Pilsen, Department of Cardiology, Pilsen, Czech RepublicUniversity Hospital in Pilsen, Institute of Clinical Biochemistry and Haematology, Pilsen, Czech Republic + Charles University in Prague, Faculty of Medicine in Pilsen, Prague, Czech RepublicUniversity Hospital in Pilsen, Institute of Clinical Biochemistry and Haematology, Pilsen, Czech RepublicCharles University in Prague, Department of Sports Medicine, Prague, Czech RepublicBackground: The aim of this study was to examine highsensitivity troponin T and I (hsTnT and hsTnI) after a treadmill run under laboratory conditions and to find a possible connection with echocardiographic, laboratory and other assessed parameters. Methods: Nineteen trained men underwent a standardized 2-hour-long treadmill run. Concentrations of hsTnT and hsTnI were assessed before the run, 60, 120 and 180 minutes after the start and 24 hours after the run. Changes in troponins were tested using non-parametric analysis of variance (ANOVA). The multiple linear regression model was used to find the explanatory variables for hsTnT and hsTnI changes. Values of troponins were evaluated using the 0h/1h algorithm. Results: Changes in hsTnT and hsTnI levels were statistically significant (p<0.0001 and p < 0.0 001, respectively). In a multiple regression model (adjusted R2: 0.60, p = 0.005 for hsTnT and adjusted R2: 0.60, p= 0.005 for hsTnI), changes in both troponins can be explained by relative left wall thickness (LV), training volume, body temperature after the run and creatinine changes. According to the 0h/1h algorithm, none of the runners was evaluated as negative. Conclusions: Relative LV wall thickness, creatinine changes, training volume and body temperature after the run can predict changes in hsTnT and hsTnl levels. When medical attention is needed after physical exercise, hsTn levels should be tested only when clinical suspicion and the patient's history indicate a high probability of myocardial damage.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2018/1452-82581803364B.pdfhigh-sensitivity troponinsrunningstandardized exerciseechocardiography |
| spellingShingle | Broz Pavel Rajdl Daniel Novak Jaroslav Hromadka Milan Racek Jaroslav Trefil Ladislav Zeman Vaclav High-sensitivity troponins after a standardized 2-hour treadmill run Journal of Medical Biochemistry high-sensitivity troponins running standardized exercise echocardiography |
| title | High-sensitivity troponins after a standardized 2-hour treadmill run |
| title_full | High-sensitivity troponins after a standardized 2-hour treadmill run |
| title_fullStr | High-sensitivity troponins after a standardized 2-hour treadmill run |
| title_full_unstemmed | High-sensitivity troponins after a standardized 2-hour treadmill run |
| title_short | High-sensitivity troponins after a standardized 2-hour treadmill run |
| title_sort | high sensitivity troponins after a standardized 2 hour treadmill run |
| topic | high-sensitivity troponins running standardized exercise echocardiography |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2018/1452-82581803364B.pdf |
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