The Avon Longitudinal Study of Parents and Children - A resource for COVID-19 research: Antibody testing results, April – June 2021 [version 2; peer review: 2 approved]
The Avon Longitudinal Study of Parents and Children (ALSPAC) is a prospective population-based cohort which recruited pregnant women in 1990-1992 and has followed these women, their partners (Generation 0; G0) and their offspring (Generation 1; G1) ever since. The study reacted rapidly and repeatedl...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wellcome
2022-01-01
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| Series: | Wellcome Open Research |
| Subjects: | |
| Online Access: | https://wellcomeopenresearch.org/articles/6-283/v2 |
| _version_ | 1828489030622248960 |
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| author | Nicholas Wells Sarah Matthews Hannah Woodward Kate Northstone Thomas Breeze Lynn Molloy Nicholas John Timpson Michael Crawford Daniel Major-Smith Ruth Mitchell |
| author_facet | Nicholas Wells Sarah Matthews Hannah Woodward Kate Northstone Thomas Breeze Lynn Molloy Nicholas John Timpson Michael Crawford Daniel Major-Smith Ruth Mitchell |
| author_sort | Nicholas Wells |
| collection | DOAJ |
| description | The Avon Longitudinal Study of Parents and Children (ALSPAC) is a prospective population-based cohort which recruited pregnant women in 1990-1992 and has followed these women, their partners (Generation 0; G0) and their offspring (Generation 1; G1) ever since. The study reacted rapidly and repeatedly to the coronavirus disease 2019 (COVID-19) pandemic, deploying multiple online questionnaires and a previous home-based antibody test in October 2020. A second antibody test, in collaboration with ten other longitudinal population studies, was completed by 4,622 ALSPAC participants between April and June 2021. Of 4,241 participants with a valid spike protein antibody test result (8.2% were void), indicating antibody response to either COVID-19 vaccination or natural infection, 3,172 were positive (74.8%). Generational differences were substantial, with 2,463/2,555 G0 participants classified positive (96.4%) compared to 709/1,686 G1 participants (42.1%). Of 4,199 participants with a valid nucleocapsid antibody test result (9.2% were void), suggesting potential and recent natural infection, 493 were positive (11.7%); 248/2,526 G0 participants (9.8%) and 245/1,673 G1 participants (14.6%) tested positive, respectively. We also compare results for this round of testing to that undertaken in October 2020. Future work will combine these test results with additional sources of data to identify participants’ COVID-19 infection and vaccination status. These ALSPAC COVID-19 serology data are being complemented with linkage to health records and Public Health England pillar testing results as they become available, in addition to four previous questionnaire waves and a prior antibody test. Data have been released as an update to the previous COVID-19 datasets. These comprise: 1) a standard dataset containing all participant responses to all four previous questionnaires with key sociodemographic factors; and 2) individual participant-specific release files enabling bespoke research across all areas supported by the study. This data note describes the second ALSPAC antibody test and the data obtained from it. |
| first_indexed | 2024-12-11T10:19:03Z |
| format | Article |
| id | doaj.art-d4b56bacddcf43b78eac70574e996ef9 |
| institution | Directory Open Access Journal |
| issn | 2398-502X |
| language | English |
| last_indexed | 2024-12-11T10:19:03Z |
| publishDate | 2022-01-01 |
| publisher | Wellcome |
| record_format | Article |
| series | Wellcome Open Research |
| spelling | doaj.art-d4b56bacddcf43b78eac70574e996ef92022-12-22T01:11:32ZengWellcomeWellcome Open Research2398-502X2022-01-01619485The Avon Longitudinal Study of Parents and Children - A resource for COVID-19 research: Antibody testing results, April – June 2021 [version 2; peer review: 2 approved]Nicholas Wells0Sarah Matthews1Hannah Woodward2Kate Northstone3https://orcid.org/0000-0002-0602-1983Thomas Breeze4Lynn Molloy5Nicholas John Timpson6https://orcid.org/0000-0002-7141-9189Michael Crawford7Daniel Major-Smith8https://orcid.org/0000-0001-6467-2023Ruth