Matrix stiffness and architecture drive fibro-adipogenic progenitors’ activation into myofibroblasts

Matrix stiffness and architecture drive fibro-adipogenic progenitors’ activation into myofibroblasts

Abstract Fibro-adipogenic progenitors (FAPs) are essential in supporting regeneration in skeletal muscle, but in muscle pathologies FAPs the are main source of excess extracellular matrix (ECM) resulting in fibrosis. Fibrotic ECM has altered mechanical and architectural properties, but the feedback...

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Bibliographic Details
Main Authors: Taryn Loomis, Lin-Ya Hu, Ross P. Wohlgemuth, Rosemary R. Chellakudam, Pooja D. Muralidharan, Lucas R. Smith
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-17852-2

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