Influence of the internal structure of straight microchannels on inertial transport behavior of particles
The rapid advancement of Micro-Electro-Mechanical Systems (MEMS) technology has established microfluidics as a pivotal field. This technology marks the onset of a new era in various applications, including drug testing, cell culture, and disease monitoring, underscoring its extensive practicality an...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024056081 |
| _version_ | 1797203057369415680 |
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| author | Hua Dong Longrun Huang Liang Zhao |
| author_facet | Hua Dong Longrun Huang Liang Zhao |
| author_sort | Hua Dong |
| collection | DOAJ |
| description | The rapid advancement of Micro-Electro-Mechanical Systems (MEMS) technology has established microfluidics as a pivotal field. This technology marks the onset of a new era in various applications, including drug testing, cell culture, and disease monitoring, underscoring its extensive practicality and potential for future exploration. This research delves into the intricate behavior of particle inertial migration within microchannels, particularly focusing on the impact of different channel structures and Reynolds numbers (Re). Our studies reveal that particles in microchannels with one-sided sharp-cornered microstructures migrate towards the sharp corner at a relative position of 0.4 under low flow rates, and towards the straight wall side at a relative position of 0.8 under high flow rates. The migration pattern of equilibrium positions varies with different arrangements of sharp-corner structures, achieving stability at the channel's center only when the sharp corners are symmetrically arranged on both sides. Our investigation into the shape of microstructures indicates that sharp-cornered structures generate a more stable secondary flow compared to rectangular and semi-circular structures, preventing particle aggregation at the outlet. To address the challenges associated with handling variable cross-section geometries and solid-wall boundaries in dissipative particle dynamics methods effectively, we have developed a dissipative particle dynamics model specifically for analyzing such microchannels. Building upon our previous research, this model introduces a conservative force coefficient for particles within the microstructured region and an interaction zone that only involves repulsive forces, aligning well with experimental outcomes. Through the study of microstructures' geometric shapes, this paper offers guidance for designing microchannels for particle enrichment. Furthermore, the dissipative particle dynamics model established for the particle flow and solid structure interaction within microstructured channels provides insights into the mesoscale dynamics of liquid-solid two-phase flow and particle motion. In conclusion, this paper aims to enhance particle motion sample preparation techniques, thereby broadening the scope of microfluidic applications in the biomedical field. |
| first_indexed | 2024-04-24T08:13:17Z |
| format | Article |
| id | doaj.art-d4b01c3be1054a0ba9d2b88527929b6d |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-24T08:13:17Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-d4b01c3be1054a0ba9d2b88527929b6d2024-04-17T04:49:33ZengElsevierHeliyon2405-84402024-04-01108e29577Influence of the internal structure of straight microchannels on inertial transport behavior of particlesHua Dong0Longrun Huang1Liang Zhao2State Key Laboratory of Multiphase Flow in Power Engineering, Xi'an Jiaotong University, Xi'an, 710049, PR China; Corresponding author.School of Mechanical Engineering, Xi'an Jiaotong University, Xi'an, 710049, PR ChinaState Key Laboratory of Multiphase Flow in Power Engineering, Xi'an Jiaotong University, Xi'an, 710049, PR ChinaThe rapid advancement of Micro-Electro-Mechanical Systems (MEMS) technology has established microfluidics as a pivotal field. This technology marks the onset of a new era in various applications, including drug testing, cell culture, and disease monitoring, underscoring its extensive practicality and potential for future exploration. This research delves into the intricate behavior of particle inertial migration within microchannels, particularly focusing on the impact of different channel structures and Reynolds numbers (Re). Our studies reveal that particles in microchannels with one-sided sharp-cornered microstructures migrate towards the sharp corner at a relative position of 0.4 under low flow rates, and towards the straight wall side at a relative position of 0.8 under high flow rates. The migration pattern of equilibrium positions varies with different arrangements of sharp-corner structures, achieving stability at the channel's center only when the sharp corners are symmetrically arranged on both sides. Our investigation into the shape of microstructures indicates that sharp-cornered structures generate a more stable secondary flow compared to rectangular and semi-circular structures, preventing particle aggregation at the outlet. To address the challenges associated with handling variable cross-section geometries and solid-wall boundaries in dissipative particle dynamics methods effectively, we have developed a dissipative particle dynamics model specifically for analyzing such microchannels. Building upon our previous research, this model introduces a conservative force coefficient for particles within the microstructured region and an interaction zone that only involves repulsive forces, aligning well with experimental outcomes. Through the study of microstructures' geometric shapes, this paper offers guidance for designing microchannels for particle enrichment. Furthermore, the dissipative particle dynamics model established for the particle flow and solid structure interaction within microstructured channels provides insights into the mesoscale dynamics of liquid-solid two-phase flow and particle motion. In conclusion, this paper aims to enhance particle motion sample preparation techniques, thereby broadening the scope of microfluidic applications in the biomedical field.http://www.sciencedirect.com/science/article/pii/S2405844024056081Reynolds numberParticleMicrochannelBiomedicine |
| spellingShingle | Hua Dong Longrun Huang Liang Zhao Influence of the internal structure of straight microchannels on inertial transport behavior of particles Heliyon Reynolds number Particle Microchannel Biomedicine |
| title | Influence of the internal structure of straight microchannels on inertial transport behavior of particles |
| title_full | Influence of the internal structure of straight microchannels on inertial transport behavior of particles |
| title_fullStr | Influence of the internal structure of straight microchannels on inertial transport behavior of particles |
| title_full_unstemmed | Influence of the internal structure of straight microchannels on inertial transport behavior of particles |
| title_short | Influence of the internal structure of straight microchannels on inertial transport behavior of particles |
| title_sort | influence of the internal structure of straight microchannels on inertial transport behavior of particles |
| topic | Reynolds number Particle Microchannel Biomedicine |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024056081 |
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