Clinical and Molecular Aspects of Iron Metabolism in Failing Myocytes
Heart failure (HF) is a common disease that causes significant limitations on the organism’s capacity and, in extreme cases, leads to death. Clinically, iron deficiency (ID) plays an essential role in heart failure by deteriorating the patient’s condition and is a prognostic marker indicating poor c...
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| Format: | Article |
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MDPI AG
2022-08-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/12/8/1203 |
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| author | Bogna Kozłowska Barbara Sochanowicz Leszek Kraj Małgorzata Palusińska Piotr Kołsut Łukasz Szymański Sławomir Lewicki Marcin Kruszewski Marta Załęska-Kocięcka Przemysław Leszek |
| author_facet | Bogna Kozłowska Barbara Sochanowicz Leszek Kraj Małgorzata Palusińska Piotr Kołsut Łukasz Szymański Sławomir Lewicki Marcin Kruszewski Marta Załęska-Kocięcka Przemysław Leszek |
| author_sort | Bogna Kozłowska |
| collection | DOAJ |
| description | Heart failure (HF) is a common disease that causes significant limitations on the organism’s capacity and, in extreme cases, leads to death. Clinically, iron deficiency (ID) plays an essential role in heart failure by deteriorating the patient’s condition and is a prognostic marker indicating poor clinical outcomes. Therefore, in HF patients, supplementation of iron is recommended. However, iron treatment may cause adverse effects by increasing iron-related apoptosis and the production of oxygen radicals, which may cause additional heart damage. Furthermore, many knowledge gaps exist regarding the complex interplay between iron deficiency and heart failure. Here, we describe the current, comprehensive knowledge about the role of the proteins involved in iron metabolism. We will focus on the molecular and clinical aspects of iron deficiency in HF. We believe that summarizing the new advances in the translational and clinical research regarding iron deficiency in heart failure should broaden clinicians’ awareness of this comorbidity. |
| first_indexed | 2024-03-09T13:06:06Z |
| format | Article |
| id | doaj.art-d4a3b93624ca4ddf94cf20d18104282e |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T13:06:06Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-d4a3b93624ca4ddf94cf20d18104282e2023-11-30T21:49:25ZengMDPI AGLife2075-17292022-08-01128120310.3390/life12081203Clinical and Molecular Aspects of Iron Metabolism in Failing MyocytesBogna Kozłowska0Barbara Sochanowicz1Leszek Kraj2Małgorzata Palusińska3Piotr Kołsut4Łukasz Szymański5Sławomir Lewicki6Marcin Kruszewski7Marta Załęska-Kocięcka8Przemysław Leszek9Department of Heart Failure and Transplantology, The Cardinal Stefan Wyszyński National Institute of Cardiology, Alpejska 42, 04-628 Warsaw, PolandCenter of Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, PolandDepartment of Oncology, Medical University of Warsaw, 1A Banacha Str., 02-097 Warsaw, PolandDepartment of Molecular Biology, Institute of Genetics and Animal Biotechnology, Polish Academy of Science, Postępu 36A, 05-552 Magdalenka, PolandDepartment of Cardiac Surgery and Transplantology, The Cardinal Stefan Wyszyński National Institute of Cardiology, Alpejska 42, 04-628 Warsaw, PolandDepartment of Molecular Biology, Institute of Genetics and Animal Biotechnology, Polish Academy of Science, Postępu 36A, 05-552 Magdalenka, PolandDepartment of Molecular Biology, Institute of Genetics and Animal Biotechnology, Polish Academy of Science, Postępu 36A, 05-552 Magdalenka, PolandCenter of Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, PolandDepartment of Heart Failure and Transplantology, The Cardinal Stefan Wyszyński National Institute of Cardiology, Alpejska 42, 04-628 Warsaw, PolandDepartment of Heart Failure and Transplantology, The Cardinal Stefan Wyszyński National Institute of Cardiology, Alpejska 42, 04-628 Warsaw, PolandHeart failure (HF) is a common disease that causes significant limitations on the organism’s capacity and, in extreme cases, leads to death. Clinically, iron deficiency (ID) plays an essential role in heart failure by deteriorating the patient’s condition and is a prognostic marker indicating poor clinical outcomes. Therefore, in HF patients, supplementation of iron is recommended. However, iron treatment may cause adverse effects by increasing iron-related apoptosis and the production of oxygen radicals, which may cause additional heart damage. Furthermore, many knowledge gaps exist regarding the complex interplay between iron deficiency and heart failure. Here, we describe the current, comprehensive knowledge about the role of the proteins involved in iron metabolism. We will focus on the molecular and clinical aspects of iron deficiency in HF. We believe that summarizing the new advances in the translational and clinical research regarding iron deficiency in heart failure should broaden clinicians’ awareness of this comorbidity.https://www.mdpi.com/2075-1729/12/8/1203heart failuremyocardial iron metabolismoxidative stressmyocardial gathering proteins expressionhuman model |
| spellingShingle | Bogna Kozłowska Barbara Sochanowicz Leszek Kraj Małgorzata Palusińska Piotr Kołsut Łukasz Szymański Sławomir Lewicki Marcin Kruszewski Marta Załęska-Kocięcka Przemysław Leszek Clinical and Molecular Aspects of Iron Metabolism in Failing Myocytes Life heart failure myocardial iron metabolism oxidative stress myocardial gathering proteins expression human model |
| title | Clinical and Molecular Aspects of Iron Metabolism in Failing Myocytes |
| title_full | Clinical and Molecular Aspects of Iron Metabolism in Failing Myocytes |
| title_fullStr | Clinical and Molecular Aspects of Iron Metabolism in Failing Myocytes |
| title_full_unstemmed | Clinical and Molecular Aspects of Iron Metabolism in Failing Myocytes |
| title_short | Clinical and Molecular Aspects of Iron Metabolism in Failing Myocytes |
| title_sort | clinical and molecular aspects of iron metabolism in failing myocytes |
| topic | heart failure myocardial iron metabolism oxidative stress myocardial gathering proteins expression human model |
| url | https://www.mdpi.com/2075-1729/12/8/1203 |
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