circDYRK1A tethers biological behaviors of gastric carcinoma using novel bioinformatics analysis and experimental validations
Abstract Gastric cancer has been one of the wide public health burdens with its high morbidity and mortality over several decades. As the unconventional modules among RNA families, circular RNAs present their blazing biological effects during gastric carcinogenesis. Though diverse hypothetical mecha...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-33861-1 |
| _version_ | 1827939935680724992 |
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| author | Zirui Zhu Huiwen Lu Xu Zhao Yimeng Sun Junqiao Yao Chi Xue Baojun Huang |
| author_facet | Zirui Zhu Huiwen Lu Xu Zhao Yimeng Sun Junqiao Yao Chi Xue Baojun Huang |
| author_sort | Zirui Zhu |
| collection | DOAJ |
| description | Abstract Gastric cancer has been one of the wide public health burdens with its high morbidity and mortality over several decades. As the unconventional modules among RNA families, circular RNAs present their blazing biological effects during gastric carcinogenesis. Though diverse hypothetical mechanisms were reported, further tests were necessitated for authentication. Herein, this study pinpointed a representative circDYRK1A which screened from vast amounts of public data sets using surprisingly novel bioinformatics approaches together with validations from the in vitro findings and then concluded that circDYRK1A tethered the biological behavior and swayed the clinicopathological features with gastric cancer patients thus providing an in-depth awareness for gastric carcinoma. |
| first_indexed | 2024-03-13T09:02:04Z |
| format | Article |
| id | doaj.art-d4c3b263215a486bb150fd4cb5a4345e |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-13T09:02:04Z |
| publishDate | 2023-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-d4c3b263215a486bb150fd4cb5a4345e2023-05-28T11:17:39ZengNature PortfolioScientific Reports2045-23222023-05-0113111510.1038/s41598-023-33861-1circDYRK1A tethers biological behaviors of gastric carcinoma using novel bioinformatics analysis and experimental validationsZirui Zhu0Huiwen Lu1Xu Zhao2Yimeng Sun3Junqiao Yao4Chi Xue5Baojun Huang6Department of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors (China Medical University), Ministry of EducationDepartment of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors (China Medical University), Ministry of EducationDepartment of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors (China Medical University), Ministry of EducationDepartment of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors (China Medical University), Ministry of EducationDepartment of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors (China Medical University), Ministry of EducationDepartment of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors (China Medical University), Ministry of EducationDepartment of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors (China Medical University), Ministry of EducationAbstract Gastric cancer has been one of the wide public health burdens with its high morbidity and mortality over several decades. As the unconventional modules among RNA families, circular RNAs present their blazing biological effects during gastric carcinogenesis. Though diverse hypothetical mechanisms were reported, further tests were necessitated for authentication. Herein, this study pinpointed a representative circDYRK1A which screened from vast amounts of public data sets using surprisingly novel bioinformatics approaches together with validations from the in vitro findings and then concluded that circDYRK1A tethered the biological behavior and swayed the clinicopathological features with gastric cancer patients thus providing an in-depth awareness for gastric carcinoma.https://doi.org/10.1038/s41598-023-33861-1 |
| spellingShingle | Zirui Zhu Huiwen Lu Xu Zhao Yimeng Sun Junqiao Yao Chi Xue Baojun Huang circDYRK1A tethers biological behaviors of gastric carcinoma using novel bioinformatics analysis and experimental validations Scientific Reports |
| title | circDYRK1A tethers biological behaviors of gastric carcinoma using novel bioinformatics analysis and experimental validations |
| title_full | circDYRK1A tethers biological behaviors of gastric carcinoma using novel bioinformatics analysis and experimental validations |
| title_fullStr | circDYRK1A tethers biological behaviors of gastric carcinoma using novel bioinformatics analysis and experimental validations |
| title_full_unstemmed | circDYRK1A tethers biological behaviors of gastric carcinoma using novel bioinformatics analysis and experimental validations |
| title_short | circDYRK1A tethers biological behaviors of gastric carcinoma using novel bioinformatics analysis and experimental validations |
| title_sort | circdyrk1a tethers biological behaviors of gastric carcinoma using novel bioinformatics analysis and experimental validations |
| url | https://doi.org/10.1038/s41598-023-33861-1 |
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