Evaluation of the association between exosomal levels and female reproductive system and fertility outcome during aging: a systematic review protocol
Abstract Background Exosomes may have critical roles in the maternal-embryo cross-talk for the recognition and maintenance of pregnancy during maternal aging. Exosomes have the capability to carry developmental signaling molecules with the ability to modulate gene expressions and affect growth and r...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-11-01
|
| Series: | Systematic Reviews |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13643-019-1228-9 |
| _version_ | 1818327754199793664 |
|---|---|
| author | Halimeh Mobarak Reza Rahbarghazi Francesca Lolicato Mohammad Heidarpour Fariba Pashazadeh Mohammad Nouri Mahdi Mahdipour |
| author_facet | Halimeh Mobarak Reza Rahbarghazi Francesca Lolicato Mohammad Heidarpour Fariba Pashazadeh Mohammad Nouri Mahdi Mahdipour |
| author_sort | Halimeh Mobarak |
| collection | DOAJ |
| description | Abstract Background Exosomes may have critical roles in the maternal-embryo cross-talk for the recognition and maintenance of pregnancy during maternal aging. Exosomes have the capability to carry developmental signaling molecules with the ability to modulate gene expressions and affect growth and regulation of embryo during pregnancy. Systematic review aims to evaluate age-related alterations in the exosomal content and functions that can influence the reproductive performance in human and animal models as conveyors of senescence signals. Methods A literature search of electronic databases including MEDLINE (PubMed), Embase, ProQuest, Scopus, Google Scholar, WHO, SID, MAGIRAN, and Barakat will be conducted. Following the online search, articles will be screened by two independent reviewers according to inclusion and exclusion criteria. Eligible studies will be critically appraised by reviewers at the study level for methodological quality using Joanna Briggs Institute’s standardized critical appraisal tools. The extracted data from selected studies will cover the study populations, methods, current evidence about the physiological role of extracellular vesicles and exosomes in reproductive system, relevant outcomes, and possible conclusions about the effectiveness of exposure. Discussion Regarding the role of exosomes and their cargoes in the function of reproductive tract, the possible beneficial or adverse effects following exosomal administration from younger women to older women will be evaluated in the systematic review. As a result, exosome therapy could be suggested as a novel therapeutic agent if the favorable results are identified. |
| first_indexed | 2024-12-13T12:21:17Z |
| format | Article |
| id | doaj.art-d4b43e8cb29442cfabfae6bd1f8d1b4b |
| institution | Directory Open Access Journal |
| issn | 2046-4053 |
| language | English |
| last_indexed | 2024-12-13T12:21:17Z |
| publishDate | 2019-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Systematic Reviews |
| spelling | doaj.art-d4b43e8cb29442cfabfae6bd1f8d1b4b2022-12-21T23:46:35ZengBMCSystematic Reviews2046-40532019-11-01811610.1186/s13643-019-1228-9Evaluation of the association between exosomal levels and female reproductive system and fertility outcome during aging: a systematic review protocolHalimeh Mobarak0Reza Rahbarghazi1Francesca Lolicato2Mohammad Heidarpour3Fariba Pashazadeh4Mohammad Nouri5Mahdi Mahdipour6Department of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of MashhadStem Cell Research Center, Tabriz University of Medical SciencesFollicle Biology Laboratory, UZ Brussel, Vrije Universiteit BrusselDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of MashhadResearch Center for Evidence-Based Medicine, Health Management and Safety Promotion Research Institute, Tabriz University of Medical SciencesDepartment of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical SciencesStem Cell Research Center, Tabriz University of Medical SciencesAbstract Background Exosomes may have critical roles in the maternal-embryo cross-talk for the recognition and maintenance of pregnancy during maternal aging. Exosomes have the capability to carry developmental signaling molecules with the ability to modulate gene expressions and affect growth and regulation of embryo during pregnancy. Systematic review aims to evaluate age-related alterations in the exosomal content and functions that can influence the reproductive performance in human and animal models as conveyors of senescence signals. Methods A literature search of electronic databases including MEDLINE (PubMed), Embase, ProQuest, Scopus, Google Scholar, WHO, SID, MAGIRAN, and Barakat will be conducted. Following the online search, articles will be screened by two independent reviewers according to inclusion and exclusion criteria. Eligible studies will be critically appraised by reviewers at the study level for methodological quality using Joanna Briggs Institute’s standardized critical appraisal tools. The extracted data from selected studies will cover the study populations, methods, current evidence about the physiological role of extracellular vesicles and exosomes in reproductive system, relevant outcomes, and possible conclusions about the effectiveness of exposure. Discussion Regarding the role of exosomes and their cargoes in the function of reproductive tract, the possible beneficial or adverse effects following exosomal administration from younger women to older women will be evaluated in the systematic review. As a result, exosome therapy could be suggested as a novel therapeutic agent if the favorable results are identified.https://doi.org/10.1186/s13643-019-1228-9Extracellular vesiclesExosomesmiRNAsFemale reproductionFertilityAging |
| spellingShingle | Halimeh Mobarak Reza Rahbarghazi Francesca Lolicato Mohammad Heidarpour Fariba Pashazadeh Mohammad Nouri Mahdi Mahdipour Evaluation of the association between exosomal levels and female reproductive system and fertility outcome during aging: a systematic review protocol Systematic Reviews Extracellular vesicles Exosomes miRNAs Female reproduction Fertility Aging |
| title | Evaluation of the association between exosomal levels and female reproductive system and fertility outcome during aging: a systematic review protocol |
| title_full | Evaluation of the association between exosomal levels and female reproductive system and fertility outcome during aging: a systematic review protocol |
| title_fullStr | Evaluation of the association between exosomal levels and female reproductive system and fertility outcome during aging: a systematic review protocol |
| title_full_unstemmed | Evaluation of the association between exosomal levels and female reproductive system and fertility outcome during aging: a systematic review protocol |
| title_short | Evaluation of the association between exosomal levels and female reproductive system and fertility outcome during aging: a systematic review protocol |
| title_sort | evaluation of the association between exosomal levels and female reproductive system and fertility outcome during aging a systematic review protocol |
| topic | Extracellular vesicles Exosomes miRNAs Female reproduction Fertility Aging |
| url | https://doi.org/10.1186/s13643-019-1228-9 |
| work_keys_str_mv | AT halimehmobarak evaluationoftheassociationbetweenexosomallevelsandfemalereproductivesystemandfertilityoutcomeduringagingasystematicreviewprotocol AT rezarahbarghazi evaluationoftheassociationbetweenexosomallevelsandfemalereproductivesystemandfertilityoutcomeduringagingasystematicreviewprotocol AT francescalolicato evaluationoftheassociationbetweenexosomallevelsandfemalereproductivesystemandfertilityoutcomeduringagingasystematicreviewprotocol AT mohammadheidarpour evaluationoftheassociationbetweenexosomallevelsandfemalereproductivesystemandfertilityoutcomeduringagingasystematicreviewprotocol AT faribapashazadeh evaluationoftheassociationbetweenexosomallevelsandfemalereproductivesystemandfertilityoutcomeduringagingasystematicreviewprotocol AT mohammadnouri evaluationoftheassociationbetweenexosomallevelsandfemalereproductivesystemandfertilityoutcomeduringagingasystematicreviewprotocol AT mahdimahdipour evaluationoftheassociationbetweenexosomallevelsandfemalereproductivesystemandfertilityoutcomeduringagingasystematicreviewprotocol |