Factors associated with residual urine volume preservation in patients undergoing hemodialysis for end-stage kidney disease in Kinshasa
Abstract Background Decreased residual urine volume (RUV) is associated with higher mortality in hemodialysis (HD). However, few studies have examined RUV in patients on HD in Sub-Saharan Africa. The aim of this study was to identify predictors of RUV among incident hemodialysis patients in Kinshasa...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-03-01
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| Series: | BMC Nephrology |
| Online Access: | http://link.springer.com/article/10.1186/s12882-018-0865-x |
| _version_ | 1819052933390532608 |
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| author | Vieux Momeme Mokoli Ernest Kiswaya Sumaili François Bompeka Lepira Fiston Ikwa Ndol Mbutiwi Jean Robert Rissassy Makulo Justine Busanga Bukabau Patrick Parmba Izeidi Jeannine Losa Luse Stéphane Kalambay Mukendi Désiré Kulimba Mashinda Nazaire Mangani Nseka |
| author_facet | Vieux Momeme Mokoli Ernest Kiswaya Sumaili François Bompeka Lepira Fiston Ikwa Ndol Mbutiwi Jean Robert Rissassy Makulo Justine Busanga Bukabau Patrick Parmba Izeidi Jeannine Losa Luse Stéphane Kalambay Mukendi Désiré Kulimba Mashinda Nazaire Mangani Nseka |
| author_sort | Vieux Momeme Mokoli |
| collection | DOAJ |
| description | Abstract Background Decreased residual urine volume (RUV) is associated with higher mortality in hemodialysis (HD). However, few studies have examined RUV in patients on HD in Sub-Saharan Africa. The aim of this study was to identify predictors of RUV among incident hemodialysis patients in Kinshasa. Methods This historical cohort study enrolled 250 patients with ESRD undergoing hemodialysis between January 2007 and July 2013 in two hemodialysis centers in Kinshasa. RUV were collected over 24 h at the initiation of HD and 6 and 12 months later during the interdialytic period. We compared the baseline characteristics of the patients according to their initial RUV (≤ 500 ml/day vs > 500 ml/day) using Student’s t, Mann-Whitney U and Chi2 tests. Linear mixed-effects models were used to search for predictors of decreased RUV by adding potentially predictive baseline covariates of the evolution of RUV to the effect of time: age, sex, diabetes mellitus, hypertension, diastolic blood pressure, diuretics, angiotensin conversion enzyme inhibitors (ACEI), angiotensin receptor blockers, hypovolemia, chronic tubulointerstitial nephropathy, left ventricular hypertrophy and initial hemodialysis characteristic. A value of p < 0.05 was considered the threshold of statistical significance. Results The majority of hemodialysis patients were male (68.8%, sex ratio 2.2), with a mean age of 52.5 ± 12.3 years. The population’s RUV decreased with time, but with a slight deceleration. The mean RUV values were 680 ± 537 ml/day, 558 ± 442 ml/day and 499 ± 475 ml/day, respectively, at the initiation of HD and at 6 and 12 months later. The use of ACEI at the initiation of HD (beta coefficient 219.5, p < 0.001) and the presence of chronic tubulointerstitial nephropathy (beta coefficient 291.8, p = 0.007) were significantly associated with RUV preservation over time. In contrast, the presence of left ventricular hypertrophy at the initiation of HD was significantly associated with decreased RUV over time (beta coefficient − 133.9, p = 0.029). Conclusions Among incident hemodialysis patients, the use of ACEI, the presence of chronic tubulointerstitial nephropathy and reduced left ventricular hypertrophy are associated with greater RUV preservation in the first year of dialysis. |
| first_indexed | 2024-12-21T12:27:42Z |
| format | Article |
| id | doaj.art-d4b36b2483ad423d8997aa7ce4e37dc6 |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-12-21T12:27:42Z |
