Dietary cholesterol absorption, and sterol and bile acid excretion in hypercholesterolemia-resistant white rabbits.
The New Zealand white (NZW) rabbit fed a 0.1% cholesterol-enriched diet (CD) typically responds (normoresponsive, NR) by quickly developing hypercholesterolemia. To study the underlying mechanisms responsible for the widespread phenomenon of inter-individual variability of response to dietary choles...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
1990-11-01
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| Series: | Journal of Lipid Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520422667 |
| _version_ | 1818385585458380800 |
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| author | ML Overturf SA Smith AM Gotto, Jr JD Morrisett T Tewson J Poorman DS Loose-Mitchell |
| author_facet | ML Overturf SA Smith AM Gotto, Jr JD Morrisett T Tewson J Poorman DS Loose-Mitchell |
| author_sort | ML Overturf |
| collection | DOAJ |
| description | The New Zealand white (NZW) rabbit fed a 0.1% cholesterol-enriched diet (CD) typically responds (normoresponsive, NR) by quickly developing hypercholesterolemia. To study the underlying mechanisms responsible for the widespread phenomenon of inter-individual variability of response to dietary cholesterol, a unique hypercholesterolemia-resistant (RT) rabbit model was developed. These animals were utilized to investigate selected potential mechanisms that might enable the RT animal to compensate for dietary cholesterol overload. When rabbits were fed the low-cholesterol stock diet, there was no significant difference in the plasma cholesterol concentrations of the NR and the RT animals. However, a significant rise was observed in the NR rabbits within 1 month of their being placed on the cholesterol-enriched diet; the plasma cholesterol concentration of the RT animals was not affected. During consumption of the cholesterol diet the cholesterol absorption rate was somewhat greater in the NR rabbits (P less than 0.05), whereas intestinal transit times and the fecal excretion of neutral steroids were substantially the same in both groups. In contrast, the fecal bile acid excretion of the RT animals was more than twice as great (P less than 0.0001) as that of the NR animals. We conclude that the response to dietary cholesterol is a heritable trait in these rabbits and that, although less dietary cholesterol was absorbed by the RT animals, it appears that a major mechanism controlling plasma cholesterol levels involves the rate of conversion of cholesterol to bile acids and their subsequent excretion. |
| first_indexed | 2024-12-14T03:40:30Z |
| format | Article |
| id | doaj.art-d4c69bf8acce4ed5a9ee8a42533d3c3c |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-14T03:40:30Z |
| publishDate | 1990-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-d4c69bf8acce4ed5a9ee8a42533d3c3c2022-12-21T23:18:30ZengElsevierJournal of Lipid Research0022-22751990-11-01311120192027Dietary cholesterol absorption, and sterol and bile acid excretion in hypercholesterolemia-resistant white rabbits.ML Overturf0SA Smith1AM Gotto, Jr2JD Morrisett3T Tewson4J Poorman5DS Loose-Mitchell6Department of Medicine, University of Texas Medical School, Houston 77030.Department of Medicine, University of Texas Medical School, Houston 77030.Department of Medicine, University of Texas Medical School, Houston 77030.Department of Medicine, University of Texas Medical School, Houston 77030.Department of Medicine, University of Texas Medical School, Houston 77030.Department of Medicine, University of Texas Medical School, Houston 77030.Department of Medicine, University of Texas Medical School, Houston 77030.The New Zealand white (NZW) rabbit fed a 0.1% cholesterol-enriched diet (CD) typically responds (normoresponsive, NR) by quickly developing hypercholesterolemia. To study the underlying mechanisms responsible for the widespread phenomenon of inter-individual variability of response to dietary cholesterol, a unique hypercholesterolemia-resistant (RT) rabbit model was developed. These animals were utilized to investigate selected potential mechanisms that might enable the RT animal to compensate for dietary cholesterol overload. When rabbits were fed the low-cholesterol stock diet, there was no significant difference in the plasma cholesterol concentrations of the NR and the RT animals. However, a significant rise was observed in the NR rabbits within 1 month of their being placed on the cholesterol-enriched diet; the plasma cholesterol concentration of the RT animals was not affected. During consumption of the cholesterol diet the cholesterol absorption rate was somewhat greater in the NR rabbits (P less than 0.05), whereas intestinal transit times and the fecal excretion of neutral steroids were substantially the same in both groups. In contrast, the fecal bile acid excretion of the RT animals was more than twice as great (P less than 0.0001) as that of the NR animals. We conclude that the response to dietary cholesterol is a heritable trait in these rabbits and that, although less dietary cholesterol was absorbed by the RT animals, it appears that a major mechanism controlling plasma cholesterol levels involves the rate of conversion of cholesterol to bile acids and their subsequent excretion.http://www.sciencedirect.com/science/article/pii/S0022227520422667 |
| spellingShingle | ML Overturf SA Smith AM Gotto, Jr JD Morrisett T Tewson J Poorman DS Loose-Mitchell Dietary cholesterol absorption, and sterol and bile acid excretion in hypercholesterolemia-resistant white rabbits. Journal of Lipid Research |
| title | Dietary cholesterol absorption, and sterol and bile acid excretion in hypercholesterolemia-resistant white rabbits. |
| title_full | Dietary cholesterol absorption, and sterol and bile acid excretion in hypercholesterolemia-resistant white rabbits. |
| title_fullStr | Dietary cholesterol absorption, and sterol and bile acid excretion in hypercholesterolemia-resistant white rabbits. |
| title_full_unstemmed | Dietary cholesterol absorption, and sterol and bile acid excretion in hypercholesterolemia-resistant white rabbits. |
| title_short | Dietary cholesterol absorption, and sterol and bile acid excretion in hypercholesterolemia-resistant white rabbits. |
| title_sort | dietary cholesterol absorption and sterol and bile acid excretion in hypercholesterolemia resistant white rabbits |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520422667 |
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