Immunoregulatory role of the gut microbiota in inflammatory depression
Abstract Inflammatory depression is a treatment-resistant subtype of depression. A causal role of the gut microbiota as a source of low-grade inflammation remains unclear. Here, as part of an observational trial, we first analyze the gut microbiota composition in the stool, inflammatory factors and...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-47273-w |
| _version_ | 1797209238110470144 |
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| author | Penghong Liu Zhifen Liu Jizhi Wang Junyan Wang Mingxue Gao Yanyan Zhang Chunxia Yang Aixia Zhang Gaizhi Li Xinrong Li Sha Liu Lixin Liu Ning Sun Kerang Zhang |
| author_facet | Penghong Liu Zhifen Liu Jizhi Wang Junyan Wang Mingxue Gao Yanyan Zhang Chunxia Yang Aixia Zhang Gaizhi Li Xinrong Li Sha Liu Lixin Liu Ning Sun Kerang Zhang |
| author_sort | Penghong Liu |
| collection | DOAJ |
| description | Abstract Inflammatory depression is a treatment-resistant subtype of depression. A causal role of the gut microbiota as a source of low-grade inflammation remains unclear. Here, as part of an observational trial, we first analyze the gut microbiota composition in the stool, inflammatory factors and short-chain fatty acids (SCFAs) in plasma, and inflammatory and permeability markers in the intestinal mucosa of patients with inflammatory depression (ChiCTR1900025175). Gut microbiota of patients with inflammatory depression exhibits higher Bacteroides and lower Clostridium, with an increase in SCFA-producing species with abnormal butanoate metabolism. We then perform fecal microbiota transplantation (FMT) and probiotic supplementation in animal experiments to determine the causal role of the gut microbiota in inflammatory depression. After FMT, the gut microbiota of the inflammatory depression group shows increased peripheral and central inflammatory factors and intestinal mucosal permeability in recipient mice with depressive and anxiety-like behaviors. Clostridium butyricum administration normalizes the gut microbiota, decreases inflammatory factors, and displays antidepressant-like effects in a mouse model of inflammatory depression. These findings suggest that inflammatory processes derived from the gut microbiota can be involved in neuroinflammation of inflammatory depression. |
| first_indexed | 2024-04-24T09:51:31Z |
| format | Article |
| id | doaj.art-d4c274ee4c944793b4d0ee888988f624 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-24T09:51:31Z |
| publishDate | 2024-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d4c274ee4c944793b4d0ee888988f6242024-04-14T11:22:29ZengNature PortfolioNature Communications2041-17232024-04-0115111710.1038/s41467-024-47273-wImmunoregulatory role of the gut microbiota in inflammatory depressionPenghong Liu0Zhifen Liu1Jizhi Wang2Junyan Wang3Mingxue Gao4Yanyan Zhang5Chunxia Yang6Aixia Zhang7Gaizhi Li8Xinrong Li9Sha Liu10Lixin Liu11Ning Sun12Kerang Zhang13Department of Psychiatry, First Hospital of Shanxi Medical UniversityDepartment of Psychiatry, First Hospital of Shanxi Medical UniversityDepartment of Psychiatry, First Hospital of Shanxi Medical UniversityDepartment of Psychiatry, First Hospital of Shanxi Medical UniversityDepartment of Psychiatry, First Hospital of Shanxi Medical UniversityDepartment of Psychiatry, First Hospital of Shanxi Medical UniversityDepartment of Psychiatry, First Hospital of Shanxi Medical UniversityDepartment of Psychiatry, First Hospital of Shanxi Medical UniversityDepartment of Psychiatry, First Hospital of Shanxi Medical UniversityDepartment of Psychiatry, First Hospital of Shanxi Medical UniversityDepartment of Psychiatry, First Hospital of Shanxi Medical UniversityExperimental Center of Science and Research, First Hospital of Shanxi Medical UniversityDepartment of Psychiatry, First Hospital of Shanxi Medical UniversityDepartment of Psychiatry, First Hospital of Shanxi Medical UniversityAbstract Inflammatory depression is a treatment-resistant subtype of depression. A causal role of the gut microbiota as a source of low-grade inflammation remains unclear. Here, as part of an observational trial, we first analyze the gut microbiota composition in the stool, inflammatory factors and short-chain fatty acids (SCFAs) in plasma, and inflammatory and permeability markers in the intestinal mucosa of patients with inflammatory depression (ChiCTR1900025175). Gut microbiota of patients with inflammatory depression exhibits higher Bacteroides and lower Clostridium, with an increase in SCFA-producing species with abnormal butanoate metabolism. We then perform fecal microbiota transplantation (FMT) and probiotic supplementation in animal experiments to determine the causal role of the gut microbiota in inflammatory depression. After FMT, the gut microbiota of the inflammatory depression group shows increased peripheral and central inflammatory factors and intestinal mucosal permeability in recipient mice with depressive and anxiety-like behaviors. Clostridium butyricum administration normalizes the gut microbiota, decreases inflammatory factors, and displays antidepressant-like effects in a mouse model of inflammatory depression. These findings suggest that inflammatory processes derived from the gut microbiota can be involved in neuroinflammation of inflammatory depression.https://doi.org/10.1038/s41467-024-47273-w |
| spellingShingle | Penghong Liu Zhifen Liu Jizhi Wang Junyan Wang Mingxue Gao Yanyan Zhang Chunxia Yang Aixia Zhang Gaizhi Li Xinrong Li Sha Liu Lixin Liu Ning Sun Kerang Zhang Immunoregulatory role of the gut microbiota in inflammatory depression Nature Communications |
| title | Immunoregulatory role of the gut microbiota in inflammatory depression |
| title_full | Immunoregulatory role of the gut microbiota in inflammatory depression |
| title_fullStr | Immunoregulatory role of the gut microbiota in inflammatory depression |
| title_full_unstemmed | Immunoregulatory role of the gut microbiota in inflammatory depression |
| title_short | Immunoregulatory role of the gut microbiota in inflammatory depression |
| title_sort | immunoregulatory role of the gut microbiota in inflammatory depression |
| url | https://doi.org/10.1038/s41467-024-47273-w |
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