TOETVA parathyroid autofluorescence detection: hANDY-i endoscopy attachment
BackgroundTreatment options for thyroid pathologies have expanded to include scarless and remote access methods such as the transoral endoscopic thyroidectomy vestibular approach (TOETVA). Currently, no standardized methods exist for locating parathyroid glands (PGs) in patients undergoing TOETVA, w...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1233956/full |
| _version_ | 1827860854536667136 |
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| author | Stefanie Seo Khalid Mohamed Ali Samantha A. Wolfe Nimesh V. Nagururu Andy S. Ding Dipan Desai R. Alex Harbison Yoseph Kim Bo Ning Richard Jaepyeong Cha Richard Jaepyeong Cha Richard Jaepyeong Cha Jonathon O. Russell |
| author_facet | Stefanie Seo Khalid Mohamed Ali Samantha A. Wolfe Nimesh V. Nagururu Andy S. Ding Dipan Desai R. Alex Harbison Yoseph Kim Bo Ning Richard Jaepyeong Cha Richard Jaepyeong Cha Richard Jaepyeong Cha Jonathon O. Russell |
| author_sort | Stefanie Seo |
| collection | DOAJ |
| description | BackgroundTreatment options for thyroid pathologies have expanded to include scarless and remote access methods such as the transoral endoscopic thyroidectomy vestibular approach (TOETVA). Currently, no standardized methods exist for locating parathyroid glands (PGs) in patients undergoing TOETVA, which can lead to parathyroid injury and subsequent hypocalcemia. This early feasibility study describes and evaluates the hANDY-i endoscopic attachment for detecting PGs in transoral thyroidectomy.MethodsWe used a prototype parathyroid autofluorescence imager (hANDY-i) that was mounted to a 10-mm 0-degree endoscope. The device delivers a split screen view of Red-green-blue (RGB) and near-infrared autofluorescence (NIRAF) which allows for simultaneous anatomical localization and fluorescence visualization of PGs during endoscopic thyroid dissection.ResultsOne cadaveric case and two patient cases were included in this study. The endoscopic hANDY-i imaging system successfully visualized PGs during all procedures.ConclusionThe ability to leverage parathyroid autofluorescence during TOETVA may lead to improved PG localization and preservation. Further human studies are needed to assess its effect on postoperative hypocalcemia and hypoparathyroidism. |
| first_indexed | 2024-03-12T13:28:52Z |
| format | Article |
| id | doaj.art-d4abadd634ed4e3aaaa56dbd20bb92db |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-12T13:28:52Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-d4abadd634ed4e3aaaa56dbd20bb92db2023-08-25T03:41:44ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-08-011410.3389/fendo.2023.12339561233956TOETVA parathyroid autofluorescence detection: hANDY-i endoscopy attachmentStefanie Seo0Khalid Mohamed Ali1Samantha A. Wolfe2Nimesh V. Nagururu3Andy S. Ding4Dipan Desai5R. Alex Harbison6Yoseph Kim7Bo Ning8Richard Jaepyeong Cha9Richard Jaepyeong Cha10Richard Jaepyeong Cha11Jonathon O. Russell12Department of Otolaryngology – Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, United StatesDepartment of Otolaryngology – Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, United StatesDepartment of Endocrine Surgery, University Health Network, Toronto, ON, CanadaDepartment of Otolaryngology – Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, United StatesDepartment of Otolaryngology – Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, United StatesDepartment of Otolaryngology – Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, United StatesDepartment of Otolaryngology – Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, United StatesDepartment of Research, Optosurgical, LLC, Columbia, MD, United StatesSheikh Zayed Institute, Children’s National Hospital, Washington, DC, United StatesDepartment of Research, Optosurgical, LLC, Columbia, MD, United StatesSheikh Zayed Institute, Children’s National Hospital, Washington, DC, United StatesDepartment of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC, United StatesDepartment of Otolaryngology – Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, United StatesBackgroundTreatment options for thyroid pathologies have expanded to include scarless and remote access methods such as the transoral endoscopic thyroidectomy vestibular approach (TOETVA). Currently, no standardized methods exist for locating parathyroid glands (PGs) in patients undergoing TOETVA, which can lead to parathyroid injury and subsequent hypocalcemia. This early feasibility study describes and evaluates the hANDY-i endoscopic attachment for detecting PGs in transoral thyroidectomy.MethodsWe used a prototype parathyroid autofluorescence imager (hANDY-i) that was mounted to a 10-mm 0-degree endoscope. The device delivers a split screen view of Red-green-blue (RGB) and near-infrared autofluorescence (NIRAF) which allows for simultaneous anatomical localization and fluorescence visualization of PGs during endoscopic thyroid dissection.ResultsOne cadaveric case and two patient cases were included in this study. The endoscopic hANDY-i imaging system successfully visualized PGs during all procedures.ConclusionThe ability to leverage parathyroid autofluorescence during TOETVA may lead to improved PG localization and preservation. Further human studies are needed to assess its effect on postoperative hypocalcemia and hypoparathyroidism.https://www.frontiersin.org/articles/10.3389/fendo.2023.1233956/fullparathyroid glandsnear-infrared autofluorescenceendoscopyremote-access thyroidectomythyroidectomy |
| spellingShingle | Stefanie Seo Khalid Mohamed Ali Samantha A. Wolfe Nimesh V. Nagururu Andy S. Ding Dipan Desai R. Alex Harbison Yoseph Kim Bo Ning Richard Jaepyeong Cha Richard Jaepyeong Cha Richard Jaepyeong Cha Jonathon O. Russell TOETVA parathyroid autofluorescence detection: hANDY-i endoscopy attachment Frontiers in Endocrinology parathyroid glands near-infrared autofluorescence endoscopy remote-access thyroidectomy thyroidectomy |
| title | TOETVA parathyroid autofluorescence detection: hANDY-i endoscopy attachment |
| title_full | TOETVA parathyroid autofluorescence detection: hANDY-i endoscopy attachment |
| title_fullStr | TOETVA parathyroid autofluorescence detection: hANDY-i endoscopy attachment |
| title_full_unstemmed | TOETVA parathyroid autofluorescence detection: hANDY-i endoscopy attachment |
| title_short | TOETVA parathyroid autofluorescence detection: hANDY-i endoscopy attachment |
| title_sort | toetva parathyroid autofluorescence detection handy i endoscopy attachment |
| topic | parathyroid glands near-infrared autofluorescence endoscopy remote-access thyroidectomy thyroidectomy |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1233956/full |
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