Genetic basis of the resistance to Strongyloides venezuelensis (Nematoda, Rhabdiasidae) infection in mice (Mus musculus)
We investigated the resistance to Strongyloides venezuelensis primary infection of mice strains NIH (resistant) and C57BL/6 (susceptible) and the F1 and F2 offspring of crosses between these strains. The mice were infected with 2000 larvae and seven days later were sacrificed for parasite recovery a...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Genética
2007-01-01
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| Series: | Genetics and Molecular Biology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000100012 |
| _version_ | 1828522609553178624 |
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| author | Nelson Mendes Marra Alessandro F.T. Amarante Mônica R.V. Amarante |
| author_facet | Nelson Mendes Marra Alessandro F.T. Amarante Mônica R.V. Amarante |
| author_sort | Nelson Mendes Marra |
| collection | DOAJ |
| description | We investigated the resistance to Strongyloides venezuelensis primary infection of mice strains NIH (resistant) and C57BL/6 (susceptible) and the F1 and F2 offspring of crosses between these strains. The mice were infected with 2000 larvae and seven days later were sacrificed for parasite recovery and counting. There was no statistically significant (p > 0.05) sex effect on resistance. The F1 mice showed an intermediate mean number of parasites as compared to the parental NIH and C57BL6 strains. Out of 400 F2 mice, the 10% most resistant mice were infected with 21 to 97 parasites, while the 10% most susceptible mice were infected with 1027 to 1433 parasites. We also found that F2 mice with black fur (n = 72), the same color as the C57BL/6 susceptible parental strain, were more susceptible than white (n = 104) or gray furred (n = 224) mice. It is conceivable that some genes determining coat color are located on the same chromosome as where genes controlling helminth resistance. |
| first_indexed | 2024-12-11T20:12:09Z |
| format | Article |
| id | doaj.art-d4b738409b8543b795b6245415e09a3a |
| institution | Directory Open Access Journal |
| issn | 1415-4757 1678-4685 |
| language | English |
| last_indexed | 2024-12-11T20:12:09Z |
| publishDate | 2007-01-01 |
| publisher | Sociedade Brasileira de Genética |
| record_format | Article |
| series | Genetics and Molecular Biology |
| spelling | doaj.art-d4b738409b8543b795b6245415e09a3a2022-12-22T00:52:17ZengSociedade Brasileira de GenéticaGenetics and Molecular Biology1415-47571678-46852007-01-01301606410.1590/S1415-47572007000100012Genetic basis of the resistance to Strongyloides venezuelensis (Nematoda, Rhabdiasidae) infection in mice (Mus musculus)Nelson Mendes MarraAlessandro F.T. AmaranteMônica R.V. AmaranteWe investigated the resistance to Strongyloides venezuelensis primary infection of mice strains NIH (resistant) and C57BL/6 (susceptible) and the F1 and F2 offspring of crosses between these strains. The mice were infected with 2000 larvae and seven days later were sacrificed for parasite recovery and counting. There was no statistically significant (p > 0.05) sex effect on resistance. The F1 mice showed an intermediate mean number of parasites as compared to the parental NIH and C57BL6 strains. Out of 400 F2 mice, the 10% most resistant mice were infected with 21 to 97 parasites, while the 10% most susceptible mice were infected with 1027 to 1433 parasites. We also found that F2 mice with black fur (n = 72), the same color as the C57BL/6 susceptible parental strain, were more susceptible than white (n = 104) or gray furred (n = 224) mice. It is conceivable that some genes determining coat color are located on the same chromosome as where genes controlling helminth resistance.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000100012miceStrongyloides venezuelensisresistancegenetics |
| spellingShingle | Nelson Mendes Marra Alessandro F.T. Amarante Mônica R.V. Amarante Genetic basis of the resistance to Strongyloides venezuelensis (Nematoda, Rhabdiasidae) infection in mice (Mus musculus) Genetics and Molecular Biology mice Strongyloides venezuelensis resistance genetics |
| title | Genetic basis of the resistance to Strongyloides venezuelensis (Nematoda, Rhabdiasidae) infection in mice (Mus musculus) |
| title_full | Genetic basis of the resistance to Strongyloides venezuelensis (Nematoda, Rhabdiasidae) infection in mice (Mus musculus) |
| title_fullStr | Genetic basis of the resistance to Strongyloides venezuelensis (Nematoda, Rhabdiasidae) infection in mice (Mus musculus) |
| title_full_unstemmed | Genetic basis of the resistance to Strongyloides venezuelensis (Nematoda, Rhabdiasidae) infection in mice (Mus musculus) |
| title_short | Genetic basis of the resistance to Strongyloides venezuelensis (Nematoda, Rhabdiasidae) infection in mice (Mus musculus) |
| title_sort | genetic basis of the resistance to strongyloides venezuelensis nematoda rhabdiasidae infection in mice mus musculus |
| topic | mice Strongyloides venezuelensis resistance genetics |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000100012 |
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