Serological screening for celiac disease in adults in Japan: Shimane CoHRE study
Abstract Background and Aim Celiac disease (CD) is a chronic autoimmune enteropathy triggered by ingested gluten in genetically predisposed individuals. Although common in Europe and the United States, cases of CD are rarely encountered in East Asia, including Japan, and its prevalence remains to be...
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Wiley
2020-08-01
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| Series: | JGH Open |
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| Online Access: | https://doi.org/10.1002/jgh3.12334 |
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| author | Mai Fukunaga Norihisa Ishimura Takafumi Abe Miwako Takeda Minoru Isomura Yoshikazu Kinoshita Shunji Ishihara |
| author_facet | Mai Fukunaga Norihisa Ishimura Takafumi Abe Miwako Takeda Minoru Isomura Yoshikazu Kinoshita Shunji Ishihara |
| author_sort | Mai Fukunaga |
| collection | DOAJ |
| description | Abstract Background and Aim Celiac disease (CD) is a chronic autoimmune enteropathy triggered by ingested gluten in genetically predisposed individuals. Although common in Europe and the United States, cases of CD are rarely encountered in East Asia, including Japan, and its prevalence remains to be fully evaluated in a large‐scale study. We previously investigated the presence of CD in adults in Japan, which revealed a low prevalence of 1 (0.05%) of 2008 nonclinical subjects, while 1 (2.1%) of 47 symptomatic patients was diagnosed based on serology and duodenal histopathology results. To confirm those results, we conducted an additional retrospective serological screening study of adults in Japan. Methods Serum samples were collected from 2055 adults who underwent a health examination in four local areas of Shimane prefecture in Japan from July 2008 to August 2013. As a screening test for CD, the antitissue transglutaminase IgA antibody (TTG) titer was determined in all subjects, and a value greater than 10 U/mL was considered to be evidence of CD. Results Of the 2055 subjects, 4 (0.19%) showed a high concentration of TTG. Although two of the four who were seropositive had died at the time of this retrospective study, none reported prominent digestive symptoms such as diarrhea or weight loss in a follow‐up survey. Conclusions Among a general population in Japan, a positive rate of serological tests for CD was noted in 0.19%, indicating quite a low presence, consistent with our previous results. |
| first_indexed | 2024-12-22T06:39:44Z |
| format | Article |
| id | doaj.art-d4a55688a455423084a77aa3c4c7f404 |
| institution | Directory Open Access Journal |
| issn | 2397-9070 |
| language | English |
| last_indexed | 2024-12-22T06:39:44Z |
| publishDate | 2020-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | JGH Open |
| spelling | doaj.art-d4a55688a455423084a77aa3c4c7f4042022-12-21T18:35:28ZengWileyJGH Open2397-90702020-08-014455856010.1002/jgh3.12334Serological screening for celiac disease in adults in Japan: Shimane CoHRE studyMai Fukunaga0Norihisa Ishimura1Takafumi Abe2Miwako Takeda3Minoru Isomura4Yoshikazu Kinoshita5Shunji Ishihara6Second Department of Internal Medicine Shimane University Faculty of Medicine Izumo JapanSecond Department of Internal Medicine Shimane University Faculty of Medicine Izumo JapanCenter for Community‐Based Healthcare Research and Education (CoHRE), Organization for Research and Academic Information Shimane University Izumo JapanCenter for Community‐Based Healthcare Research and Education (CoHRE), Organization for Research and Academic Information Shimane University Izumo JapanCenter for Community‐Based Healthcare Research and Education (CoHRE), Organization for Research and Academic Information Shimane University Izumo JapanSecond Department of Internal Medicine Shimane University Faculty of Medicine Izumo JapanSecond Department of Internal Medicine Shimane University Faculty of Medicine Izumo JapanAbstract Background and Aim Celiac disease (CD) is a chronic autoimmune enteropathy triggered by ingested gluten in genetically predisposed individuals. Although common in Europe and the United States, cases of CD are rarely encountered in East Asia, including Japan, and its prevalence remains to be fully evaluated in a large‐scale study. We previously investigated the presence of CD in adults in Japan, which revealed a low prevalence of 1 (0.05%) of 2008 nonclinical subjects, while 1 (2.1%) of 47 symptomatic patients was diagnosed based on serology and duodenal histopathology results. To confirm those results, we conducted an additional retrospective serological screening study of adults in Japan. Methods Serum samples were collected from 2055 adults who underwent a health examination in four local areas of Shimane prefecture in Japan from July 2008 to August 2013. As a screening test for CD, the antitissue transglutaminase IgA antibody (TTG) titer was determined in all subjects, and a value greater than 10 U/mL was considered to be evidence of CD. Results Of the 2055 subjects, 4 (0.19%) showed a high concentration of TTG. Although two of the four who were seropositive had died at the time of this retrospective study, none reported prominent digestive symptoms such as diarrhea or weight loss in a follow‐up survey. Conclusions Among a general population in Japan, a positive rate of serological tests for CD was noted in 0.19%, indicating quite a low presence, consistent with our previous results.https://doi.org/10.1002/jgh3.12334antitissue transglutaminase IgAceliac diseaseHuman leukocyte antigenprevalence |
| spellingShingle | Mai Fukunaga Norihisa Ishimura Takafumi Abe Miwako Takeda Minoru Isomura Yoshikazu Kinoshita Shunji Ishihara Serological screening for celiac disease in adults in Japan: Shimane CoHRE study JGH Open antitissue transglutaminase IgA celiac disease Human leukocyte antigen prevalence |
| title | Serological screening for celiac disease in adults in Japan: Shimane CoHRE study |
| title_full | Serological screening for celiac disease in adults in Japan: Shimane CoHRE study |
| title_fullStr | Serological screening for celiac disease in adults in Japan: Shimane CoHRE study |
| title_full_unstemmed | Serological screening for celiac disease in adults in Japan: Shimane CoHRE study |
| title_short | Serological screening for celiac disease in adults in Japan: Shimane CoHRE study |
| title_sort | serological screening for celiac disease in adults in japan shimane cohre study |
| topic | antitissue transglutaminase IgA celiac disease Human leukocyte antigen prevalence |
| url | https://doi.org/10.1002/jgh3.12334 |
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