Protective efficacy of selenite against lead-induced neurotoxicity in Caenorhabditis elegans.
BACKGROUND: Selenium is an essential micronutrient that has a narrow exposure window between its beneficial and toxic effects. This study investigated the protective potential of selenite (IV) against lead (Pb(II))-induced neurotoxicity in Caenorhabditis elegans. PRINCIPAL FINDINGS: The results show...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3637161?pdf=render |
| _version_ | 1818668996787961856 |
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| author | Wen-Hsuan Li Yeu-Ching Shi I-Ling Tseng Vivian Hsiu-Chuan Liao |
| author_facet | Wen-Hsuan Li Yeu-Ching Shi I-Ling Tseng Vivian Hsiu-Chuan Liao |
| author_sort | Wen-Hsuan Li |
| collection | DOAJ |
| description | BACKGROUND: Selenium is an essential micronutrient that has a narrow exposure window between its beneficial and toxic effects. This study investigated the protective potential of selenite (IV) against lead (Pb(II))-induced neurotoxicity in Caenorhabditis elegans. PRINCIPAL FINDINGS: The results showed that Se(IV) (0.01 µM) pretreatment ameliorated the decline of locomotion behaviors (frequencies of body bends, head thrashes, and reversal ) of C. elegans that are damaged by Pb(II) (100 µM) exposure. The intracellular ROS level of C. elegans induced by Pb(II) exposure was significantly lowered by Se(IV) supplementation prior to Pb(II) exposure. Finally, Se(IV) protects AFD sensory neurons from Pb(II)-induced toxicity. CONCLUSIONS: Our study suggests that Se(IV) has protective activities against Pb(II)-induced neurotoxicity through its antioxidant property. |
| first_indexed | 2024-12-17T06:45:12Z |
| format | Article |
| id | doaj.art-d4b4a047c2c64fcaafc2c2390edaaa48 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-17T06:45:12Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-d4b4a047c2c64fcaafc2c2390edaaa482022-12-21T21:59:46ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0184e6238710.1371/journal.pone.0062387Protective efficacy of selenite against lead-induced neurotoxicity in Caenorhabditis elegans.Wen-Hsuan LiYeu-Ching ShiI-Ling TsengVivian Hsiu-Chuan LiaoBACKGROUND: Selenium is an essential micronutrient that has a narrow exposure window between its beneficial and toxic effects. This study investigated the protective potential of selenite (IV) against lead (Pb(II))-induced neurotoxicity in Caenorhabditis elegans. PRINCIPAL FINDINGS: The results showed that Se(IV) (0.01 µM) pretreatment ameliorated the decline of locomotion behaviors (frequencies of body bends, head thrashes, and reversal ) of C. elegans that are damaged by Pb(II) (100 µM) exposure. The intracellular ROS level of C. elegans induced by Pb(II) exposure was significantly lowered by Se(IV) supplementation prior to Pb(II) exposure. Finally, Se(IV) protects AFD sensory neurons from Pb(II)-induced toxicity. CONCLUSIONS: Our study suggests that Se(IV) has protective activities against Pb(II)-induced neurotoxicity through its antioxidant property.http://europepmc.org/articles/PMC3637161?pdf=render |
| spellingShingle | Wen-Hsuan Li Yeu-Ching Shi I-Ling Tseng Vivian Hsiu-Chuan Liao Protective efficacy of selenite against lead-induced neurotoxicity in Caenorhabditis elegans. PLoS ONE |
| title | Protective efficacy of selenite against lead-induced neurotoxicity in Caenorhabditis elegans. |
| title_full | Protective efficacy of selenite against lead-induced neurotoxicity in Caenorhabditis elegans. |
| title_fullStr | Protective efficacy of selenite against lead-induced neurotoxicity in Caenorhabditis elegans. |
| title_full_unstemmed | Protective efficacy of selenite against lead-induced neurotoxicity in Caenorhabditis elegans. |
| title_short | Protective efficacy of selenite against lead-induced neurotoxicity in Caenorhabditis elegans. |
| title_sort | protective efficacy of selenite against lead induced neurotoxicity in caenorhabditis elegans |
| url | http://europepmc.org/articles/PMC3637161?pdf=render |
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