Mitchell9https://orcid.org/0000-0002-3506-160XPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UKPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UKPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UKPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UKPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UKPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UKPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UKPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UKPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UKMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UKThe Avon Longitudinal Study of Parents and Children (ALSPAC) is a prospective population-based cohort which recruited pregnant women in 1990-1992 and has followed these women, their partners (Generation 0; G0) and their offspring (Generation 1; G1) ever since. The study reacted rapidly and repeatedly to the coronavirus disease 2019 (COVID-19) pandemic, deploying multiple online questionnaires and a previous home-based antibody test in October 2020. A second antibody test, in collaboration with ten other longitudinal population studies, was completed by 4,622 ALSPAC participants between April and June 2021. Of 4,241 participants with a valid spike protein antibody test result (8.2% were void), indicating antibody response to either COVID-19 vaccination or natural infection, 3,172 were positive (74.8%). Generational differences were substantial, with 2,463/2,555 G0 participants classified positive (96.4%) compared to 709/1,686 G1 participants (42.1%). Of 4,199 participants with a valid nucleocapsid antibody test result (9.2% were void), suggesting potential and recent natural infection, 493 were positive (11.7%); 248/2,526 G0 participants (9.8%) and 245/1,673 G1 participants (14.6%) tested positive, respectively. We also compare results for this round of testing to that undertaken in October 2020. Future work will combine these test results with additional sources of data to identify participants’ COVID-19 infection and vaccination status. These ALSPAC COVID-19 serology data are being complemented with linkage to health records and Public Health England pillar testing results as they become available, in addition to four previous questionnaire waves and a prior antibody test. Data have been released as an update to the previous COVID-19 datasets. These comprise: 1) a standard dataset containing all participant responses to all four previous questionnaires with key sociodemographic factors; and 2) individual participant-specific release files enabling bespoke research across all areas supported by the study. This data note describes the second ALSPAC antibody test and the data obtained from it.https://wellcomeopenresearch.org/articles/6-283/v2ALSPAC Children of the 90s birth cohort study COVID-19 coronavirus antibody testingeng |
| spellingShingle | Nicholas Wells Sarah Matthews Hannah Woodward Kate Northstone Thomas Breeze Lynn Molloy Nicholas John Timpson Michael Crawford Daniel Major-Smith Ruth Mitchell The Avon Longitudinal Study of Parents and Children - A resource for COVID-19 research: Antibody testing results, April – June 2021 [version 2; peer review: 2 approved] Wellcome Open Research ALSPAC Children of the 90s birth cohort study COVID-19 coronavirus antibody testing eng |
| title | The Avon Longitudinal Study of Parents and Children - A resource for COVID-19 research: Antibody testing results, April – June 2021 [version 2; peer review: 2 approved] |
| title_full | The Avon Longitudinal Study of Parents and Children - A resource for COVID-19 research: Antibody testing results, April – June 2021 [version 2; peer review: 2 approved] |
| title_fullStr | The Avon Longitudinal Study of Parents and Children - A resource for COVID-19 research: Antibody testing results, April – June 2021 [version 2; peer review: 2 approved] |
| title_full_unstemmed | The Avon Longitudinal Study of Parents and Children - A resource for COVID-19 research: Antibody testing results, April – June 2021 [version 2; peer review: 2 approved] |
| title_short | The Avon Longitudinal Study of Parents and Children - A resource for COVID-19 research: Antibody testing results, April – June 2021 [version 2; peer review: 2 approved] |
| title_sort | avon longitudinal study of parents and children a resource for covid 19 research antibody testing results april june 2021 version 2 peer review 2 approved |
| topic | ALSPAC Children of the 90s birth cohort study COVID-19 coronavirus antibody testing eng |
| url | https://wellcomeopenresearch.org/articles/6-283/v2 |
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