Structural Mechanisms and Drug Discovery Prospects of Rho GTPases

Structural Mechanisms and Drug Discovery Prospects of Rho GTPases

Rho GTPases regulate cellular morphology and dynamics, and some are key drivers of cancer progression. This superfamily offers attractive potential targets for therapeutic intervention, with RhoA, Rac1 and Cdc42 being prime examples. The challenges in developing agents that act on these signaling en...

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Bibliographic Details
Main Authors: Cameron C. Smithers, Michael Overduin
Format: Article
Language:English
Published: MDPI AG 2016-06-01
Series:Cells
Subjects:
cancer therapy
signal transduction
GTPase
Rho
RhoA
Rac1
Cdc42
GEF
Online Access:http://www.mdpi.com/2073-4409/5/2/26

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