Investigating neuroprotective roles of Bacopa monnieri extracts: Mechanistic insights and therapeutic implications
Bacopa monnieri (Brahmi) is a well-known perennial, creeping herb of the Indian Ayurveda system; it contains numerous bioactive phytoconstituents implicated in the therapeutic management of several life-threatening diseases. This herb was used by Ancient Vedic scholars due to its pharmacological eff...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | Biomedicine & Pharmacotherapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332222008587 |
| _version_ | 1811188049375133696 |
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| author | Urooj Fatima Sonam Roy Shahnawaz Ahmad Lamya Ahmed Al-Keridis Nawaf Alshammari Mohd Adnan Asimul Islam Md. Imtaiyaz Hassan |
| author_facet | Urooj Fatima Sonam Roy Shahnawaz Ahmad Lamya Ahmed Al-Keridis Nawaf Alshammari Mohd Adnan Asimul Islam Md. Imtaiyaz Hassan |
| author_sort | Urooj Fatima |
| collection | DOAJ |
| description | Bacopa monnieri (Brahmi) is a well-known perennial, creeping herb of the Indian Ayurveda system; it contains numerous bioactive phytoconstituents implicated in the therapeutic management of several life-threatening diseases. This herb was used by Ancient Vedic scholars due to its pharmacological effect, especially as a nerve tonic and nootropic booster. However, to better understand the roles of Bacopa monnieri extract (BME) in neurological disorders and memory-related diseases, it is necessary to understand its active phytochemical constituents and their molecular mechanisms. Several clinical studies suggested that BME have neuroprotective effects, making it worth revising a notable herb. Here we investigated the contours of BME's phytochemistry and pharmacological features, focusing on neuronal disorders. We further analyzed the underlying molecular mechanisms in therapeutic intervention. Various clinical concerns and synergistic potential of BME were explored for their effective use in cognition and neuroprotection. The generation of reactive oxygen species increases neuroinflammation and neurotoxicity and is associated with Tau and amyloid-beta (Aβ) aggregation, leading to a neurological disorder. Our findings provide deeper mechanistic insights into the neuroprotective roles of BME, which can be further implicated in the therapeutic management of neurological disorders and exerting cognitive-enhancing effects. |
| first_indexed | 2024-04-11T14:14:04Z |
| format | Article |
| id | doaj.art-d4aea4341d3b4f2d947cce4ecb1b2e83 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-11T14:14:04Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-d4aea4341d3b4f2d947cce4ecb1b2e832022-12-22T04:19:37ZengElsevierBiomedicine & Pharmacotherapy0753-33222022-09-01153113469Investigating neuroprotective roles of Bacopa monnieri extracts: Mechanistic insights and therapeutic implicationsUrooj Fatima0Sonam Roy1Shahnawaz Ahmad2Lamya Ahmed Al-Keridis3Nawaf Alshammari4Mohd Adnan5Asimul Islam6Md. Imtaiyaz Hassan7Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India; Corresponding authors.Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, IndiaSchool of Biotechnology, IFTM University, Lodhipur Rajpoot, Delhi Road, Moradabad 244001, IndiaDepartment of Biology, College of Science, Princess Nourah Bint Abdulrahman University, PO Box No. 84428, Riyadh 11671, Saudi ArabiaDepartment of Biology, College of Science, University of Hail, P.O. Box 2440, Hail, Saudi ArabiaDepartment of Biology, College of Science, University of Hail, P.O. Box 2440, Hail, Saudi ArabiaCentre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, IndiaCentre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India; Corresponding authors.Bacopa monnieri (Brahmi) is a well-known perennial, creeping herb of the Indian Ayurveda system; it contains numerous bioactive phytoconstituents implicated in the therapeutic management of several life-threatening diseases. This herb was used by Ancient Vedic scholars due to its pharmacological effect, especially as a nerve tonic and nootropic booster. However, to better understand the roles of Bacopa monnieri extract (BME) in neurological disorders and memory-related diseases, it is necessary to understand its active phytochemical constituents and their molecular mechanisms. Several clinical studies suggested that BME have neuroprotective effects, making it worth revising a notable herb. Here we investigated the contours of BME's phytochemistry and pharmacological features, focusing on neuronal disorders. We further analyzed the underlying molecular mechanisms in therapeutic intervention. Various clinical concerns and synergistic potential of BME were explored for their effective use in cognition and neuroprotection. The generation of reactive oxygen species increases neuroinflammation and neurotoxicity and is associated with Tau and amyloid-beta (Aβ) aggregation, leading to a neurological disorder. Our findings provide deeper mechanistic insights into the neuroprotective roles of BME, which can be further implicated in the therapeutic management of neurological disorders and exerting cognitive-enhancing effects.http://www.sciencedirect.com/science/article/pii/S0753332222008587NeuroprotectionTau aggregatesBacopa monnieriAlzheimer's diseaseReactive Oxygen SpeciesBacosides |
| spellingShingle | Urooj Fatima Sonam Roy Shahnawaz Ahmad Lamya Ahmed Al-Keridis Nawaf Alshammari Mohd Adnan Asimul Islam Md. Imtaiyaz Hassan Investigating neuroprotective roles of Bacopa monnieri extracts: Mechanistic insights and therapeutic implications Biomedicine & Pharmacotherapy Neuroprotection Tau aggregates Bacopa monnieri Alzheimer's disease Reactive Oxygen Species Bacosides |
| title | Investigating neuroprotective roles of Bacopa monnieri extracts: Mechanistic insights and therapeutic implications |
| title_full | Investigating neuroprotective roles of Bacopa monnieri extracts: Mechanistic insights and therapeutic implications |
| title_fullStr | Investigating neuroprotective roles of Bacopa monnieri extracts: Mechanistic insights and therapeutic implications |
| title_full_unstemmed | Investigating neuroprotective roles of Bacopa monnieri extracts: Mechanistic insights and therapeutic implications |
| title_short | Investigating neuroprotective roles of Bacopa monnieri extracts: Mechanistic insights and therapeutic implications |
| title_sort | investigating neuroprotective roles of bacopa monnieri extracts mechanistic insights and therapeutic implications |
| topic | Neuroprotection Tau aggregates Bacopa monnieri Alzheimer's disease Reactive Oxygen Species Bacosides |
| url | http://www.sciencedirect.com/science/article/pii/S0753332222008587 |
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