Low KIBRA Expression Is Associated with Poor Prognosis in Patients with Triple-Negative Breast Cancer
<i>Background and Objectives</i>: Kidney and brain protein (KIBRA) is a protein encoded by the WW and C2 domain containing 1 (<i>WWC1</i>) gene and is involved in the Hippo signaling pathway. Recent studies have revealed the prognostic value of KIBRA expression; however, its...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/57/8/837 |
| _version_ | 1797523020822085632 |
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| author | So-Woon Kim Jinah Chu Sung-Im Do Kiyong Na |
| author_facet | So-Woon Kim Jinah Chu Sung-Im Do Kiyong Na |
| author_sort | So-Woon Kim |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Kidney and brain protein (KIBRA) is a protein encoded by the WW and C2 domain containing 1 (<i>WWC1</i>) gene and is involved in the Hippo signaling pathway. Recent studies have revealed the prognostic value of KIBRA expression; however, its role in breast cancer remains unclear. The aim of this study was to examine KIBRA expression in relation to the clinical and pathological characteristics of patients with breast cancer and to disease outcomes. <i>Materials and Methods:</i> We analyzed the expression of KIBRA and its correlation with event-free survival (EFS) outcomes in resected samples from 486 patients with breast cancer. <i>Results:</i> KIBRA expression was significantly different among the molecular subgroups (low KIBRA expression: luminal A, 46.7% versus 50.0%, <i>p</i> = 0.641; luminal B, 32.7% versus 71.7%, <i>p</i> < 0.001; human epidermal growth factor receptor 2 (HER2)-enriched, 64.9% versus 45.5%. <i>p</i> = 0.001; triple-negative, 73.6% versus 43.8%, <i>p</i> < 0.001). Low KIBRA expression was also associated with high nuclear grade (60.4% versus 37.8%, <i>p</i> < 0.001), high histologic grade (58.7% versus 37.0%, <i>p</i> < 0.001), and estrogen receptor (ER) negativity (54.2% versus 23.6%, <i>p</i> < 0.001). Low KIBRA expression was significantly associated with poor EFS (<i>p</i> = 0.041; hazard ratio (HR) 1.658; 95% confidence interval (CI), 1.015–2.709). Low KIBRA expression was an independent indicator of poor prognosis (<i>p</i> = 0.001; HR = 3.952; 95% CI = 1.542–10.133) in triple-negative breast cancer (TNBC). <i>Conclusion:</i> Low KIBRA expression was associated with higher histological grade, ER negativity and poor EFS of breast cancer. In particular, our data highlight KIBRA expression status as a potential prognostic marker for TNBC. |
| first_indexed | 2024-03-10T08:37:31Z |
| format | Article |
| id | doaj.art-d4b6b42be92c4cfb9361ca6095b68b38 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-10T08:37:31Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
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| series | Medicina |
| spelling | doaj.art-d4b6b42be92c4cfb9361ca6095b68b382023-11-22T08:36:51ZengMDPI AGMedicina1010-660X1648-91442021-08-0157883710.3390/medicina57080837Low KIBRA Expression Is Associated with Poor Prognosis in Patients with Triple-Negative Breast CancerSo-Woon Kim0Jinah Chu1Sung-Im Do2Kiyong Na3Department of Pathology, Kyung Hee University Hospital, Kyung Hee University College of Medicine, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, KoreaDepartment of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul 03181, KoreaDepartment of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul 03181, KoreaDepartment of Pathology, Kyung Hee University Hospital, Kyung Hee University College of Medicine, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea<i>Background and Objectives</i>: Kidney and brain protein (KIBRA) is a protein encoded by the WW and C2 domain containing 1 (<i>WWC1</i>) gene and is involved in the Hippo signaling pathway. Recent studies have revealed the prognostic value of KIBRA expression; however, its role in breast cancer remains unclear. The aim of this study was to examine KIBRA expression in relation to the clinical and pathological characteristics of patients with breast cancer and to disease outcomes. <i>Materials and Methods:</i> We analyzed the expression of KIBRA and its correlation with event-free survival (EFS) outcomes in resected samples from 486 patients with breast cancer. <i>Results:</i> KIBRA expression was significantly different among the molecular subgroups (low KIBRA expression: luminal A, 46.7% versus 50.0%, <i>p</i> = 0.641; luminal B, 32.7% versus 71.7%, <i>p</i> < 0.001; human epidermal growth factor receptor 2 (HER2)-enriched, 64.9% versus 45.5%. <i>p</i> = 0.001; triple-negative, 73.6% versus 43.8%, <i>p</i> < 0.001). Low KIBRA expression was also associated with high nuclear grade (60.4% versus 37.8%, <i>p</i> < 0.001), high histologic grade (58.7% versus 37.0%, <i>p</i> < 0.001), and estrogen receptor (ER) negativity (54.2% versus 23.6%, <i>p</i> < 0.001). Low KIBRA expression was significantly associated with poor EFS (<i>p</i> = 0.041; hazard ratio (HR) 1.658; 95% confidence interval (CI), 1.015–2.709). Low KIBRA expression was an independent indicator of poor prognosis (<i>p</i> = 0.001; HR = 3.952; 95% CI = 1.542–10.133) in triple-negative breast cancer (TNBC). <i>Conclusion:</i> Low KIBRA expression was associated with higher histological grade, ER negativity and poor EFS of breast cancer. In particular, our data highlight KIBRA expression status as a potential prognostic marker for TNBC.https://www.mdpi.com/1648-9144/57/8/837KIBRAbreast cancertriple-negative breast cancerHippo pathway |
| spellingShingle | So-Woon Kim Jinah Chu Sung-Im Do Kiyong Na Low KIBRA Expression Is Associated with Poor Prognosis in Patients with Triple-Negative Breast Cancer Medicina KIBRA breast cancer triple-negative breast cancer Hippo pathway |
| title | Low KIBRA Expression Is Associated with Poor Prognosis in Patients with Triple-Negative Breast Cancer |
| title_full | Low KIBRA Expression Is Associated with Poor Prognosis in Patients with Triple-Negative Breast Cancer |
| title_fullStr | Low KIBRA Expression Is Associated with Poor Prognosis in Patients with Triple-Negative Breast Cancer |
| title_full_unstemmed | Low KIBRA Expression Is Associated with Poor Prognosis in Patients with Triple-Negative Breast Cancer |
| title_short | Low KIBRA Expression Is Associated with Poor Prognosis in Patients with Triple-Negative Breast Cancer |
| title_sort | low kibra expression is associated with poor prognosis in patients with triple negative breast cancer |
| topic | KIBRA breast cancer triple-negative breast cancer Hippo pathway |
| url | https://www.mdpi.com/1648-9144/57/8/837 |
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