Genetic Inactivation of <i>Notch1</i> Synergizes with Loss of <i>Trp53</i> to Induce Tumor Formation in the Adult Mouse Forebrain

Genetic Inactivation of <i>Notch1</i> Synergizes with Loss of <i>Trp53</i> to Induce Tumor Formation in the Adult Mouse Forebrain

Simultaneous genetic inactivation of the key Notch signaling mediator RBP-Jk and p53 leads to the formation of forebrain tumors in mice, suggesting a tumor suppressor role of the Notch pathway in this context. However, the contribution of individual Notch receptors to the tumor-suppressive activity...

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Bibliographic Details
Main Authors: Elena Parmigiani, Claudio Giachino
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Cancers
Subjects:
Notch signaling
brain tumor
Rbpj
neural progenitor
forebrain
tumor suppressor
Online Access:https://www.mdpi.com/2072-6694/14/21/5409

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