Synthesis and chemical behaviour of 17α-butyl-3β,17β-dihydroxy-16-oximino-5-androstene
Starting from 3 -hydroxy-16-oximino-5-androsten-17-one (1), the recently synthesized 16-oximino-17 -hydroxy-17 -butyl derivative 2 gave by the Beckmann fragmentation reactionwith titanium(III) chloride or p-toluenesulphonyl chloride the corresponding D-seco derivative 3. However, using a...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Serbian Chemical Society
2001-01-01
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| Series: | Journal of the Serbian Chemical Society |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0352-5139/2001/0352-51390101023S.pdf |
| Summary: | Starting from 3 -hydroxy-16-oximino-5-androsten-17-one (1), the recently
synthesized 16-oximino-17 -hydroxy-17 -butyl derivative 2 gave by the
Beckmann fragmentation reactionwith titanium(III) chloride or
p-toluenesulphonyl chloride the corresponding D-seco derivative 3. However,
using acetic anhydride, in addition to the 3 -acetoxy D-seco derivative 4,
the 17-aza D-homo derivative 5 was obtained. The structure of compound 5 was
proposed on the basis of NMR-spectroscopy. |
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| ISSN: | 0352-5139 1820-7421 |