Molecular and cellular mechanisms involved in tissue-specific metabolic modulation by SARS-CoV-2
Coronavirus disease 2019 (COVID-19) is triggered by the SARS-CoV-2, which is able to infect and cause dysfunction not only in lungs, but also in multiple organs, including central nervous system, skeletal muscle, kidneys, heart, liver, and intestine. Several metabolic disturbances are associated wit...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2022.1037467/full |
| _version_ | 1811232809257271296 |
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| author | Alef Aragão Carneiro dos Santos Luiz Eduardo Rodrigues Amanda Lins Alecrim-Zeza Liliane de Araújo Ferreira Caio dos Santos Trettel Gabriela Mandú Gimenes Adelson Fernandes da Silva Celso Pereira Batista Sousa-Filho Tamires Duarte Afonso Serdan Tamires Duarte Afonso Serdan Adriana Cristina Levada-Pires Elaine Hatanaka Fernanda Teixeira Borges Fernanda Teixeira Borges Marcelo Paes de Barros Maria Fernanda Cury-Boaventura Gisele Lopes Bertolini Priscila Cassolla Gabriel Nasri Marzuca-Nassr Kaio Fernando Vitzel Tania Cristina Pithon-Curi Laureane Nunes Masi Rui Curi Rui Curi Renata Gorjao Sandro Massao Hirabara |
| author_facet | Alef Aragão Carneiro dos Santos Luiz Eduardo Rodrigues Amanda Lins Alecrim-Zeza Liliane de Araújo Ferreira Caio dos Santos Trettel Gabriela Mandú Gimenes Adelson Fernandes da Silva Celso Pereira Batista Sousa-Filho Tamires Duarte Afonso Serdan Tamires Duarte Afonso Serdan Adriana Cristina Levada-Pires Elaine Hatanaka Fernanda Teixeira Borges Fernanda Teixeira Borges Marcelo Paes de Barros Maria Fernanda Cury-Boaventura Gisele Lopes Bertolini Priscila Cassolla Gabriel Nasri Marzuca-Nassr Kaio Fernando Vitzel Tania Cristina Pithon-Curi Laureane Nunes Masi Rui Curi Rui Curi Renata Gorjao Sandro Massao Hirabara |
| author_sort | Alef Aragão Carneiro dos Santos |
| collection | DOAJ |
| description | Coronavirus disease 2019 (COVID-19) is triggered by the SARS-CoV-2, which is able to infect and cause dysfunction not only in lungs, but also in multiple organs, including central nervous system, skeletal muscle, kidneys, heart, liver, and intestine. Several metabolic disturbances are associated with cell damage or tissue injury, but the mechanisms involved are not yet fully elucidated. Some potential mechanisms involved in the COVID-19-induced tissue dysfunction are proposed, such as: (a) High expression and levels of proinflammatory cytokines, including TNF-α IL-6, IL-1β, INF-α and INF-β, increasing the systemic and tissue inflammatory state; (b) Induction of oxidative stress due to redox imbalance, resulting in cell injury or death induced by elevated production of reactive oxygen species; and (c) Deregulation of the renin-angiotensin-aldosterone system, exacerbating the inflammatory and oxidative stress responses. In this review, we discuss the main metabolic disturbances observed in different target tissues of SARS-CoV-2 and the potential mechanisms involved in these changes associated with the tissue dysfunction. |
| first_indexed | 2024-04-12T11:10:31Z |
| format | Article |
| id | doaj.art-d4b27444458d4cd588d5b417490007a9 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-12T11:10:31Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-d4b27444458d4cd588d5b417490007a92022-12-22T03:35:38ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-11-011310.3389/fmicb.2022.10374671037467Molecular and cellular mechanisms involved in tissue-specific metabolic modulation by SARS-CoV-2Alef Aragão Carneiro dos Santos0Luiz Eduardo Rodrigues1Amanda Lins Alecrim-Zeza2Liliane de Araújo Ferreira3Caio dos Santos Trettel4Gabriela Mandú Gimenes5Adelson Fernandes da Silva6Celso Pereira Batista Sousa-Filho7Tamires Duarte Afonso Serdan8Tamires Duarte Afonso Serdan9Adriana Cristina Levada-Pires10Elaine Hatanaka11Fernanda Teixeira Borges12Fernanda Teixeira Borges13Marcelo Paes de Barros14Maria Fernanda Cury-Boaventura15Gisele Lopes Bertolini16Priscila Cassolla17Gabriel Nasri Marzuca-Nassr18Kaio Fernando Vitzel19Tania Cristina Pithon-Curi20Laureane Nunes Masi21Rui Curi22Rui Curi23Renata Gorjao24Sandro Massao Hirabara25Programa de Pós-graduação Interdisciplinar em Ciências da Saúde, Universidade Cruzeiro do Sul, São Paulo, São Paulo, BrazilPrograma de Pós-graduação Interdisciplinar em Ciências da Saúde, Universidade Cruzeiro do Sul, São Paulo, São Paulo, BrazilPrograma de Pós-graduação Interdisciplinar em Ciências da Saúde, Universidade Cruzeiro do Sul, São Paulo, São Paulo, BrazilPrograma de Pós-graduação Interdisciplinar em Ciências da Saúde, Universidade Cruzeiro do Sul, São Paulo, São Paulo, BrazilPrograma de Pós-graduação Interdisciplinar em Ciências da Saúde, Universidade Cruzeiro do Sul, São Paulo, São Paulo, BrazilPrograma de Pós-graduação Interdisciplinar em Ciências da Saúde, Universidade Cruzeiro do Sul, São Paulo, São Paulo, BrazilPrograma de Pós-graduação Interdisciplinar em Ciências da Saúde, Universidade Cruzeiro do Sul, São Paulo, São Paulo, BrazilPrograma de Pós-graduação Interdisciplinar em Ciências da Saúde, Universidade