| publishDate | 2018-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-d4b36b2483ad423d8997aa7ce4e37dc62022-12-21T19:04:08ZengBMCBMC Nephrology1471-23692018-03-011911910.1186/s12882-018-0865-xFactors associated with residual urine volume preservation in patients undergoing hemodialysis for end-stage kidney disease in KinshasaVieux Momeme Mokoli0Ernest Kiswaya Sumaili1François Bompeka Lepira2Fiston Ikwa Ndol Mbutiwi3Jean Robert Rissassy Makulo4Justine Busanga Bukabau5Patrick Parmba Izeidi6Jeannine Losa Luse7Stéphane Kalambay Mukendi8Désiré Kulimba Mashinda9Nazaire Mangani Nseka10Division of Nephrology, University of KinshasaDivision of Nephrology, University of KinshasaDivision of Nephrology, University of KinshasaFaculty of medicine, University of KikwitDivision of Nephrology, University of KinshasaDivision of Nephrology, University of KinshasaDivision of Nephrology, University of KinshasaHemodialysis Unit of Provincial General Hospital of KinshasaHemodialysis Unit of Provincial General Hospital of KinshasaSchool of Public Health, University of KinshasaDivision of Nephrology, University of KinshasaAbstract Background Decreased residual urine volume (RUV) is associated with higher mortality in hemodialysis (HD). However, few studies have examined RUV in patients on HD in Sub-Saharan Africa. The aim of this study was to identify predictors of RUV among incident hemodialysis patients in Kinshasa. Methods This historical cohort study enrolled 250 patients with ESRD undergoing hemodialysis between January 2007 and July 2013 in two hemodialysis centers in Kinshasa. RUV were collected over 24 h at the initiation of HD and 6 and 12 months later during the interdialytic period. We compared the baseline characteristics of the patients according to their initial RUV (≤ 500 ml/day vs > 500 ml/day) using Student’s t, Mann-Whitney U and Chi2 tests. Linear mixed-effects models were used to search for predictors of decreased RUV by adding potentially predictive baseline covariates of the evolution of RUV to the effect of time: age, sex, diabetes mellitus, hypertension, diastolic blood pressure, diuretics, angiotensin conversion enzyme inhibitors (ACEI), angiotensin receptor blockers, hypovolemia, chronic tubulointerstitial nephropathy, left ventricular hypertrophy and initial hemodialysis characteristic. A value of p < 0.05 was considered the threshold of statistical significance. Results The majority of hemodialysis patients were male (68.8%, sex ratio 2.2), with a mean age of 52.5 ± 12.3 years. The population’s RUV decreased with time, but with a slight deceleration. The mean RUV values were 680 ± 537 ml/day, 558 ± 442 ml/day and 499 ± 475 ml/day, respectively, at the initiation of HD and at 6 and 12 months later. The use of ACEI at the initiation of HD (beta coefficient 219.5, p < 0.001) and the presence of chronic tubulointerstitial nephropathy (beta coefficient 291.8, p = 0.007) were significantly associated with RUV preservation over time. In contrast, the presence of left ventricular hypertrophy at the initiation of HD was significantly associated with decreased RUV over time (beta coefficient − 133.9, p = 0.029). Conclusions Among incident hemodialysis patients, the use of ACEI, the presence of chronic tubulointerstitial nephropathy and reduced left ventricular hypertrophy are associated with greater RUV preservation in the first year of dialysis.http://link.springer.com/article/10.1186/s12882-018-0865-x |
| spellingShingle | Vieux Momeme Mokoli Ernest Kiswaya Sumaili François Bompeka Lepira Fiston Ikwa Ndol Mbutiwi Jean Robert Rissassy Makulo Justine Busanga Bukabau Patrick Parmba Izeidi Jeannine Losa Luse Stéphane Kalambay Mukendi Désiré Kulimba Mashinda Nazaire Mangani Nseka Factors associated with residual urine volume preservation in patients undergoing hemodialysis for end-stage kidney disease in Kinshasa BMC Nephrology |
| title | Factors associated with residual urine volume preservation in patients undergoing hemodialysis for end-stage kidney disease in Kinshasa |
| title_full | Factors associated with residual urine volume preservation in patients undergoing hemodialysis for end-stage kidney disease in Kinshasa |
| title_fullStr | Factors associated with residual urine volume preservation in patients undergoing hemodialysis for end-stage kidney disease in Kinshasa |
| title_full_unstemmed | Factors associated with residual urine volume preservation in patients undergoing hemodialysis for end-stage kidney disease in Kinshasa |
| title_short | Factors associated with residual urine volume preservation in patients undergoing hemodialysis for end-stage kidney disease in Kinshasa |
| title_sort | factors associated with residual urine volume preservation in patients undergoing hemodialysis for end stage kidney disease in kinshasa |
| url | http://link.springer.com/article/10.1186/s12882-018-0865-x |
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