An oral French maritime pine bark extract improves hair density in menopausal women: A randomized, placebo‐controlled, double blind intervention study
Abstract Background and Aims Female pattern hair loss affects females of all ages with a trend to increase after menopause. This disorder may have significant psychological impact and lead to anxiety and depression. Objective In a single center, double blind, randomized, placebo‐controlled study, th...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Health Science Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/hsr2.1045 |
| _version_ | 1797737738043129856 |
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| author | Carr Cai Bill Zeng Lydia Lin Miranda Zheng Carolina Burki Susanne Grether‐Beck Jean Krutmann |
| author_facet | Carr Cai Bill Zeng Lydia Lin Miranda Zheng Carolina Burki Susanne Grether‐Beck Jean Krutmann |
| author_sort | Carr Cai |
| collection | DOAJ |
| description | Abstract Background and Aims Female pattern hair loss affects females of all ages with a trend to increase after menopause. This disorder may have significant psychological impact and lead to anxiety and depression. Objective In a single center, double blind, randomized, placebo‐controlled study, the effects of oral Pycnogenol® intake (3 × 50 mg/day for a total of 6 months) on hair density, scalp microcirculation, and a variety of skin physiological parameters was studied in Han Chinese menopausal women (N = 76) in Shanghai, China. Methods Measurements were taken at the beginning and after 2 and 6 months, respectively. Hair density was determined by digital photographs and further evaluated by Trichoscan software. Transepidermal water loss was measured by a humidity sensor in a closed chamber on the skin surface. Changes in microcirculation were detected as resting flux on the scalp by reflection photoplethysmography. Results Pycnogenol® intake significantly increased hair density by 30% and 23% after 2 and 6 months of treatment, respectively, as detected by Trichoscan® evaluation of digital photographs. Interestingly, photoplethysmography revealed that this beneficial effect was associated with a decrease in resting flux of the scalp skin, which might indicate an improvement of microcirculation. None of these effects were observed in the placebo taking group. In addition, a significant transient decrease of transepidermal water loss was observed in scalp skin under Pycnogenol,® but not placebo treatment. Conclusion Oral intake of Pycnogenol® might have the potential to reduce hair loss in postmenopausal women. |
| first_indexed | 2024-03-12T13:33:44Z |
| format | Article |
| id | doaj.art-d4b34f26578f4f2fba8c2730b9227306 |
| institution | Directory Open Access Journal |
| issn | 2398-8835 |
| language | English |
| last_indexed | 2024-03-12T13:33:44Z |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj.art-d4b34f26578f4f2fba8c2730b92273062023-08-24T06:32:46ZengWileyHealth Science Reports2398-88352023-01-0161n/an/a10.1002/hsr2.1045An oral French maritime pine bark extract improves hair density in menopausal women: A randomized, placebo‐controlled, double blind intervention studyCarr Cai0Bill Zeng1Lydia Lin2Miranda Zheng3Carolina Burki4Susanne Grether‐Beck5Jean Krutmann6Intertek Testing Services Ltd Shanghai ChinaIntertek Testing Services Ltd Shanghai ChinaIntertek Testing Services Ltd Shanghai ChinaIntertek Testing Services Ltd Shanghai ChinaHorphag Research Geneva SwitzerlandIUF ‐ Leibniz Research Institute for Environmental Medicine Düsseldorf GermanyIUF ‐ Leibniz Research Institute for Environmental Medicine Düsseldorf GermanyAbstract Background and Aims Female pattern hair loss affects females of all ages with a trend to increase after menopause. This disorder may have significant psychological impact and lead to anxiety and depression. Objective In a single center, double blind, randomized, placebo‐controlled study, the effects of oral Pycnogenol® intake (3 × 50 mg/day for a total of 6 months) on hair density, scalp microcirculation, and a variety of skin physiological parameters was studied in Han Chinese menopausal women (N = 76) in Shanghai, China. Methods Measurements were taken at the beginning and after 2 and 6 months, respectively. Hair density was determined by digital photographs and further evaluated by Trichoscan software. Transepidermal water loss was measured by a humidity sensor in a closed chamber on the skin surface. Changes in microcirculation were detected as resting flux on the scalp by reflection photoplethysmography. Results Pycnogenol® intake significantly increased hair density by 30% and 23% after 2 and 6 months of treatment, respectively, as detected by Trichoscan® evaluation of digital photographs. Interestingly, photoplethysmography revealed that this beneficial effect was associated with a decrease in resting flux of the scalp skin, which might indicate an improvement of microcirculation. None of these effects were observed in the placebo taking group. In addition, a significant transient decrease of transepidermal water loss was observed in scalp skin under Pycnogenol,® but not placebo treatment. Conclusion Oral intake of Pycnogenol® might have the potential to reduce hair loss in postmenopausal women.https://doi.org/10.1002/hsr2.1045female patternhair densitymicrocirculationplacebo‐controlledPycnogenol® |
| spellingShingle | Carr Cai Bill Zeng Lydia Lin Miranda Zheng Carolina Burki Susanne Grether‐Beck Jean Krutmann An oral French maritime pine bark extract improves hair density in menopausal women: A randomized, placebo‐controlled, double blind intervention study Health Science Reports female pattern hair density microcirculation placebo‐controlled Pycnogenol® |
| title | An oral French maritime pine bark extract improves hair density in menopausal women: A randomized, placebo‐controlled, double blind intervention study |
| title_full | An oral French maritime pine bark extract improves hair density in menopausal women: A randomized, placebo‐controlled, double blind intervention study |
| title_fullStr | An oral French maritime pine bark extract improves hair density in menopausal women: A randomized, placebo‐controlled, double blind intervention study |
| title_full_unstemmed | An oral French maritime pine bark extract improves hair density in menopausal women: A randomized, placebo‐controlled, double blind intervention study |
| title_short | An oral French maritime pine bark extract improves hair density in menopausal women: A randomized, placebo‐controlled, double blind intervention study |
| title_sort | oral french maritime pine bark extract improves hair density in menopausal women a randomized placebo controlled double blind intervention study |
| topic | female pattern hair density microcirculation placebo‐controlled Pycnogenol® |
| url | https://doi.org/10.1002/hsr2.1045 |
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