Diagnostic evaluation of optical coherence tomography parameters in normal, preperimetric and perimetric glaucoma patients
AIM: To compare the diagnostic ability of glaucoma parameters measured by the optical coherence tomography (OCT) in normal, preperimetric glaucoma (PPG) and perimetric glaucoma (PG) patients. METHODS: This cross-sectional observational study includes 127 eyes of 127 subjects. Patients were divided i...
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| Format: | Article |
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Press of International Journal of Ophthalmology (IJO PRESS)
2022-11-01
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| Series: | International Journal of Ophthalmology |
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| Online Access: | http://ies.ijo.cn/en_publish/2022/11/20221108.pdf |
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| author | Aimy Mastura Zurairah Yusof Othmaliza Othman Seng Fai Tang Mohd Rohaizat Hassan Norshamsiah Md Din |
| author_facet | Aimy Mastura Zurairah Yusof Othmaliza Othman Seng Fai Tang Mohd Rohaizat Hassan Norshamsiah Md Din |
| author_sort | Aimy Mastura Zurairah Yusof |
| collection | DOAJ |
| description | AIM: To compare the diagnostic ability of glaucoma parameters measured by the optical coherence tomography (OCT) in normal, preperimetric glaucoma (PPG) and perimetric glaucoma (PG) patients. METHODS: This cross-sectional observational study includes 127 eyes of 127 subjects. Patients were divided into PPG (51 eyes), PG (46 eyes), and normal controls (30 eyes) based on clinical optic disc assessment and Humphrey visual field changes. The Heidelberg Spectralis OCT machine using Glaucoma Module Premium Edition software was used to measure the retinal nerve fiber layer (RNFL) and Bruch's membrane opening-minimum rim width (BMO-MRW) to assess the optic nerve head and ganglion cell layer (GCL) thickness in the macula. RESULTS: RNFL, MRW, and GCL thickness were all significantly thinner in PG compared to PPG and the normal group. The BMO-MRW parameters showed better specificity (>70%) at 90% specificity compared to both RNFL and GCL parameters to discriminate normal, PPG, and PG patients. All BMO-MRW parameters showed higher area under curves (AUC) compared to RNFL and GCL parameters with the highest AUC observed in the superotemporal sector of the BMO-MRW (AUC=0.819 and and 0.897 between normal and PPG and PG groups respectively). CONCLUSION: While the BMO-MRW best discriminates PPG and PG against normal eyes, GCL parameters poorly differentiate the three groups. |
| first_indexed | 2024-04-11T08:17:18Z |
| format | Article |
| id | doaj.art-d4a7b31770c24aa49a406c3dfa6776e7 |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-04-11T08:17:18Z |
| publishDate | 2022-11-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-d4a7b31770c24aa49a406c3dfa6776e72022-12-22T04:35:04ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982022-11-0115111782179010.18240/ijo.2022.11.0820221108Diagnostic evaluation of optical coherence tomography parameters in normal, preperimetric and perimetric glaucoma patientsAimy Mastura Zurairah Yusof0Othmaliza Othman1Seng Fai Tang2Mohd Rohaizat Hassan3Norshamsiah Md Din4Norshamsiah Md Din. Department of Ophthalmology, UKM Medical Center, Jalan Yaacob Latif, Cheras 56000, Kuala Lumpur, Malaysia. shamsiahdr@hotmail.comDepartment of Ophthalmology, UKM Medical Center, Jalan Yaacob Latif, Cheras 56000, Kuala Lumpur, MalaysiaDepartment of Ophthalmology, UKM Medical Center, Jalan Yaacob Latif, Cheras 56000, Kuala Lumpur, MalaysiaDepartment of Community Health, UKM Medical Center, Jalan Yaacob Latif, Cheras 56000, Kuala Lumpur, MalaysiaDepartment of Ophthalmology, UKM Medical Center, Jalan Yaacob Latif, Cheras 56000, Kuala Lumpur, MalaysiaAIM: To compare the diagnostic ability of glaucoma parameters measured by the optical coherence tomography (OCT) in normal, preperimetric glaucoma (PPG) and perimetric glaucoma (PG) patients. METHODS: This cross-sectional observational study includes 127 eyes of 127 subjects. Patients were divided into PPG (51 eyes), PG (46 eyes), and normal controls (30 eyes) based on clinical optic disc assessment and Humphrey visual field changes. The Heidelberg Spectralis OCT machine using Glaucoma Module Premium Edition software was used to measure the retinal nerve fiber layer (RNFL) and Bruch's membrane opening-minimum rim width (BMO-MRW) to assess the optic nerve head and ganglion cell layer (GCL) thickness in the macula. RESULTS: RNFL, MRW, and GCL thickness were all significantly thinner in PG compared to PPG and the normal group. The BMO-MRW parameters showed better specificity (>70%) at 90% specificity compared to both RNFL and GCL parameters to discriminate normal, PPG, and PG patients. All BMO-MRW parameters showed higher area under curves (AUC) compared to RNFL and GCL parameters with the highest AUC observed in the superotemporal sector of the BMO-MRW (AUC=0.819 and and 0.897 between normal and PPG and PG groups respectively). CONCLUSION: While the BMO-MRW best discriminates PPG and PG against normal eyes, GCL parameters poorly differentiate the three groups.http://ies.ijo.cn/en_publish/2022/11/20221108.pdfglaucomapreperimetricganglion cell layerbruch's membrane openingminimum rim widthretinal nerve fibre layer |
| spellingShingle | Aimy Mastura Zurairah Yusof Othmaliza Othman Seng Fai Tang Mohd Rohaizat Hassan Norshamsiah Md Din Diagnostic evaluation of optical coherence tomography parameters in normal, preperimetric and perimetric glaucoma patients International Journal of Ophthalmology glaucoma preperimetric ganglion cell layer bruch's membrane opening minimum rim width retinal nerve fibre layer |
| title | Diagnostic evaluation of optical coherence tomography parameters in normal, preperimetric and perimetric glaucoma patients |
| title_full | Diagnostic evaluation of optical coherence tomography parameters in normal, preperimetric and perimetric glaucoma patients |
| title_fullStr | Diagnostic evaluation of optical coherence tomography parameters in normal, preperimetric and perimetric glaucoma patients |
| title_full_unstemmed | Diagnostic evaluation of optical coherence tomography parameters in normal, preperimetric and perimetric glaucoma patients |
| title_short | Diagnostic evaluation of optical coherence tomography parameters in normal, preperimetric and perimetric glaucoma patients |
| title_sort | diagnostic evaluation of optical coherence tomography parameters in normal preperimetric and perimetric glaucoma patients |
| topic | glaucoma preperimetric ganglion cell layer bruch's membrane opening minimum rim width retinal nerve fibre layer |
| url | http://ies.ijo.cn/en_publish/2022/11/20221108.pdf |
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