Conductivity reactivity index for monitoring of cerebrovascular autoregulation in early cerebral ischemic rabbits
Abstract Background Cerebrovascular autoregulation (CVAR) is the mechanism that maintains constant cerebral blood flow by adjusting the caliber of the cerebral vessels. It is important to have an effective, contactless way to monitor and assess CVAR in patients with ischemia. Methods The adjustment...
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | BioMedical Engineering OnLine |
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| Online Access: | https://doi.org/10.1186/s12938-023-01142-7 |
| _version_ | 1797557653143027712 |
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| author | Jia Xu Haocheng Li Gui Jin Wei Zhuang Zelin Bai Jian Sun Mingsheng Chen Feng Wang Xu Yang Mingxin Qin |
| author_facet | Jia Xu Haocheng Li Gui Jin Wei Zhuang Zelin Bai Jian Sun Mingsheng Chen Feng Wang Xu Yang Mingxin Qin |
| author_sort | Jia Xu |
| collection | DOAJ |
| description | Abstract Background Cerebrovascular autoregulation (CVAR) is the mechanism that maintains constant cerebral blood flow by adjusting the caliber of the cerebral vessels. It is important to have an effective, contactless way to monitor and assess CVAR in patients with ischemia. Methods The adjustment of cerebral blood flow leads to changes in the conductivity of the whole brain. Here, whole-brain conductivity measured by the magnetic induction phase shift method is a valuable alternative to cerebral blood volume for non-contact assessment of CVAR. Therefore, we proposed the correlation coefficient between spontaneous slow oscillations in arterial blood pressure and the corresponding magnetic induction phase shift as a novel index called the conductivity reactivity index (CRx). In comparison with the intracranial pressure reactivity index (PRx), the feasibility of the conductivity reactivity index to assess CVAR in the early phase of cerebral ischemia has been preliminarily confirmed in animal experiments. Results There was a significant difference in the CRx between the cerebral ischemia group and the control group (p = 0.002). At the same time, there was a significant negative correlation between the CRx and the PRx (r = − 0.642, p = 0.002) after 40 min after ischemia. The Bland–Altman consistency analysis showed that the two indices were linearly related, with a minimal difference and high consistency in the early ischemic period. The sensitivity and specificity of CRx for cerebral ischemia identification were 75% and 20%, respectively, and the area under the ROC curve of CRx was 0.835 (SE = 0.084). Conclusion The animal experimental results preliminarily demonstrated that the CRx can be used to monitor CVAR and identify CVAR injury in early ischemic conditions. The CRx has the potential to be used for contactless, global, bedside, and real-time assessment of CVAR of patients with ischemic stroke. |
| first_indexed | 2024-03-10T17:19:40Z |
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| id | doaj.art-d4bb0bce535041d1bfa59695eb62a153 |
| institution | Directory Open Access Journal |
| issn | 1475-925X |
| language | English |
| last_indexed | 2024-03-10T17:19:40Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BioMedical Engineering OnLine |
| spelling | doaj.art-d4bb0bce535041d1bfa59695eb62a1532023-11-20T10:22:36ZengBMCBioMedical Engineering OnLine1475-925X2023-08-0122111710.1186/s12938-023-01142-7Conductivity reactivity index for monitoring of cerebrovascular autoregulation in early cerebral ischemic rabbitsJia Xu0Haocheng Li1Gui Jin2Wei Zhuang3Zelin Bai4Jian Sun5Mingsheng Chen6Feng Wang7Xu Yang8Mingxin Qin9College of Biomedical Engineering, Third Military Medical University (Army Medical University)College of Biomedical Engineering, Third Military Medical University (Army Medical University)College of Biomedical Engineering, Third Military Medical University (Army Medical University)College of Biomedical Engineering, Third Military Medical University (Army Medical University)College of Biomedical Engineering, Third Military Medical University (Army Medical University)College of Biomedical Engineering, Third Military Medical University (Army Medical University)College of Biomedical Engineering, Third Military Medical University (Army Medical University)College of Biomedical Engineering, Third Military Medical University (Army Medical University)Department of Medical Service, General Hospital of Central Theater CommandCollege of Biomedical Engineering, Third Military Medical University (Army Medical University)Abstract Background Cerebrovascular autoregulation (CVAR) is the mechanism that maintains constant cerebral blood flow by adjusting the caliber of the cerebral vessels. It is important to have an effective, contactless way to monitor and assess CVAR in patients with ischemia. Methods The adjustment of cerebral blood flow leads to changes in the conductivity of the whole brain. Here, whole-brain conductivity measured by the magnetic induction phase shift method is a valuable alternative to cerebral blood volume for non-contact assessment of CVAR. Therefore, we proposed the correlation coefficient between spontaneous slow oscillations in arterial blood pressure and the corresponding magnetic induction phase shift as a novel index called the conductivity reactivity index (CRx). In comparison with the intracranial pressure reactivity index (PRx), the feasibility of the conductivity reactivity index to assess CVAR in the early phase of cerebral ischemia has been preliminarily confirmed in animal experiments. Results There was a significant difference in the CRx between the cerebral ischemia group and the control group (p = 0.002). At the same time, there was a significant negative correlation between the CRx and the PRx (r = − 0.642, p = 0.002) after 40 min after ischemia. The Bland–Altman consistency analysis showed that the two indices were linearly related, with a minimal difference and high consistency in the early ischemic period. The sensitivity and specificity of CRx for cerebral ischemia identification were 75% and 20%, respectively, and the area under the ROC curve of CRx was 0.835 (SE = 0.084). Conclusion The animal experimental results preliminarily demonstrated that the CRx can be used to monitor CVAR and identify CVAR injury in early ischemic conditions. The CRx has the potential to be used for contactless, global, bedside, and real-time assessment of CVAR of patients with ischemic stroke.https://doi.org/10.1186/s12938-023-01142-7Cerebrovascular autoregulationMagnetic induction phase shiftCerebral blood flowConductivity reactivity indexCerebral ischemia |
| spellingShingle | Jia Xu Haocheng Li Gui Jin Wei Zhuang Zelin Bai Jian Sun Mingsheng Chen Feng Wang Xu Yang Mingxin Qin Conductivity reactivity index for monitoring of cerebrovascular autoregulation in early cerebral ischemic rabbits BioMedical Engineering OnLine Cerebrovascular autoregulation Magnetic induction phase shift Cerebral blood flow Conductivity reactivity index Cerebral ischemia |
| title | Conductivity reactivity index for monitoring of cerebrovascular autoregulation in early cerebral ischemic rabbits |
| title_full | Conductivity reactivity index for monitoring of cerebrovascular autoregulation in early cerebral ischemic rabbits |
| title_fullStr | Conductivity reactivity index for monitoring of cerebrovascular autoregulation in early cerebral ischemic rabbits |
| title_full_unstemmed | Conductivity reactivity index for monitoring of cerebrovascular autoregulation in early cerebral ischemic rabbits |
| title_short | Conductivity reactivity index for monitoring of cerebrovascular autoregulation in early cerebral ischemic rabbits |
| title_sort | conductivity reactivity index for monitoring of cerebrovascular autoregulation in early cerebral ischemic rabbits |
| topic | Cerebrovascular autoregulation Magnetic induction phase shift Cerebral blood flow Conductivity reactivity index Cerebral ischemia |
| url | https://doi.org/10.1186/s12938-023-01142-7 |
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