Long-Term Tailor-Made Exercise Intervention Reduces the Risk of Developing Cardiovascular Diseases and All-Cause Mortality in Patients with Diabetic Kidney Disease
This study aimed to determine the effect of long-term exercise on the risk of developing cardiovascular diseases (CVD) and all-cause mortality in patients with diabetic kidney disease (DKD). A single-center, prospective intervention study using propensity score matching was performed over 24 months....
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/2/691 |
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| author | Hajime Tamiya Yuma Tamura Yasuko Nagashima Tomoki Tsurumi Masato Terashima Kaori Ochiai Kyosuke Ehara Tomoki Furuya Nobuyuki Banba Yuki Nakatani Megumi Hoshiai Asuka Ueno Takashi Tomoe Atsuhiko Kawabe Takushi Sugiyama Shinya Kawamoto Takanori Yasu |
| author_facet | Hajime Tamiya Yuma Tamura Yasuko Nagashima Tomoki Tsurumi Masato Terashima Kaori Ochiai Kyosuke Ehara Tomoki Furuya Nobuyuki Banba Yuki Nakatani Megumi Hoshiai Asuka Ueno Takashi Tomoe Atsuhiko Kawabe Takushi Sugiyama Shinya Kawamoto Takanori Yasu |
| author_sort | Hajime Tamiya |
| collection | DOAJ |
| description | This study aimed to determine the effect of long-term exercise on the risk of developing cardiovascular diseases (CVD) and all-cause mortality in patients with diabetic kidney disease (DKD). A single-center, prospective intervention study using propensity score matching was performed over 24 months. The intervention group (<i>n</i> = 67) received six months of individual exercise instruction from a physical therapist, who performed aerobic and muscle-strengthening exercises under unsupervised conditions. New events were defined as the composite endpoint of stroke or CVD requiring hospitalization, initiation of hemodialysis or peritoneal dialysis, or all-cause mortality. The cumulative survival rate without new events at 24 months was significantly higher in the intervention group (0.881, <i>p</i> = 0.016) than in the control group (<i>n</i> = 67, 0.715). Two-way analysis of variance revealed a significant effect of the group factor on high density lipoprotein-cholesterol (HDL-C) which was higher in the intervention group than in the control group (<i>p</i> = 0.004); eGFRcr showed a significant effect of the time factor, which was lower at 24 months than before intervention (<i>p</i> = 0.043). No interactions were observed for all items. In conclusion, aerobic exercises combined with upper and lower limb muscle strengthening for six months reduce the risk of developing CVD and all-cause mortality in patients with DKD. |
| first_indexed | 2024-03-09T12:10:00Z |
| format | Article |
| id | doaj.art-d4aa4e57d0d64b6396ab9066ebc6085e |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T12:10:00Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-d4aa4e57d0d64b6396ab9066ebc6085e2023-11-30T22:53:32ZengMDPI AGJournal of Clinical Medicine2077-03832023-01-0112269110.3390/jcm12020691Long-Term Tailor-Made Exercise Intervention Reduces the Risk of Developing Cardiovascular Diseases and All-Cause Mortality in Patients with Diabetic Kidney DiseaseHajime Tamiya0Yuma Tamura1Yasuko Nagashima2Tomoki Tsurumi3Masato Terashima4Kaori Ochiai5Kyosuke Ehara6Tomoki Furuya7Nobuyuki Banba8Yuki Nakatani9Megumi Hoshiai10Asuka Ueno11Takashi Tomoe12Atsuhiko Kawabe13Takushi Sugiyama14Shinya Kawamoto15Takanori Yasu16Department of Physical Therapy, Niigata University of Health and Welfare, Niigata 950-3198, JapanDepartment of Rehabilitation, Dokkyo Medical University Nikko Medical Center, Nikko 321-2593, JapanDepartment of Nursing, Dokkyo Medical University Nikko Medical Center, Nikko 321-2593, JapanDepartment of Rehabilitation, Dokkyo Medical University Nikko Medical Center, Nikko 321-2593, JapanDepartment of Rehabilitation, Dokkyo Medical University Nikko Medical Center, Nikko 321-2593, JapanDepartment of Rehabilitation, Dokkyo Medical University Nikko Medical Center, Nikko 321-2593, JapanDepartment of Rehabilitation, Dokkyo Medical University Nikko Medical Center, Nikko 321-2593, JapanSocial Participation and Community Health Research Team, Tokyo Metropolitan Institute of Gerontology, Itabashi 173-0015, JapanDepartment of Diabetes and Endocrinology, Dokkyo Medical University Nikko Medical Center, Nikko 321-2593, JapanDepartment of Diabetes and Endocrinology, Dokkyo Medical University Nikko Medical