Breed-associated risks for developing canine lymphoma differ among countries: an European canine lymphoma network study
Abstract Background Canine breeds may be considered good animal models for the study of genetic predisposition to cancer, as they represent genetic clusters. From epidemiologic and case collection studies it emerges that some breeds are more likely to develop lymphoma or specific subtypes of lymphom...
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| Format: | Article |
| Language: | English |
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BMC
2018-08-01
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| Series: | BMC Veterinary Research |
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| Online Access: | http://link.springer.com/article/10.1186/s12917-018-1557-2 |
| _version_ | 1818863291484602368 |
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| author | Stefano Comazzi Stefano Marelli Marzia Cozzi Rita Rizzi Riccardo Finotello Joaquim Henriques Josep Pastor Frederique Ponce Carla Rohrer-Bley Barbara C. Rütgen Erik Teske |
| author_facet | Stefano Comazzi Stefano Marelli Marzia Cozzi Rita Rizzi Riccardo Finotello Joaquim Henriques Josep Pastor Frederique Ponce Carla Rohrer-Bley Barbara C. Rütgen Erik Teske |
| author_sort | Stefano Comazzi |
| collection | DOAJ |
| description | Abstract Background Canine breeds may be considered good animal models for the study of genetic predisposition to cancer, as they represent genetic clusters. From epidemiologic and case collection studies it emerges that some breeds are more likely to develop lymphoma or specific subtypes of lymphoma but available data are variable and geographically inconsistent. This study was born in the context of the European Canine Lymphoma Network with the aim of investigating the breed prevalence of canine lymphoma in different European countries and of investigating possible breed risk of lymphoma overall and/or different lymphoma subtypes. Results A total of 1529 canine nodal lymphoma cases and 55,529 control cases from 8 European countries/institutions were retrospectively collected. Odds ratios for lymphoma varied among different countries but Doberman, Rottweiler, boxer and Bernese mountain dogs showed a significant predisposition to lymphoma. In particular, boxers tended to develop T-cell lymphomas (either high- or low-grade) while Rottweilers had a high prevalence of B-cell lymphomas. Labradors were not predisposed to lymphoma overall but tended to develop mainly high-grade T-cell lymphomas. In contrast with previous studies outside of Europe, the European golden retriever population did not show any possible predisposition to lymphoma overall or to specific subtypes such as T-zone lymphoma. Conclusion Further prospective studies with more precise and consistent subtype identification are needed to confirm our retrospective results and to create the basis for the investigation of possible genes involved in different predispositions. |
| first_indexed | 2024-12-19T10:13:26Z |
| format | Article |
| id | doaj.art-d4c125c027574f9abd395196f9e404ea |
| institution | Directory Open Access Journal |
| issn | 1746-6148 |
| language | English |
| last_indexed | 2024-12-19T10:13:26Z |
| publishDate | 2018-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Veterinary Research |
| spelling | doaj.art-d4c125c027574f9abd395196f9e404ea2022-12-21T20:26:17ZengBMCBMC Veterinary Research1746-61482018-08-011411710.1186/s12917-018-1557-2Breed-associated risks for developing canine lymphoma differ among countries: an European canine lymphoma network studyStefano Comazzi0Stefano Marelli1Marzia Cozzi2Rita Rizzi3Riccardo Finotello4Joaquim Henriques5Josep Pastor6Frederique Ponce7Carla Rohrer-Bley8Barbara C. Rütgen9Erik Teske10Department of Veterinary Medicine, University of MilanDepartment of Veterinary Medicine, University of MilanDepartment of Veterinary Medicine, University of MilanDepartment of Veterinary Medicine, University of MilanDepartment of Small Animal Clinical Science, Institute of Veterinary Science, University of LiverpoolHospital Veterinario BernaDepartment of Animal Medicine and Surgery, University Autonoma of BarcelonaDepartment of Internal Medicine, University of LyonDivision of Radiation Oncology, Department of Small Animals, Vetsuisse Faculty, University of ZurichDepartment of Pathobiology, University of Veterinary MedicineDepartment of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht UniversityAbstract Background Canine breeds may be considered good animal models for the study of genetic predisposition to cancer, as they represent genetic clusters. From epidemiologic and case collection studies it emerges that some breeds are more likely to develop lymphoma or specific subtypes of lymphoma but available data are variable and geographically inconsistent. This study was born in the context of the European Canine Lymphoma Network with the aim of investigating the breed prevalence of canine lymphoma in different European countries and of investigating possible breed risk of lymphoma overall and/or different lymphoma subtypes. Results A total of 1529 canine nodal lymphoma cases and 55,529 control cases from 8 European countries/institutions were retrospectively collected. Odds ratios for lymphoma varied among different countries but Doberman, Rottweiler, boxer and Bernese mountain dogs showed a significant predisposition to lymphoma. In particular, boxers tended to develop T-cell lymphomas (either high- or low-grade) while Rottweilers had a high prevalence of B-cell lymphomas. Labradors were not predisposed to lymphoma overall but tended to develop mainly high-grade T-cell lymphomas. In contrast with previous studies outside of Europe, the European golden retriever population did not show any possible predisposition to lymphoma overall or to specific subtypes such as T-zone lymphoma. Conclusion Further prospective studies with more precise and consistent subtype identification are needed to confirm our retrospective results and to create the basis for the investigation of possible genes involved in different predispositions.http://link.springer.com/article/10.1186/s12917-018-1557-2DogLymphomaBreed riskPredispositionOdds ratio |
| spellingShingle | Stefano Comazzi Stefano Marelli Marzia Cozzi Rita Rizzi Riccardo Finotello Joaquim Henriques Josep Pastor Frederique Ponce Carla Rohrer-Bley Barbara C. Rütgen Erik Teske Breed-associated risks for developing canine lymphoma differ among countries: an European canine lymphoma network study BMC Veterinary Research Dog Lymphoma Breed risk Predisposition Odds ratio |
| title | Breed-associated risks for developing canine lymphoma differ among countries: an European canine lymphoma network study |
| title_full | Breed-associated risks for developing canine lymphoma differ among countries: an European canine lymphoma network study |
| title_fullStr | Breed-associated risks for developing canine lymphoma differ among countries: an European canine lymphoma network study |
| title_full_unstemmed | Breed-associated risks for developing canine lymphoma differ among countries: an European canine lymphoma network study |
| title_short | Breed-associated risks for developing canine lymphoma differ among countries: an European canine lymphoma network study |
| title_sort | breed associated risks for developing canine lymphoma differ among countries an european canine lymphoma network study |
| topic | Dog Lymphoma Breed risk Predisposition Odds ratio |
| url | http://link.springer.com/article/10.1186/s12917-018-1557-2 |
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