Cruzeiro do Sul, São Paulo, São Paulo, BrazilPrograma de Pós-graduação Interdisciplinar em Ciências da Saúde, Universidade Cruzeiro do Sul, São Paulo, São Paulo, BrazilDepartment of Molecular Pathobiology, University of New York, New York, NY, United StatesPrograma de Pós-graduação Interdisciplinar em Ciências da Saúde, Universidade Cruzeiro do Sul, São Paulo, São Paulo, BrazilPrograma de Pós-graduação Interdisciplinar em Ciências da Saúde, Universidade Cruzeiro do Sul, São Paulo, São Paulo, BrazilPrograma de Pós-graduação Interdisciplinar em Ciências da Saúde, Universidade Cruzeiro do Sul, São Paulo, São Paulo, BrazilDivisão de Nefrologia, Departamento de Medicina, Universidade Federal de São Paulo, São Paulo, SP, BrazilPrograma de Pós-graduação Interdisciplinar em Ciências da Saúde, Universidade Cruzeiro do Sul, São Paulo, São Paulo, BrazilPrograma de Pós-graduação Interdisciplinar em Ciências da Saúde, Universidade Cruzeiro do Sul, São Paulo, São Paulo, BrazilDepartment of Physiological Sciences, Biological Science Center, State University of Londrina, Londrina, PR, BrazilDepartment of Physiological Sciences, Biological Science Center, State University of Londrina, Londrina, PR, BrazilDepartamento de Ciencias de la Rehabilitación, Universidad de La Frontera, Temuco, ChileSchool of Health Sciences, College of Health, Massey University, Auckland, New ZealandPrograma de Pós-graduação Interdisciplinar em Ciências da Saúde, Universidade Cruzeiro do Sul, São Paulo, São Paulo, BrazilPrograma de Pós-graduação Interdisciplinar em Ciências da Saúde, Universidade Cruzeiro do Sul, São Paulo, São Paulo, BrazilPrograma de Pós-graduação Interdisciplinar em Ciências da Saúde, Universidade Cruzeiro do Sul, São Paulo, São Paulo, BrazilInstituto Butantan, São Paulo, BrazilPrograma de Pós-graduação Interdisciplinar em Ciências da Saúde, Universidade Cruzeiro do Sul, São Paulo, São Paulo, BrazilPrograma de Pós-graduação Interdisciplinar em Ciências da Saúde, Universidade Cruzeiro do Sul, São Paulo, São Paulo, BrazilCoronavirus disease 2019 (COVID-19) is triggered by the SARS-CoV-2, which is able to infect and cause dysfunction not only in lungs, but also in multiple organs, including central nervous system, skeletal muscle, kidneys, heart, liver, and intestine. Several metabolic disturbances are associated with cell damage or tissue injury, but the mechanisms involved are not yet fully elucidated. Some potential mechanisms involved in the COVID-19-induced tissue dysfunction are proposed, such as: (a) High expression and levels of proinflammatory cytokines, including TNF-α IL-6, IL-1β, INF-α and INF-β, increasing the systemic and tissue inflammatory state; (b) Induction of oxidative stress due to redox imbalance, resulting in cell injury or death induced by elevated production of reactive oxygen species; and (c) Deregulation of the renin-angiotensin-aldosterone system, exacerbating the inflammatory and oxidative stress responses. In this review, we discuss the main metabolic disturbances observed in different target tissues of SARS-CoV-2 and the potential mechanisms involved in these changes associated with the tissue dysfunction.https://www.frontiersin.org/articles/10.3389/fmicb.2022.1037467/fullmetabolisminflammationoxidative stressrenin-angiotensin-aldosterone systemSARS-CoV-2 |
| spellingShingle | Alef Aragão Carneiro dos Santos Luiz Eduardo Rodrigues Amanda Lins Alecrim-Zeza Liliane de Araújo Ferreira Caio dos Santos Trettel Gabriela Mandú Gimenes Adelson Fernandes da Silva Celso Pereira Batista Sousa-Filho Tamires Duarte Afonso Serdan Tamires Duarte Afonso Serdan Adriana Cristina Levada-Pires Elaine Hatanaka Fernanda Teixeira Borges Fernanda Teixeira Borges Marcelo Paes de Barros Maria Fernanda Cury-Boaventura Gisele Lopes Bertolini Priscila Cassolla Gabriel Nasri Marzuca-Nassr Kaio Fernando Vitzel Tania Cristina Pithon-Curi Laureane Nunes Masi Rui Curi Rui Curi Renata Gorjao Sandro Massao Hirabara Molecular and cellular mechanisms involved in tissue-specific metabolic modulation by SARS-CoV-2 Frontiers in Microbiology metabolism inflammation oxidative stress renin-angiotensin-aldosterone system SARS-CoV-2 |
| title | Molecular and cellular mechanisms involved in tissue-specific metabolic modulation by SARS-CoV-2 |
| title_full | Molecular and cellular mechanisms involved in tissue-specific metabolic modulation by SARS-CoV-2 |
| title_fullStr | Molecular and cellular mechanisms involved in tissue-specific metabolic modulation by SARS-CoV-2 |
| title_full_unstemmed | Molecular and cellular mechanisms involved in tissue-specific metabolic modulation by SARS-CoV-2 |
| title_short | Molecular and cellular mechanisms involved in tissue-specific metabolic modulation by SARS-CoV-2 |
| title_sort | molecular and cellular mechanisms involved in tissue specific metabolic modulation by sars cov 2 |
| topic | metabolism inflammation oxidative stress renin-angiotensin-aldosterone system SARS-CoV-2 |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2022.1037467/full |
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