Center, Nikko 321-2593, JapanDepartment of Cardiovascular Medicine and Nephrology, Dokkyo Medical University Nikko Medical Center, 632 Takatoku, Nikko 321-2593, JapanDepartment of Cardiovascular Medicine and Nephrology, Dokkyo Medical University Nikko Medical Center, 632 Takatoku, Nikko 321-2593, JapanDepartment of Cardiovascular Medicine and Nephrology, Dokkyo Medical University Nikko Medical Center, 632 Takatoku, Nikko 321-2593, JapanDepartment of Cardiovascular Medicine and Nephrology, Dokkyo Medical University Nikko Medical Center, 632 Takatoku, Nikko 321-2593, JapanDepartment of Cardiovascular Medicine and Nephrology, Dokkyo Medical University Nikko Medical Center, 632 Takatoku, Nikko 321-2593, JapanDepartment of Cardiovascular Medicine and Nephrology, Dokkyo Medical University Nikko Medical Center, 632 Takatoku, Nikko 321-2593, JapanDepartment of Cardiovascular Medicine and Nephrology, Dokkyo Medical University Nikko Medical Center, 632 Takatoku, Nikko 321-2593, JapanThis study aimed to determine the effect of long-term exercise on the risk of developing cardiovascular diseases (CVD) and all-cause mortality in patients with diabetic kidney disease (DKD). A single-center, prospective intervention study using propensity score matching was performed over 24 months. The intervention group (<i>n</i> = 67) received six months of individual exercise instruction from a physical therapist, who performed aerobic and muscle-strengthening exercises under unsupervised conditions. New events were defined as the composite endpoint of stroke or CVD requiring hospitalization, initiation of hemodialysis or peritoneal dialysis, or all-cause mortality. The cumulative survival rate without new events at 24 months was significantly higher in the intervention group (0.881, <i>p</i> = 0.016) than in the control group (<i>n</i> = 67, 0.715). Two-way analysis of variance revealed a significant effect of the group factor on high density lipoprotein-cholesterol (HDL-C) which was higher in the intervention group than in the control group (<i>p</i> = 0.004); eGFRcr showed a significant effect of the time factor, which was lower at 24 months than before intervention (<i>p</i> = 0.043). No interactions were observed for all items. In conclusion, aerobic exercises combined with upper and lower limb muscle strengthening for six months reduce the risk of developing CVD and all-cause mortality in patients with DKD.https://www.mdpi.com/2077-0383/12/2/691cardiovascular eventsdiabetes mellitusdiabetic kidney diseaseexercisephysical therapist |
| spellingShingle | Hajime Tamiya Yuma Tamura Yasuko Nagashima Tomoki Tsurumi Masato Terashima Kaori Ochiai Kyosuke Ehara Tomoki Furuya Nobuyuki Banba Yuki Nakatani Megumi Hoshiai Asuka Ueno Takashi Tomoe Atsuhiko Kawabe Takushi Sugiyama Shinya Kawamoto Takanori Yasu Long-Term Tailor-Made Exercise Intervention Reduces the Risk of Developing Cardiovascular Diseases and All-Cause Mortality in Patients with Diabetic Kidney Disease Journal of Clinical Medicine cardiovascular events diabetes mellitus diabetic kidney disease exercise physical therapist |
| title | Long-Term Tailor-Made Exercise Intervention Reduces the Risk of Developing Cardiovascular Diseases and All-Cause Mortality in Patients with Diabetic Kidney Disease |
| title_full | Long-Term Tailor-Made Exercise Intervention Reduces the Risk of Developing Cardiovascular Diseases and All-Cause Mortality in Patients with Diabetic Kidney Disease |
| title_fullStr | Long-Term Tailor-Made Exercise Intervention Reduces the Risk of Developing Cardiovascular Diseases and All-Cause Mortality in Patients with Diabetic Kidney Disease |
| title_full_unstemmed | Long-Term Tailor-Made Exercise Intervention Reduces the Risk of Developing Cardiovascular Diseases and All-Cause Mortality in Patients with Diabetic Kidney Disease |
| title_short | Long-Term Tailor-Made Exercise Intervention Reduces the Risk of Developing Cardiovascular Diseases and All-Cause Mortality in Patients with Diabetic Kidney Disease |
| title_sort | long term tailor made exercise intervention reduces the risk of developing cardiovascular diseases and all cause mortality in patients with diabetic kidney disease |
| topic | cardiovascular events diabetes mellitus diabetic kidney disease exercise physical therapist |
| url | https://www.mdpi.com/2077-0383/12/2/691 |
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