Hydrogel Development for Rotator Cuff Repair
Rotator cuff tears (RCTs) are common in shoulder disease and disability. Despite significant advances in surgical repair techniques, 20–70% of patients still have postoperative rotator cuff dysfunction. These functional defects may be related to retear or rotator cuff quality deterioration due to te...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.851660/full |
| _version_ | 1818546331072856064 |
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| author | Zhengyu Xu Yifei Fang Yao Chen Yushuang Zhao Wei Wei Wei Wei Chong Teng |
| author_facet | Zhengyu Xu Yifei Fang Yao Chen Yushuang Zhao Wei Wei Wei Wei Chong Teng |
| author_sort | Zhengyu Xu |
| collection | DOAJ |
| description | Rotator cuff tears (RCTs) are common in shoulder disease and disability. Despite significant advances in surgical repair techniques, 20–70% of patients still have postoperative rotator cuff dysfunction. These functional defects may be related to retear or rotator cuff quality deterioration due to tendon retraction and scar tissue at the repair site. As an effective delivery system, hydrogel scaffolds may improve the healing of RCTs and be a useful treatment for irreparable rotator cuff injuries. Although many studies have tested this hypothesis, most are limited to laboratory animal experiments. This review summarizes differences in hydrogel scaffold construction, active ingredients, and application methods in recent research. Efforts to determine the indications of hydrogel scaffolds (with different constructions and cargos) for various types of RCTs, as well as the effectiveness and reliability of application methods and devices, are also discussed. |
| first_indexed | 2024-12-12T07:51:46Z |
| format | Article |
| id | doaj.art-d4b74b5a3bd14274bde2a8b17d1b09ac |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-12T07:51:46Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-d4b74b5a3bd14274bde2a8b17d1b09ac2022-12-22T00:32:25ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-06-011010.3389/fbioe.2022.851660851660Hydrogel Development for Rotator Cuff RepairZhengyu Xu0Yifei Fang1Yao Chen2Yushuang Zhao3Wei Wei4Wei Wei5Chong Teng6Department of Orthopaedics, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, ChinaDepartment of Orthopaedics, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, ChinaDepartment of Orthopaedics, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, ChinaDepartment of Orthopaedics, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, ChinaDepartment of Orthopaedics, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, ChinaKey Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province, Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Orthopaedics, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, ChinaRotator cuff tears (RCTs) are common in shoulder disease and disability. Despite significant advances in surgical repair techniques, 20–70% of patients still have postoperative rotator cuff dysfunction. These functional defects may be related to retear or rotator cuff quality deterioration due to tendon retraction and scar tissue at the repair site. As an effective delivery system, hydrogel scaffolds may improve the healing of RCTs and be a useful treatment for irreparable rotator cuff injuries. Although many studies have tested this hypothesis, most are limited to laboratory animal experiments. This review summarizes differences in hydrogel scaffold construction, active ingredients, and application methods in recent research. Efforts to determine the indications of hydrogel scaffolds (with different constructions and cargos) for various types of RCTs, as well as the effectiveness and reliability of application methods and devices, are also discussed.https://www.frontiersin.org/articles/10.3389/fbioe.2022.851660/fullhydrogelrotator cufftissue engineeringregeneration medicinecytokine |
| spellingShingle | Zhengyu Xu Yifei Fang Yao Chen Yushuang Zhao Wei Wei Wei Wei Chong Teng Hydrogel Development for Rotator Cuff Repair Frontiers in Bioengineering and Biotechnology hydrogel rotator cuff tissue engineering regeneration medicine cytokine |
| title | Hydrogel Development for Rotator Cuff Repair |
| title_full | Hydrogel Development for Rotator Cuff Repair |
| title_fullStr | Hydrogel Development for Rotator Cuff Repair |
| title_full_unstemmed | Hydrogel Development for Rotator Cuff Repair |
| title_short | Hydrogel Development for Rotator Cuff Repair |
| title_sort | hydrogel development for rotator cuff repair |
| topic | hydrogel rotator cuff tissue engineering regeneration medicine cytokine |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.851660/full |
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