Association Between Polymorphism of the Angiotensin I Converting Enzyme Gene and Hypertension in Turkish Type II Diabetic Patients
It has been suggested that an insertion/deletion (I/D) polymorphism in intron 16 of the angiotensin converting enzyme (ACE) gene may be associated with essential hypertension. The aim of this study was to examine the association between ACE I/D polymorphism with blood pressure level and hypertension...
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| Format: | Article |
| Language: | English |
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Karolinum Press
2001-01-01
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| Series: | Acta Medica |
| Subjects: | |
| Online Access: | https://actamedica.lfhk.cuni.cz/44/1/0029/ |
| _version_ | 1818135204791844864 |
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| author | Mustafa Araz Sükrü Aynacioglu Sebnem Aktaran Belgin Alasehirli Vahap Okan |
| author_facet | Mustafa Araz Sükrü Aynacioglu Sebnem Aktaran Belgin Alasehirli Vahap Okan |
| author_sort | Mustafa Araz |
| collection | DOAJ |
| description | It has been suggested that an insertion/deletion (I/D) polymorphism in intron 16 of the angiotensin converting enzyme (ACE) gene may be associated with essential hypertension. The aim of this study was to examine the association between ACE I/D polymorphism with blood pressure level and hypertension status in Turkish type 2 diabetic subjects. Hundred and seven hypertensive (78 female, 29 male) and 132 normotensive type 2 diabetic subjects (73 female, 59 male) and 138 sex and age matched control subjects (87 female, 51 male) without diabetes and hypertension were included into the study. The I/D polymorphism was determined by polymerase chain reaction (PCR). There were no statistically difference in genotypic and allelic frequencies of the ACE I/D polymorphism between the hypertensive and normotensive diabetic patients and control subjects. Also no significant differences was detected in systolic and diastolic blood pressure among three different genotypes. ACE I/D polymorphism does not seem to play an important role in the development of hypertension in Turkish type 2 diabetic subjects, but prospective studies may show an association between ACE gene polymorphism and the development of hypertension in diabetic subjects. |
| first_indexed | 2024-12-11T09:20:48Z |
| format | Article |
| id | doaj.art-d4b53a849c2c4f0396f5d4fcc4d9c52c |
| institution | Directory Open Access Journal |
| issn | 1211-4286 1805-9694 |
| language | English |
| last_indexed | 2024-12-11T09:20:48Z |
| publishDate | 2001-01-01 |
| publisher | Karolinum Press |
| record_format | Article |
| series | Acta Medica |
| spelling | doaj.art-d4b53a849c2c4f0396f5d4fcc4d9c52c2022-12-22T01:13:16ZengKarolinum PressActa Medica1211-42861805-96942001-01-01441293210.14712/18059694.2019.83Association Between Polymorphism of the Angiotensin I Converting Enzyme Gene and Hypertension in Turkish Type II Diabetic PatientsMustafa Araz0Sükrü Aynacioglu1Sebnem Aktaran2Belgin Alasehirli3Vahap Okan4Gaziantep University, Medical Faculty, Department of Internal Medicine, Gaziantep, TurkeyGaziantep University, Medical Faculty, Department of Pharmacology, Gaziantep, TurkeyGaziantep University, Medical Faculty, Department of Internal Medicine, Gaziantep, TurkeyGaziantep University, Medical Faculty, Department of Pharmacology, Gaziantep, TurkeyGaziantep University, Medical Faculty, Department of Internal Medicine, Gaziantep, TurkeyIt has been suggested that an insertion/deletion (I/D) polymorphism in intron 16 of the angiotensin converting enzyme (ACE) gene may be associated with essential hypertension. The aim of this study was to examine the association between ACE I/D polymorphism with blood pressure level and hypertension status in Turkish type 2 diabetic subjects. Hundred and seven hypertensive (78 female, 29 male) and 132 normotensive type 2 diabetic subjects (73 female, 59 male) and 138 sex and age matched control subjects (87 female, 51 male) without diabetes and hypertension were included into the study. The I/D polymorphism was determined by polymerase chain reaction (PCR). There were no statistically difference in genotypic and allelic frequencies of the ACE I/D polymorphism between the hypertensive and normotensive diabetic patients and control subjects. Also no significant differences was detected in systolic and diastolic blood pressure among three different genotypes. ACE I/D polymorphism does not seem to play an important role in the development of hypertension in Turkish type 2 diabetic subjects, but prospective studies may show an association between ACE gene polymorphism and the development of hypertension in diabetic subjects.https://actamedica.lfhk.cuni.cz/44/1/0029/Angiotensin converting enzymePolymorphismType 2 diabetes mellitus and essential hypertension |
| spellingShingle | Mustafa Araz Sükrü Aynacioglu Sebnem Aktaran Belgin Alasehirli Vahap Okan Association Between Polymorphism of the Angiotensin I Converting Enzyme Gene and Hypertension in Turkish Type II Diabetic Patients Acta Medica Angiotensin converting enzyme Polymorphism Type 2 diabetes mellitus and essential hypertension |
| title | Association Between Polymorphism of the Angiotensin I Converting Enzyme Gene and Hypertension in Turkish Type II Diabetic Patients |
| title_full | Association Between Polymorphism of the Angiotensin I Converting Enzyme Gene and Hypertension in Turkish Type II Diabetic Patients |
| title_fullStr | Association Between Polymorphism of the Angiotensin I Converting Enzyme Gene and Hypertension in Turkish Type II Diabetic Patients |
| title_full_unstemmed | Association Between Polymorphism of the Angiotensin I Converting Enzyme Gene and Hypertension in Turkish Type II Diabetic Patients |
| title_short | Association Between Polymorphism of the Angiotensin I Converting Enzyme Gene and Hypertension in Turkish Type II Diabetic Patients |
| title_sort | association between polymorphism of the angiotensin i converting enzyme gene and hypertension in turkish type ii diabetic patients |
| topic | Angiotensin converting enzyme Polymorphism Type 2 diabetes mellitus and essential hypertension |
| url | https://actamedica.lfhk.cuni.cz/44/1/0029/ |
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