Possible association of fimA genotype of Porphyromonas gulae with the severity of periodontal disease and the number of permanent teeth in dogs
Previous research has demonstrated that Porphyromonas gulae (P. gulae) significantly contributes to the development of periodontal disease in dogs. Porphyromonas gulae is divided into three subtypes according to the 41-kDa filamentous appendage (fimA), defined as types A, B, and C. This study aimed...
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| Format: | Article |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2023.1022838/full |
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| author | So Shirahata So Shirahata Naoki Iwashita Naoki Iwashita Rie Sasaki Ryota Nomura Masaru Murakami Junya Yasuda Hidemi Yasuda Kuniyasu Nakajima Hiroaki Inaba Michiyo Matsumoto-Nakano Kazuhiko Nakano Jumpei Uchiyama Tomoki Fukuyama |
| author_facet | So Shirahata So Shirahata Naoki Iwashita Naoki Iwashita Rie Sasaki Ryota Nomura Masaru Murakami Junya Yasuda Hidemi Yasuda Kuniyasu Nakajima Hiroaki Inaba Michiyo Matsumoto-Nakano Kazuhiko Nakano Jumpei Uchiyama Tomoki Fukuyama |
| author_sort | So Shirahata |
| collection | DOAJ |
| description | Previous research has demonstrated that Porphyromonas gulae (P. gulae) significantly contributes to the development of periodontal disease in dogs. Porphyromonas gulae is divided into three subtypes according to the 41-kDa filamentous appendage (fimA), defined as types A, B, and C. This study aimed to elucidate the association between fimA type of P. gulae with the number of permanent teeth, reflecting the severity of periodontal disease. Two hundred twenty-five dogs were categorized by P. gulae fimA type as negative, type A dominant, type B dominant, and type C dominant. The stage of periodontal disease in P. gulae-positive dogs increased with age, particularly in type C dominant dogs. Correspondingly, the number of permanent teeth in P. gulae fimA type C-dominant dogs was significantly lower than that of P. gulae-negative dogs, suggesting there is a significant association between fimA type of P. gulae and the number of permanent teeth resulting from the development of periodontal disease. |
| first_indexed | 2024-04-10T17:05:38Z |
| format | Article |
| id | doaj.art-d4b9a55a11ee430094c84d7fa7594916 |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-04-10T17:05:38Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-d4b9a55a11ee430094c84d7fa75949162023-02-06T05:37:13ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692023-02-011010.3389/fvets.2023.10228381022838Possible association of fimA genotype of Porphyromonas gulae with the severity of periodontal disease and the number of permanent teeth in dogsSo Shirahata0So Shirahata1Naoki Iwashita2Naoki Iwashita3Rie Sasaki4Ryota Nomura5Masaru Murakami6Junya Yasuda7Hidemi Yasuda8Kuniyasu Nakajima9Hiroaki Inaba10Michiyo Matsumoto-Nakano11Kazuhiko Nakano12Jumpei Uchiyama13Tomoki Fukuyama14Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa, JapanPrimo Animal Hospital Sagamiharachuo, Sagamihara, Kanagawa, JapanLaboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa, JapanBioalchemis, Fuchu, Tokyo, JapanLaboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa, JapanDepartment of Pediatric Dentistry, Osaka University Graduate School of Dentistry, Suita, Osaka, JapanLaboratory of Molecular Biology, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa, JapanSPECTRUM LAB. JAPAN Co., LTD., Yasuda Veterinary Clinic, Tokyo, JapanAlphaVets Co., LTD., Yasuda Veterinary Clinic, Tokyo, JapanNakajima Animal Hospital, Tokyo, JapanDepartment of Pediatric Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, JapanDepartment of Pediatric Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, JapanDepartment of Pediatric Dentistry, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan0Department of Bacteriology, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Okayama, JapanLaboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa, JapanPrevious research has demonstrated that Porphyromonas gulae (P. gulae) significantly contributes to the development of periodontal disease in dogs. Porphyromonas gulae is divided into three subtypes according to the 41-kDa filamentous appendage (fimA), defined as types A, B, and C. This study aimed to elucidate the association between fimA type of P. gulae with the number of permanent teeth, reflecting the severity of periodontal disease. Two hundred twenty-five dogs were categorized by P. gulae fimA type as negative, type A dominant, type B dominant, and type C dominant. The stage of periodontal disease in P. gulae-positive dogs increased with age, particularly in type C dominant dogs. Correspondingly, the number of permanent teeth in P. gulae fimA type C-dominant dogs was significantly lower than that of P. gulae-negative dogs, suggesting there is a significant association between fimA type of P. gulae and the number of permanent teeth resulting from the development of periodontal disease.https://www.frontiersin.org/articles/10.3389/fvets.2023.1022838/fulldogperiodontal diseasePorphyromonas gulaefimA typenumber of permanent teeth |
| spellingShingle | So Shirahata So Shirahata Naoki Iwashita Naoki Iwashita Rie Sasaki Ryota Nomura Masaru Murakami Junya Yasuda Hidemi Yasuda Kuniyasu Nakajima Hiroaki Inaba Michiyo Matsumoto-Nakano Kazuhiko Nakano Jumpei Uchiyama Tomoki Fukuyama Possible association of fimA genotype of Porphyromonas gulae with the severity of periodontal disease and the number of permanent teeth in dogs Frontiers in Veterinary Science dog periodontal disease Porphyromonas gulae fimA type number of permanent teeth |
| title | Possible association of fimA genotype of Porphyromonas gulae with the severity of periodontal disease and the number of permanent teeth in dogs |
| title_full | Possible association of fimA genotype of Porphyromonas gulae with the severity of periodontal disease and the number of permanent teeth in dogs |
| title_fullStr | Possible association of fimA genotype of Porphyromonas gulae with the severity of periodontal disease and the number of permanent teeth in dogs |
| title_full_unstemmed | Possible association of fimA genotype of Porphyromonas gulae with the severity of periodontal disease and the number of permanent teeth in dogs |
| title_short | Possible association of fimA genotype of Porphyromonas gulae with the severity of periodontal disease and the number of permanent teeth in dogs |
| title_sort | possible association of fima genotype of porphyromonas gulae with the severity of periodontal disease and the number of permanent teeth in dogs |
| topic | dog periodontal disease Porphyromonas gulae fimA type number of permanent teeth |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2023.1022838/full |
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