Synthesis and Evaluation of Pyrimidine Steroids as Antiproliferative Agents

Synthesis and Evaluation of Pyrimidine Steroids as Antiproliferative Agents

A small and focused library of steroidal non-fused and fused pyrimidines was prepared from pregnenolone acetate and diosgenin, respectively. The key step was the cycloaddition reaction of nitrogen-containing 1,3-binucleophiles with the steroidal α,β-unsaturated ketone. Urea, thiour...

Full description

Bibliographic Details
Main Authors: Alejandra Cortés-Percino, José Luis Vega-Báez, Anabel Romero-López, Adrián Puerta, Penélope Merino-Montiel, Socorro Meza-Reyes, José M. Padrón, Sara Montiel-Smith
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Molecules
Subjects:
steroids
pyrimidine
heterocycle
cycloaddition reactions
antiproliferative activity
Online Access:https://www.mdpi.com/1420-3049/24/20/3676

Internet

https://www.mdpi.com/1420-3049/24/20/3676

Similar Items