Kinome-Wide Screening with Small Interfering RNA Identified Polo-like Kinase 1 as a Key Regulator of Proliferation in Oral Cancer Cells

Kinome-Wide Screening with Small Interfering RNA Identified Polo-like Kinase 1 as a Key Regulator of Proliferation in Oral Cancer Cells

Oral squamous cell carcinoma (OSCC) is one of the major leading causes of cancer-related death worldwide, with limited effective markers for diagnosis and therapy, which has caused a low overall survival rate in the past decades. Kinases play important roles in tumor development and malignancy in va...

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Bibliographic Details
Main Authors: Yih-Gang Goan, Pei-Feng Liu, Hsueh-Wei Chang, Hung-Chih Chen, Wen-Chi Chen, Shyh-Ming Kuo, Cheng-Hsin Lee, Chih-Wen Shu
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Cancers
Subjects:
kinome
siRNA screening
<i>PLK1</i>
oral squamous cell carcinoma
prognosis
biomarker
Online Access:https://www.mdpi.com/2072-6694/11/8/1117

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