The Effect of Metabolic Syndrome on the Outcome of Hepatitis B-Associated Hepatocellular Carcinoma Patients After Hepatectomy: A Multicenter Study
Background and AimsWith changes in dietary patterns and modern lifestyles, the prevalence of metabolic syndrome (MetS) in hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) patients is increasing. The purpose of our study is to explore the impact of MetS on the prognosis of HBV-associ...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-03-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.811084/full |
| _version_ | 1819294398340399104 |
|---|---|
| author | Junlong Dai Xinrui Zhu Junyi Shen Yu Zhang Fei Xie Yu Yu Kangyi Jiang Tianfu Wen Chuan Li |
| author_facet | Junlong Dai Xinrui Zhu Junyi Shen Yu Zhang Fei Xie Yu Yu Kangyi Jiang Tianfu Wen Chuan Li |
| author_sort | Junlong Dai |
| collection | DOAJ |
| description | Background and AimsWith changes in dietary patterns and modern lifestyles, the prevalence of metabolic syndrome (MetS) in hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) patients is increasing. The purpose of our study is to explore the impact of MetS on the prognosis of HBV-associated HCC patients following radical hepatectomy.MethodsData on consecutive HCC patients who underwent radical hepatectomy were prospectively obtained and retrospectively analyzed from seven medical centers in west areas of China. Propensity score matching (PSM) analysis was conducted to balance the heterogeneity between MetS-HBV-HCC group and HBV-HCC group. Surgical outcomes have been contrasted between the two groups.ResultsIn 984 patients, 179 (18.19%) were diagnosed with MetS. Patients in the MetS-HBV-HCC group had higher CCI score (8.7 [0.0, 12.2] vs. 0.0 [0.0, 8.7], p = 0.048) and a higher rate of severe complications (Clavien–Dindo ≥3, 7.82% vs. 4.10%, p = 0.035), to be more precise: postoperative liver failure, hydrothorax, and hyperglycemia. Patients in the MetS-HBV-HCC group tended to have worse 5-year overall survival (OS) rate (61.45% vs. 69.94%, p = 0.027) and recurrence-free survival (RFS) rate (62.57% vs. 53.66%, p = 0.030), consistent with the results of the competing risk models. Last, MetS was identified to be an independent unfavorable prognostic factor in the multivariate analysis.ConclusionThe involvement of MetS increased the risk of postoperative complications and worsens the overall survival and recurrence-free survival time, reminding us to be more prudent to face metabolic disorder among tumor patients. |
| first_indexed | 2024-12-24T04:25:41Z |
| format | Article |
| id | doaj.art-d4a616c5348e4ef9ae3dd3753757caaf |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-24T04:25:41Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-d4a616c5348e4ef9ae3dd3753757caaf2022-12-21T17:15:39ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-03-011210.3389/fonc.2022.811084811084The Effect of Metabolic Syndrome on the Outcome of Hepatitis B-Associated Hepatocellular Carcinoma Patients After Hepatectomy: A Multicenter StudyJunlong Dai0Xinrui Zhu1Junyi Shen2Yu Zhang3Fei Xie4Yu Yu5Kangyi Jiang6Tianfu Wen7Chuan Li8Liver Transplantation Center, Department of Liver Surgery, West China Hospital, Chengdu, ChinaLiver Transplantation Center, Department of Liver Surgery, West China Hospital, Chengdu, ChinaLiver Transplantation Center, Department of Liver Surgery, West China Hospital, Chengdu, ChinaOrgan Transplantation Center, Sichuan Academy of Medical Sciences (Sichuan Provincial People’s Hospital), Chinese Academy of Sciences, Chengdu, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, the First People’s Hospital of Neijiang City, Neijiang, ChinaDepartment of Hepatopancreatobiliary Surgery, the Second People’s Hospital of Yibin City, Yibin, ChinaDepartment of Hepatobiliary Surgery, People’s Hospital of Leshan, Southwest Medical University, Leshan, ChinaLiver Transplantation Center, Department of Liver Surgery, West China Hospital, Chengdu, ChinaLiver Transplantation Center, Department of Liver Surgery, West China Hospital, Chengdu, ChinaBackground and AimsWith changes in dietary patterns and modern lifestyles, the prevalence of metabolic syndrome (MetS) in hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) patients is increasing. The purpose of our study is to explore the impact of MetS on the prognosis of HBV-associated HCC patients following radical hepatectomy.MethodsData on consecutive HCC patients who underwent radical hepatectomy were prospectively obtained and retrospectively analyzed from seven medical centers in west areas of China. Propensity score matching (PSM) analysis was conducted to balance the heterogeneity between MetS-HBV-HCC group and HBV-HCC group. Surgical outcomes have been contrasted between the two groups.ResultsIn 984 patients, 179 (18.19%) were diagnosed with MetS. Patients in the MetS-HBV-HCC group had higher CCI score (8.7 [0.0, 12.2] vs. 0.0 [0.0, 8.7], p = 0.048) and a higher rate of severe complications (Clavien–Dindo ≥3, 7.82% vs. 4.10%, p = 0.035), to be more precise: postoperative liver failure, hydrothorax, and hyperglycemia. Patients in the MetS-HBV-HCC group tended to have worse 5-year overall survival (OS) rate (61.45% vs. 69.94%, p = 0.027) and recurrence-free survival (RFS) rate (62.57% vs. 53.66%, p = 0.030), consistent with the results of the competing risk models. Last, MetS was identified to be an independent unfavorable prognostic factor in the multivariate analysis.ConclusionThe involvement of MetS increased the risk of postoperative complications and worsens the overall survival and recurrence-free survival time, reminding us to be more prudent to face metabolic disorder among tumor patients.https://www.frontiersin.org/articles/10.3389/fonc.2022.811084/fullmetabolic syndromehepatocellular carcinomaHBV-associated HCChepatectomyprognosis |
| spellingShingle | Junlong Dai Xinrui Zhu Junyi Shen Yu Zhang Fei Xie Yu Yu Kangyi Jiang Tianfu Wen Chuan Li The Effect of Metabolic Syndrome on the Outcome of Hepatitis B-Associated Hepatocellular Carcinoma Patients After Hepatectomy: A Multicenter Study Frontiers in Oncology metabolic syndrome hepatocellular carcinoma HBV-associated HCC hepatectomy prognosis |
| title | The Effect of Metabolic Syndrome on the Outcome of Hepatitis B-Associated Hepatocellular Carcinoma Patients After Hepatectomy: A Multicenter Study |
| title_full | The Effect of Metabolic Syndrome on the Outcome of Hepatitis B-Associated Hepatocellular Carcinoma Patients After Hepatectomy: A Multicenter Study |
| title_fullStr | The Effect of Metabolic Syndrome on the Outcome of Hepatitis B-Associated Hepatocellular Carcinoma Patients After Hepatectomy: A Multicenter Study |
| title_full_unstemmed | The Effect of Metabolic Syndrome on the Outcome of Hepatitis B-Associated Hepatocellular Carcinoma Patients After Hepatectomy: A Multicenter Study |
| title_short | The Effect of Metabolic Syndrome on the Outcome of Hepatitis B-Associated Hepatocellular Carcinoma Patients After Hepatectomy: A Multicenter Study |
| title_sort | effect of metabolic syndrome on the outcome of hepatitis b associated hepatocellular carcinoma patients after hepatectomy a multicenter study |
| topic | metabolic syndrome hepatocellular carcinoma HBV-associated HCC hepatectomy prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.811084/full |
| work_keys_str_mv | AT junlongdai theeffectofmetabolicsyndromeontheoutcomeofhepatitisbassociatedhepatocellularcarcinomapatientsafterhepatectomyamulticenterstudy AT xinruizhu theeffectofmetabolicsyndromeontheoutcomeofhepatitisbassociatedhepatocellularcarcinomapatientsafterhepatectomyamulticenterstudy AT junyishen theeffectofmetabolicsyndromeontheoutcomeofhepatitisbassociatedhepatocellularcarcinomapatientsafterhepatectomyamulticenterstudy AT yuzhang theeffectofmetabolicsyndromeontheoutcomeofhepatitisbassociatedhepatocellularcarcinomapatientsafterhepatectomyamulticenterstudy AT feixie theeffectofmetabolicsyndromeontheoutcomeofhepatitisbassociatedhepatocellularcarcinomapatientsafterhepatectomyamulticenterstudy AT yuyu theeffectofmetabolicsyndromeontheoutcomeofhepatitisbassociatedhepatocellularcarcinomapatientsafterhepatectomyamulticenterstudy AT kangyijiang theeffectofmetabolicsyndromeontheoutcomeofhepatitisbassociatedhepatocellularcarcinomapatientsafterhepatectomyamulticenterstudy AT tianfuwen theeffectofmetabolicsyndromeontheoutcomeofhepatitisbassociatedhepatocellularcarcinomapatientsafterhepatectomyamulticenterstudy AT chuanli theeffectofmetabolicsyndromeontheoutcomeofhepatitisbassociatedhepatocellularcarcinomapatientsafterhepatectomyamulticenterstudy AT junlongdai effectofmetabolicsyndromeontheoutcomeofhepatitisbassociatedhepatocellularcarcinomapatientsafterhepatectomyamulticenterstudy AT xinruizhu effectofmetabolicsyndromeontheoutcomeofhepatitisbassociatedhepatocellularcarcinomapatientsafterhepatectomyamulticenterstudy AT junyishen effectofmetabolicsyndromeontheoutcomeofhepatitisbassociatedhepatocellularcarcinomapatientsafterhepatectomyamulticenterstudy AT yuzhang effectofmetabolicsyndromeontheoutcomeofhepatitisbassociatedhepatocellularcarcinomapatientsafterhepatectomyamulticenterstudy AT feixie effectofmetabolicsyndromeontheoutcomeofhepatitisbassociatedhepatocellularcarcinomapatientsafterhepatectomyamulticenterstudy AT yuyu effectofmetabolicsyndromeontheoutcomeofhepatitisbassociatedhepatocellularcarcinomapatientsafterhepatectomyamulticenterstudy AT kangyijiang effectofmetabolicsyndromeontheoutcomeofhepatitisbassociatedhepatocellularcarcinomapatientsafterhepatectomyamulticenterstudy AT tianfuwen effectofmetabolicsyndromeontheoutcomeofhepatitisbassociatedhepatocellularcarcinomapatientsafterhepatectomyamulticenterstudy AT chuanli effectofmetabolicsyndromeontheoutcomeofhepatitisbassociatedhepatocellularcarcinomapatientsafterhepatectomyamulticenterstudy |