Catechins: Protective mechanism of antioxidant stress in atherosclerosis
Tea has long been valued for its health benefits, especially its potential to prevent and treat atherosclerosis (AS). Abnormal lipid metabolism and oxidative stress are major factors that contribute to the development of AS. Tea, which originated in China, is believed to help prevent AS. Research ha...
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Format: | Article |
Language: | English |
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Frontiers Media S.A.
2023-03-01
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Series: | Frontiers in Pharmacology |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1144878/full |
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author | Yuhan Sheng Yizhuo Sun Yang Tang Yanru Yu Jiarou Wang Fengjie Zheng Yuhang Li Yan Sun |
author_facet | Yuhan Sheng Yizhuo Sun Yang Tang Yanru Yu Jiarou Wang Fengjie Zheng Yuhang Li Yan Sun |
author_sort | Yuhan Sheng |
collection | DOAJ |
description | Tea has long been valued for its health benefits, especially its potential to prevent and treat atherosclerosis (AS). Abnormal lipid metabolism and oxidative stress are major factors that contribute to the development of AS. Tea, which originated in China, is believed to help prevent AS. Research has shown that tea is rich in catechins, which is considered a potential source of natural antioxidants. Catechins are the most abundant antioxidants in green tea, and are considered to be the main compound responsible for tea’s antioxidant activity. The antioxidant properties of catechins are largely dependent on the structure of molecules, and the number and location of hydroxyl groups or their substituents. As an exogenous antioxidant, catechins can effectively eliminate lipid peroxidation products. They can also play an antioxidant role indirectly by activating the endogenous antioxidant system by regulating enzyme activity and signaling pathways. In this review, we summarized the preventive effect of catechin in AS, and emphasized that improving the antioxidant effect and lipid metabolism disorders of catechins is the key to managing AS. |
first_indexed | 2024-04-09T21:56:49Z |
format | Article |
id | doaj.art-d4c1d5d2fafe40589c3ea146e128f40b |
institution | Directory Open Access Journal |
issn | 1663-9812 |
language | English |
last_indexed | 2024-04-09T21:56:49Z |
publishDate | 2023-03-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Pharmacology |
spelling | doaj.art-d4c1d5d2fafe40589c3ea146e128f40b2023-03-24T04:39:54ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-03-011410.3389/fphar.2023.11448781144878Catechins: Protective mechanism of antioxidant stress in atherosclerosisYuhan ShengYizhuo SunYang TangYanru YuJiarou WangFengjie ZhengYuhang LiYan SunTea has long been valued for its health benefits, especially its potential to prevent and treat atherosclerosis (AS). Abnormal lipid metabolism and oxidative stress are major factors that contribute to the development of AS. Tea, which originated in China, is believed to help prevent AS. Research has shown that tea is rich in catechins, which is considered a potential source of natural antioxidants. Catechins are the most abundant antioxidants in green tea, and are considered to be the main compound responsible for tea’s antioxidant activity. The antioxidant properties of catechins are largely dependent on the structure of molecules, and the number and location of hydroxyl groups or their substituents. As an exogenous antioxidant, catechins can effectively eliminate lipid peroxidation products. They can also play an antioxidant role indirectly by activating the endogenous antioxidant system by regulating enzyme activity and signaling pathways. In this review, we summarized the preventive effect of catechin in AS, and emphasized that improving the antioxidant effect and lipid metabolism disorders of catechins is the key to managing AS.https://www.frontiersin.org/articles/10.3389/fphar.2023.1144878/fullcatechinsoxidative stressatherosclerosislipid metabolism disorderstea |
spellingShingle | Yuhan Sheng Yizhuo Sun Yang Tang Yanru Yu Jiarou Wang Fengjie Zheng Yuhang Li Yan Sun Catechins: Protective mechanism of antioxidant stress in atherosclerosis Frontiers in Pharmacology catechins oxidative stress atherosclerosis lipid metabolism disorders tea |
title | Catechins: Protective mechanism of antioxidant stress in atherosclerosis |
title_full | Catechins: Protective mechanism of antioxidant stress in atherosclerosis |
title_fullStr | Catechins: Protective mechanism of antioxidant stress in atherosclerosis |
title_full_unstemmed | Catechins: Protective mechanism of antioxidant stress in atherosclerosis |
title_short | Catechins: Protective mechanism of antioxidant stress in atherosclerosis |
title_sort | catechins protective mechanism of antioxidant stress in atherosclerosis |
topic | catechins oxidative stress atherosclerosis lipid metabolism disorders tea |
url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1144878/full |
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