Knockdown of the fat mass and obesity gene disrupts cellular energy balance in a cell-type specific manner.

Knockdown of the fat mass and obesity gene disrupts cellular energy balance in a cell-type specific manner.

Recent studies suggest that FTO variants strongly correlate with obesity and mainly influence energy intake with little effect on the basal metabolic rate. We suggest that FTO influences eating behavior by modulating intracellular energy levels and downstream signaling mechanisms which control energ...

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Bibliographic Details
Main Authors: Ryan T Pitman, Jason T Fong, Penny Billman, Neelu Puri
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3367022?pdf=render

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