Posterior Spinal Correction and Fusion Surgery in Patients with Spinal Muscular Atrophy-Associated Scoliosis for Whom Treatment with Nusinersen Was Planned
Introduction: Spinal muscular atrophy (SMA) is defined as a neuromuscular disorder induced by progressive weakness of the skeletal muscle and is usually accompanied by progressive spinal deformity including scoliosis. The newly developed Nusinersen, which is the first approved drug worldwide for SMA...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
The Japanese Society for Spine Surgery and Related Research
2021-03-01
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| Series: | Spine Surgery and Related Research |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/ssrr/5/2/5_2020-0091/_pdf/-char/en |
| _version_ | 1818603351897538560 |
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| author | Shuhei Machida Masayuki Miyagi Wataru Saito Ayano Matsui Takayuki Imura Gen Inoue Toshiyuki Nakazawa Eiki Shirasawa Shinsuke Ikeda Ayumu Kawakubo Akiyoshi Kuroda Yuji Yokozeki Yusuke Mimura Kentaro Uchida Tsutomu Akazawa Masashi Takaso |
| author_facet | Shuhei Machida Masayuki Miyagi Wataru Saito Ayano Matsui Takayuki Imura Gen Inoue Toshiyuki Nakazawa Eiki Shirasawa Shinsuke Ikeda Ayumu Kawakubo Akiyoshi Kuroda Yuji Yokozeki Yusuke Mimura Kentaro Uchida Tsutomu Akazawa Masashi Takaso |
| author_sort | Shuhei Machida |
| collection | DOAJ |
| description | Introduction: Spinal muscular atrophy (SMA) is defined as a neuromuscular disorder induced by progressive weakness of the skeletal muscle and is usually accompanied by progressive spinal deformity including scoliosis. The newly developed Nusinersen, which is the first approved drug worldwide for SMA, requires accurate intrathecal injection, which is sometimes difficult in patients with severe spinal deformity.
Technical Note: For an accurate intrathecal approach in patients who have spinal fusion surgery to treat neuromuscular scoliosis, we have combined an L3 laminectomy with spinal correction and fusion surgery. Here, we review four cases of SMA in patients who underwent the additional L3 laminectomy during surgery to treat spinal scoliosis. A successful intrathecal approach was made using fluoroscopic guidance in all four patients, who were then administered with Nusinersen.
Conclusions: Our findings show that additional lumbar laminectomy during surgery for spinal scoliosis has effectively allowed for intrathecal injection of Nusinersen. |
| first_indexed | 2024-12-16T13:21:48Z |
| format | Article |
| id | doaj.art-d4b748edc0e2459c9001b27126572b14 |
| institution | Directory Open Access Journal |
| issn | 2432-261X |
| language | English |
| last_indexed | 2024-12-16T13:21:48Z |
| publishDate | 2021-03-01 |
| publisher | The Japanese Society for Spine Surgery and Related Research |
| record_format | Article |
| series | Spine Surgery and Related Research |
| spelling | doaj.art-d4b748edc0e2459c9001b27126572b142022-12-21T22:30:19ZengThe Japanese Society for Spine Surgery and Related ResearchSpine Surgery and Related Research2432-261X2021-03-015210911310.22603/ssrr.2020-00912020-0091Posterior Spinal Correction and Fusion Surgery in Patients with Spinal Muscular Atrophy-Associated Scoliosis for Whom Treatment with Nusinersen Was PlannedShuhei Machida0Masayuki Miyagi1Wataru Saito2Ayano Matsui3Takayuki Imura4Gen Inoue5Toshiyuki Nakazawa6Eiki Shirasawa7Shinsuke Ikeda8Ayumu Kawakubo9Akiyoshi Kuroda10Yuji Yokozeki11Yusuke Mimura12Kentaro Uchida13Tsutomu Akazawa14Masashi Takaso15Department of Orthopaedic Surgery, School of Medicine, Kitasato UniversityDepartment of Orthopaedic Surgery, School of Medicine, Kitasato UniversityDepartment of Orthopaedic Surgery, School of Medicine, Kitasato UniversityDepartment of Orthopaedic Surgery, National Center of Neurology and