Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma
Chimeric antigen receptor (CAR)-based therapy for the treatment of liver cancer represents a promising therapeutic strategy. Here the authors show that CD147-targeting CAR-NK or CAR-T can induce anti-tumor activity against hepatocellular carcinoma in vitro and in vivo.
Bibliographic Details
| Main Authors: |
Hsiang-chi Tseng,
Wei Xiong,
Saiaditya Badeti,
Yan Yang,
Minh Ma,
Ting Liu,
Carlos A. Ramos,
Gianpietro Dotti,
Luke Fritzky,
Jie-gen Jiang,
Qing Yi,
James Guarrera,
Wei-Xing Zong,
Chen Liu,
Dongfang Liu |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2020-09-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-020-18444-2
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