Limited Clinical Value of Anti-Retinal Antibody Titers and Numbers in Autoimmune Retinopathy
Ploysai Rujkorakarn,1– 3 Michael J Margolis,1,2 Diana Morvey,1,2 Yujia Zhou,1,2 C Stephen Foster1,2,4 1Massachusetts Eye Research and Surgery Institution, Waltham, MA, USA; 2The Ocular Immunology and Uveitis Foundation, Waltham, MA, USA; 3Suddhavej Hospital Department of Ophthalmology, Mahasarakham...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-03-01
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| Series: | Clinical Ophthalmology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/limited-clinical-value-of-anti-retinal-antibody-titers-and-numbers-in--peer-reviewed-fulltext-article-OPTH |
| _version_ | 1811158631725400064 |
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| author | Rujkorakarn P Margolis MJ Morvey D Zhou Y Foster CS |
| author_facet | Rujkorakarn P Margolis MJ Morvey D Zhou Y Foster CS |
| author_sort | Rujkorakarn P |
| collection | DOAJ |
| description | Ploysai Rujkorakarn,1– 3 Michael J Margolis,1,2 Diana Morvey,1,2 Yujia Zhou,1,2 C Stephen Foster1,2,4 1Massachusetts Eye Research and Surgery Institution, Waltham, MA, USA; 2The Ocular Immunology and Uveitis Foundation, Waltham, MA, USA; 3Suddhavej Hospital Department of Ophthalmology, Mahasarakham University, Maha Sarakham, Thailand; 4Department of Ophthalmology, Harvard Medical School, Cambridge, MA, USACorrespondence: C Stephen Foster, Massachusetts Eye Research and Surgery Institution, 1440 Main St. #201, Waltham, MA, 02451, USA, Tel +1 781 891-6377, Fax +1 781 647-1430, Email sfoster@mersi.comPurpose: To assess the possible correlation of anti-retinal antibody titers and number of anti-retinal antibodies with outcome measurements including visual acuity, subjective vision loss, visual field, and electroretinography in patients with autoimmune retinopathy.Design: Single-center, retrospective cross-sectional study.Patients and Methods: Patients with autoimmune retinopathy who underwent anti-retinal antibody testing at least twice during their follow-up were enrolled. Anti-retinal antibody titers and numbers were grouped as improved, stable, or worsened. Outcomes included Snellen visual acuity, patient-reported vision loss, Humphrey visual field mean deviations, and electroretinography parameters.Results: Thirty-one eyes among 16 patients with autoimmune retinopathy were included. Between-group analyses of visual acuity, subjective vision loss, visual field, and electroretinography outcomes did not reveal any significant differences by anti-retinal antibody titer or number group at a 95% confidence interval.Conclusion: Changes in anti-retinal antibody titers or numbers were not associated with any vision outcome. Repeated anti-retinal antibody testing may be unnecessary after diagnosis of autoimmune retinopathy and detection of an anti-retinal antibody.Keywords: autoimmune retinopathy, anti-retinal antibody, visual field, electroretinography, outcome measurements |
| first_indexed | 2024-04-10T05:26:14Z |
| format | Article |
| id | doaj.art-d4a5bed25693410797d6752da54bcbb4 |
| institution | Directory Open Access Journal |
| issn | 1177-5483 |
| language | English |
| last_indexed | 2024-04-10T05:26:14Z |
| publishDate | 2023-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Ophthalmology |
| spelling | doaj.art-d4a5bed25693410797d6752da54bcbb42023-03-07T18:15:45ZengDove Medical PressClinical Ophthalmology1177-54832023-03-01Volume 1774975582072Limited Clinical Value of Anti-Retinal Antibody Titers and Numbers in Autoimmune RetinopathyRujkorakarn PMargolis MJMorvey DZhou YFoster CSPloysai Rujkorakarn,1– 3 Michael J Margolis,1,2 Diana Morvey,1,2 Yujia Zhou,1,2 C Stephen Foster1,2,4 1Massachusetts Eye Research and Surgery Institution, Waltham, MA, USA; 2The Ocular Immunology and Uveitis Foundation, Waltham, MA, USA; 3Suddhavej Hospital Department of Ophthalmology, Mahasarakham University, Maha Sarakham, Thailand; 4Department of Ophthalmology, Harvard Medical School, Cambridge, MA, USACorrespondence: C Stephen Foster, Massachusetts Eye Research and Surgery Institution, 1440 Main St. #201, Waltham, MA, 02451, USA, Tel +1 781 891-6377, Fax +1 781 647-1430, Email sfoster@mersi.comPurpose: To assess the possible correlation of anti-retinal antibody titers and number of anti-retinal antibodies with outcome measurements including visual acuity, subjective vision loss, visual field, and electroretinography in patients with autoimmune retinopathy.Design: Single-center, retrospective cross-sectional study.Patients and Methods: Patients with autoimmune retinopathy who underwent anti-retinal antibody testing at least twice during their follow-up were enrolled. Anti-retinal antibody titers and numbers were grouped as improved, stable, or worsened. Outcomes included Snellen visual acuity, patient-reported vision loss, Humphrey visual field mean deviations, and electroretinography parameters.Results: Thirty-one eyes among 16 patients with autoimmune retinopathy were included. Between-group analyses of visual acuity, subjective vision loss, visual field, and electroretinography outcomes did not reveal any significant differences by anti-retinal antibody titer or number group at a 95% confidence interval.Conclusion: Changes in anti-retinal antibody titers or numbers were not associated with any vision outcome. Repeated anti-retinal antibody testing may be unnecessary after diagnosis of autoimmune retinopathy and detection of an anti-retinal antibody.Keywords: autoimmune retinopathy, anti-retinal antibody, visual field, electroretinography, outcome measurementshttps://www.dovepress.com/limited-clinical-value-of-anti-retinal-antibody-titers-and-numbers-in--peer-reviewed-fulltext-article-OPTHautoimmune retinopathyanti-retinal antibodyvisual fieldelectroretinographyoutcome measurements |
| spellingShingle | Rujkorakarn P Margolis MJ Morvey D Zhou Y Foster CS Limited Clinical Value of Anti-Retinal Antibody Titers and Numbers in Autoimmune Retinopathy Clinical Ophthalmology autoimmune retinopathy anti-retinal antibody visual field electroretinography outcome measurements |
| title | Limited Clinical Value of Anti-Retinal Antibody Titers and Numbers in Autoimmune Retinopathy |
| title_full | Limited Clinical Value of Anti-Retinal Antibody Titers and Numbers in Autoimmune Retinopathy |
| title_fullStr | Limited Clinical Value of Anti-Retinal Antibody Titers and Numbers in Autoimmune Retinopathy |
| title_full_unstemmed | Limited Clinical Value of Anti-Retinal Antibody Titers and Numbers in Autoimmune Retinopathy |
| title_short | Limited Clinical Value of Anti-Retinal Antibody Titers and Numbers in Autoimmune Retinopathy |
| title_sort | limited clinical value of anti retinal antibody titers and numbers in autoimmune retinopathy |
| topic | autoimmune retinopathy anti-retinal antibody visual field electroretinography outcome measurements |
| url | https://www.dovepress.com/limited-clinical-value-of-anti-retinal-antibody-titers-and-numbers-in--peer-reviewed-fulltext-article-OPTH |
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