Eugenol Attenuates Cerebral Ischemia-Reperfusion Injury by Enhancing Autophagy via AMPK-mTOR-P70S6K Pathway

Eugenol Attenuates Cerebral Ischemia-Reperfusion Injury by Enhancing Autophagy via AMPK-mTOR-P70S6K Pathway

Eugenol, as an active compound isolated from Acorus gramineus, has been shown to protect against cerebral ischemia-reperfusion (I/R) injury. Nonetheless, the detailed neuroprotective mechanisms of eugenol in cerebral I/R injury have not been elaborated. In the present study, cerebral I/R injury mode...

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Bibliographic Details
Main Authors: Xiaowei Sun, Dongyan Wang, Tingting Zhang, Xuejian Lu, Fangfang Duan, Lili Ju, Xiaotong Zhuang, Xicheng Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Pharmacology
Subjects:
eugenol
cerebral I/R injury
autophagy
HT 22
AMPK/mTOR/P70S6K pathway
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00084/full

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