The antioxidant status of coenzyme Q10 and vitamin E in children with type 1 diabetes
Objective: The purpose of this study was to evaluate the antioxidant status of plasma vitamin E and plasma and intracellular coenzyme Q10 in children with type 1 diabetes. Method: This case–control study was conducted on 72 children with type 1 diabetes and compared to 48 healthy children, who were...
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| Format: | Article |
| Language: | Portuguese |
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Brazilian Society of Pediatrics
2019-03-01
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| Series: | Jornal de Pediatria (Versão em Português) |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2255553618300326 |
| _version_ | 1797984504753684480 |
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| author | Usama M. Alkholy Nermin Abdalmonem Ahmed Zaki Mohamed A. Elkoumi Mustafa I. Abu Hashim Maha A.A. Basset Hossam E. Salah |
| author_facet | Usama M. Alkholy Nermin Abdalmonem Ahmed Zaki Mohamed A. Elkoumi Mustafa I. Abu Hashim Maha A.A. Basset Hossam E. Salah |
| author_sort | Usama M. Alkholy |
| collection | DOAJ |
| description | Objective: The purpose of this study was to evaluate the antioxidant status of plasma vitamin E and plasma and intracellular coenzyme Q10 in children with type 1 diabetes. Method: This case–control study was conducted on 72 children with type 1 diabetes and compared to 48 healthy children, who were age, sex, and ethnicity‐matched. The diabetic children were divided according to their glycosylated hemoglobin (A1c %) into two groups: poor and good glycemic control groups. All children underwent full history taking, clinical examination, and laboratory measurement of complete blood count, A1c %, plasma cholesterol, triglycerides, and vitamin E levels and coenzyme Q10 levels in plasma, erythrocytes, and platelets. Results: Children with poor glycemic control showed significantly higher plasma vitamin E, coenzyme Q10, triglycerides, low‐density lipoproteins, waist circumference/height ratio, cholesterol levels, and lower high‐density lipoproteins and platelet coenzyme Q10 redox status in comparison to those with good glycemic control and the control group (p < 0.05). Plasma coenzyme Q10 showed a positive correlation with the duration of type 1 diabetes, triglycerides, cholesterol, vitamin E, and A1c %, and negative correlation with the age of the diabetic group (p < 0.05). The platelet redox status showed a negative correlation with the A1c % levels (r = −0.31; p = 0.022) and the duration of type 1 diabetes (r = −0.35, p = 0.012). Conclusion: Patients with type 1 diabetes, especially poorly controlled, had elevation of plasma vitamin E and coenzyme Q10 levels and decreased platelet redox status of coenzyme Q10, which may be an indicator of increased oxidative stress. Resumo: Objetivo: Avaliar o estado antioxidante da vitamina E no plasma e da coenzima Q10 no plasma e intracelular em crianças com diabetes tipo 1. Método: Este estudo caso‐controle realizado em com 72 crianças com diabetes tipo 1 comparadas por idade, sexo e etnia de 58 crianças saudáveis. As crianças diabéticas foram divididas em dois grupos de acordo com sua hemoglobina glicosilada (A1c %): grupos de controle glicêmico bom e baixo. Todas as crianças foram submetidas a anamnese total, exame clínico e laboratorial para hemograma completo, A1c %, colesterol no plasma, triglicerídeos e níveis de vitamina E e níveis de coenzima Q10 no plasma, eritrócitos e plaquetas. Resultados: As crianças com baixo controle glicêmico mostraram nível de vitamina E no plasma significativamente maior, coenzima Q10, triglicerídeos, lipoproteína de baixa densidade, proporção da circunferência da cintura/estatura e níveis de colesterol e menor nível de lipoproteína de alta densidade e estado redox da coenzima Q10 em comparação aos com bom controle glicêmico e com o grupo de controle (p < 0,05). A coenzima Q10 no plasma mostrou correlação positiva com a duração da diabetes tipo 1, triglicerídeos, colesterol, vitamina E e A1c % e correlação negativa com a idade do grupo diabético (p < 0,05). O estado redox das plaquetas mostrou correlação negativa com os níveis de A1c % (r = ‐0,31; p = 0,022) e a duração da diabetes tipo 1 (r = ‐0,35, p = 0,012). Conclusão: Os pacientes com diabetes tipo 1, principalmente mal controlados, apresentaram aumento nos níveis de vitamina E no plasma e coenzima Q10 e redução no estado redox das plaquetas da coenzima Q10 que podem indicar aumento do estresse oxidativo. Keywords: Type 1 diabetes, Oxidative stress, Vitamin E, Coenzyme Q10, Palavras‐chave: Diabetes tipo 1, Estresse oxidativo, Vitamina E, Coenzima Q10 |
| first_indexed | 2024-04-11T07:03:53Z |
| format | Article |
| id | doaj.art-d4c6ca254d4d4c94816ca0fff71c5a0f |
| institution | Directory Open Access Journal |
| issn | 2255-5536 |
| language | Portuguese |
| last_indexed | 2024-04-11T07:03:53Z |
| publishDate | 2019-03-01 |
| publisher | Brazilian Society of Pediatrics |
| record_format | Article |
| series | Jornal de Pediatria (Versão em Português) |