PsychiatryDepartment of Orthopaedic Surgery, School of Medicine, Kitasato UniversityDepartment of Orthopaedic Surgery, School of Medicine, Kitasato UniversityDepartment of Orthopaedic Surgery, School of Medicine, Kitasato UniversityDepartment of Orthopaedic Surgery, School of Medicine, Kitasato UniversityDepartment of Orthopaedic Surgery, School of Medicine, Kitasato UniversityDepartment of Orthopaedic Surgery, School of Medicine, Kitasato UniversityDepartment of Orthopaedic Surgery, School of Medicine, Kitasato UniversityDepartment of Orthopaedic Surgery, School of Medicine, Kitasato UniversityDepartment of Orthopaedic Surgery, School of Medicine, Kitasato UniversityDepartment of Orthopaedic Surgery, School of Medicine, Kitasato UniversityDepartment of Orthopaedic Surgery, School of Medicine, Kitasato UniversityDepartment of Orthopaedic Surgery, School of Medicine, Kitasato UniversityIntroduction: Spinal muscular atrophy (SMA) is defined as a neuromuscular disorder induced by progressive weakness of the skeletal muscle and is usually accompanied by progressive spinal deformity including scoliosis. The newly developed Nusinersen, which is the first approved drug worldwide for SMA, requires accurate intrathecal injection, which is sometimes difficult in patients with severe spinal deformity. Technical Note: For an accurate intrathecal approach in patients who have spinal fusion surgery to treat neuromuscular scoliosis, we have combined an L3 laminectomy with spinal correction and fusion surgery. Here, we review four cases of SMA in patients who underwent the additional L3 laminectomy during surgery to treat spinal scoliosis. A successful intrathecal approach was made using fluoroscopic guidance in all four patients, who were then administered with Nusinersen. Conclusions: Our findings show that additional lumbar laminectomy during surgery for spinal scoliosis has effectively allowed for intrathecal injection of Nusinersen.https://www.jstage.jst.go.jp/article/ssrr/5/2/5_2020-0091/_pdf/-char/enneuromuscular scoliosisspinal muscular atrophynusinersen |
| spellingShingle | Shuhei Machida Masayuki Miyagi Wataru Saito Ayano Matsui Takayuki Imura Gen Inoue Toshiyuki Nakazawa Eiki Shirasawa Shinsuke Ikeda Ayumu Kawakubo Akiyoshi Kuroda Yuji Yokozeki Yusuke Mimura Kentaro Uchida Tsutomu Akazawa Masashi Takaso Posterior Spinal Correction and Fusion Surgery in Patients with Spinal Muscular Atrophy-Associated Scoliosis for Whom Treatment with Nusinersen Was Planned Spine Surgery and Related Research neuromuscular scoliosis spinal muscular atrophy nusinersen |
| title | Posterior Spinal Correction and Fusion Surgery in Patients with Spinal Muscular Atrophy-Associated Scoliosis for Whom Treatment with Nusinersen Was Planned |
| title_full | Posterior Spinal Correction and Fusion Surgery in Patients with Spinal Muscular Atrophy-Associated Scoliosis for Whom Treatment with Nusinersen Was Planned |
| title_fullStr | Posterior Spinal Correction and Fusion Surgery in Patients with Spinal Muscular Atrophy-Associated Scoliosis for Whom Treatment with Nusinersen Was Planned |
| title_full_unstemmed | Posterior Spinal Correction and Fusion Surgery in Patients with Spinal Muscular Atrophy-Associated Scoliosis for Whom Treatment with Nusinersen Was Planned |
| title_short | Posterior Spinal Correction and Fusion Surgery in Patients with Spinal Muscular Atrophy-Associated Scoliosis for Whom Treatment with Nusinersen Was Planned |
| title_sort | posterior spinal correction and fusion surgery in patients with spinal muscular atrophy associated scoliosis for whom treatment with nusinersen was planned |
| topic | neuromuscular scoliosis spinal muscular atrophy nusinersen |
| url | https://www.jstage.jst.go.jp/article/ssrr/5/2/5_2020-0091/_pdf/-char/en |
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