| spelling | doaj.art-d4c6ca254d4d4c94816ca0fff71c5a0f2022-12-22T04:38:34ZporBrazilian Society of PediatricsJornal de Pediatria (Versão em Português)2255-55362019-03-01952224230The antioxidant status of coenzyme Q10 and vitamin E in children with type 1 diabetesUsama M. Alkholy0Nermin Abdalmonem1Ahmed Zaki2Mohamed A. Elkoumi3Mustafa I. Abu Hashim4Maha A.A. Basset5Hossam E. Salah6Zagazig University, Faculty of Medicine, Pediatric Department, Sharkia, Egito; Autor para correspondência.Zagazig University, Faculty of Medicine, Pediatric Department, Sharkia, EgitoMansoura University, Faculty of Medicine, Pediatric Department, Mansoura, EgitoZagazig University, Faculty of Medicine, Pediatric Department, Sharkia, EgitoZagazig University, Faculty of Medicine, Pediatric Department, Sharkia, EgitoZagazig University, Faculty of Medicine, Pediatric Department, Sharkia, EgitoZagazig University, Faculty of Medicine, Clinical Pathology Department, Sharkia, EgitoObjective: The purpose of this study was to evaluate the antioxidant status of plasma vitamin E and plasma and intracellular coenzyme Q10 in children with type 1 diabetes. Method: This case–control study was conducted on 72 children with type 1 diabetes and compared to 48 healthy children, who were age, sex, and ethnicity‐matched. The diabetic children were divided according to their glycosylated hemoglobin (A1c %) into two groups: poor and good glycemic control groups. All children underwent full history taking, clinical examination, and laboratory measurement of complete blood count, A1c %, plasma cholesterol, triglycerides, and vitamin E levels and coenzyme Q10 levels in plasma, erythrocytes, and platelets. Results: Children with poor glycemic control showed significantly higher plasma vitamin E, coenzyme Q10, triglycerides, low‐density lipoproteins, waist circumference/height ratio, cholesterol levels, and lower high‐density lipoproteins and platelet coenzyme Q10 redox status in comparison to those with good glycemic control and the control group (p < 0.05). Plasma coenzyme Q10 showed a positive correlation with the duration of type 1 diabetes, triglycerides, cholesterol, vitamin E, and A1c %, and negative correlation with the age of the diabetic group (p < 0.05). The platelet redox status showed a negative correlation with the A1c % levels (r = −0.31; p = 0.022) and the duration of type 1 diabetes (r = −0.35, p = 0.012). Conclusion: Patients with type 1 diabetes, especially poorly controlled, had elevation of plasma vitamin E and coenzyme Q10 levels and decreased platelet redox status of coenzyme Q10, which may be an indicator of increased oxidative stress. Resumo: Objetivo: Avaliar o estado antioxidante da vitamina E no plasma e da coenzima Q10 no plasma e intracelular em crianças com diabetes tipo 1. Método: Este estudo caso‐controle realizado em com 72 crianças com diabetes tipo 1 comparadas por idade, sexo e etnia de 58 crianças saudáveis. As crianças diabéticas foram divididas em dois grupos de acordo com sua hemoglobina glicosilada (A1c %): grupos de controle glicêmico bom e baixo. Todas as crianças foram submetidas a anamnese total, exame clínico e laboratorial para hemograma completo, A1c %, colesterol no plasma, triglicerídeos e níveis de vitamina E e níveis de coenzima Q10 no plasma, eritrócitos e plaquetas. Resultados: As crianças com baixo controle glicêmico mostraram nível de vitamina E no plasma significativamente maior, coenzima Q10, triglicerídeos, lipoproteína de baixa densidade, proporção da circunferência da cintura/estatura e níveis de colesterol e menor nível de lipoproteína de alta densidade e estado redox da coenzima Q10 em comparação aos com bom controle glicêmico e com o grupo de controle (p < 0,05). A coenzima Q10 no plasma mostrou correlação positiva com a duração da diabetes tipo 1, triglicerídeos, colesterol, vitamina E e A1c % e correlação negativa com a idade do grupo diabético (p < 0,05). O estado redox das plaquetas mostrou correlação negativa com os níveis de A1c % (r = ‐0,31; p = 0,022) e a duração da diabetes tipo 1 (r = ‐0,35, p = 0,012). Conclusão: Os pacientes com diabetes tipo 1, principalmente mal controlados, apresentaram aumento nos níveis de vitamina E no plasma e coenzima Q10 e redução no estado redox das plaquetas da coenzima Q10 que podem indicar aumento do estresse oxidativo. Keywords: Type 1 diabetes, Oxidative stress, Vitamin E, Coenzyme Q10, Palavras‐chave: Diabetes tipo 1, Estresse oxidativo, Vitamina E, Coenzima Q10http://www.sciencedirect.com/science/article/pii/S2255553618300326 |
| spellingShingle | Usama M. Alkholy Nermin Abdalmonem Ahmed Zaki Mohamed A. Elkoumi Mustafa I. Abu Hashim Maha A.A. Basset Hossam E. Salah The antioxidant status of coenzyme Q10 and vitamin E in children with type 1 diabetes Jornal de Pediatria (Versão em Português) |
| title | The antioxidant status of coenzyme Q10 and vitamin E in children with type 1 diabetes |
| title_full | The antioxidant status of coenzyme Q10 and vitamin E in children with type 1 diabetes |
| title_fullStr | The antioxidant status of coenzyme Q10 and vitamin E in children with type 1 diabetes |
| title_full_unstemmed | The antioxidant status of coenzyme Q10 and vitamin E in children with type 1 diabetes |
| title_short | The antioxidant status of coenzyme Q10 and vitamin E in children with type 1 diabetes |
| title_sort | antioxidant status of coenzyme q10 and vitamin e in children with type 1 diabetes |
| url | http://www.sciencedirect.com/science/article/pii/S2255553618300326 |
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