Visfatin expression in gingival tissues of chronic periodontitis and aggressive periodontitis patients: An immunohistochemical analysis
Background: Visfatin, also known as nicotinamide phosphoribosyltransferase, has been suggested as a pro-inflammatory and immunomodulating marker for periodontitis. The aim of this study was an immunohistochemical analysis of visfatin in gingival tissues of patients with chronic periodontitis and agg...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Dental Research Journal |
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| Online Access: | http://www.drjjournal.net/article.asp?issn=1735-3327;year=2018;volume=15;issue=2;spage=104;epage=110;aulast=Tabari |
| _version_ | 1828462771128238080 |
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| author | Zahra Alizadeh Tabari Forooz Keshani Majid Sharbatdaran Amirhossein Banishahabadi Marziyeh Nejatifard Hossein Ghorbani |
| author_facet | Zahra Alizadeh Tabari Forooz Keshani Majid Sharbatdaran Amirhossein Banishahabadi Marziyeh Nejatifard Hossein Ghorbani |
| author_sort | Zahra Alizadeh Tabari |
| collection | DOAJ |
| description | Background: Visfatin, also known as nicotinamide phosphoribosyltransferase, has been suggested as a pro-inflammatory and immunomodulating marker for periodontitis. The aim of this study was an immunohistochemical analysis of visfatin in gingival tissues of patients with chronic periodontitis and aggressive periodontitis.
Materials and Methods: In this cross-sectional study based on clinical evaluation and inclusion and exclusion criteria. Twenty patients with generalized chronic periodontitis, 13 patients with generalized aggressive periodontitis, and 20 periodontally healthy individuals enrolled. Gingival tissue samples were obtained during periodontal flap surgery and crown lengthening surgery in periodontal patients and healthy group, respectively. Tissue samples were transferred to a pathology laboratory to determine the degree of inflammatory infiltration by hematoxylin and eosin staining and the level of visfatin expression by immunohistochemistry. The data were analyzed using SPSS version 20 statistical software and paired t-test, Mann–Whitney test, and Spearman rank correlation coefficient. P < 0.05 was considered statistically significant.
Results: Inflammation grading and visfatin expression were significantly higher in periodontally diseased gingiva compared to the control group (P < 0.05). However, no significant difference was found between two diseased groups. The relationship between inflammation grading and visfatin expression in aggressive periodontitis group was statistically significant, positive and relatively strong (P = 0.025, r = 0.617). However, no significant relationship has been found between visfatin expression and inflammation grading in the chronic periodontitits and control groups (P > 0.05).
Conclusion: Visfatin expression was increased in gingival tissues of chronic periodontitis and aggressive periodontitis patients. Hence, visfatin may have a role in the etiopathogenesis of chronic periodontitis and aggressive periodontitis. |
| first_indexed | 2024-12-11T02:41:36Z |
| format | Article |
| id | doaj.art-d4c98365046045a2a3a2339290fefc26 |
| institution | Directory Open Access Journal |
| issn | 1735-3327 2008-0255 |
| language | English |
| last_indexed | 2024-12-11T02:41:36Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Dental Research Journal |
| spelling | doaj.art-d4c98365046045a2a3a2339290fefc262022-12-22T01:23:33ZengWolters Kluwer Medknow PublicationsDental Research Journal1735-33272008-02552018-01-0115210411010.4103/1735-3327.226528Visfatin expression in gingival tissues of chronic periodontitis and aggressive periodontitis patients: An immunohistochemical analysisZahra Alizadeh TabariForooz KeshaniMajid SharbatdaranAmirhossein BanishahabadiMarziyeh NejatifardHossein GhorbaniBackground: Visfatin, also known as nicotinamide phosphoribosyltransferase, has been suggested as a pro-inflammatory and immunomodulating marker for periodontitis. The aim of this study was an immunohistochemical analysis of visfatin in gingival tissues of patients with chronic periodontitis and aggressive periodontitis. Materials and Methods: In this cross-sectional study based on clinical evaluation and inclusion and exclusion criteria. Twenty patients with generalized chronic periodontitis, 13 patients with generalized aggressive periodontitis, and 20 periodontally healthy individuals enrolled. Gingival tissue samples were obtained during periodontal flap surgery and crown lengthening surgery in periodontal patients and healthy group, respectively. Tissue samples were transferred to a pathology laboratory to determine the degree of inflammatory infiltration by hematoxylin and eosin staining and the level of visfatin expression by immunohistochemistry. The data were analyzed using SPSS version 20 statistical software and paired t-test, Mann–Whitney test, and Spearman rank correlation coefficient. P < 0.05 was considered statistically significant. Results: Inflammation grading and visfatin expression were significantly higher in periodontally diseased gingiva compared to the control group (P < 0.05). However, no significant difference was found between two diseased groups. The relationship between inflammation grading and visfatin expression in aggressive periodontitis group was statistically significant, positive and relatively strong (P = 0.025, r = 0.617). However, no significant relationship has been found between visfatin expression and inflammation grading in the chronic periodontitits and control groups (P > 0.05). Conclusion: Visfatin expression was increased in gingival tissues of chronic periodontitis and aggressive periodontitis patients. Hence, visfatin may have a role in the etiopathogenesis of chronic periodontitis and aggressive periodontitis.http://www.drjjournal.net/article.asp?issn=1735-3327;year=2018;volume=15;issue=2;spage=104;epage=110;aulast=TabariAggressive periodontitischronic periodontitisimmunohistochemistryvisfatin |
| spellingShingle | Zahra Alizadeh Tabari Forooz Keshani Majid Sharbatdaran Amirhossein Banishahabadi Marziyeh Nejatifard Hossein Ghorbani Visfatin expression in gingival tissues of chronic periodontitis and aggressive periodontitis patients: An immunohistochemical analysis Dental Research Journal Aggressive periodontitis chronic periodontitis immunohistochemistry visfatin |
| title | Visfatin expression in gingival tissues of chronic periodontitis and aggressive periodontitis patients: An immunohistochemical analysis |
| title_full | Visfatin expression in gingival tissues of chronic periodontitis and aggressive periodontitis patients: An immunohistochemical analysis |
| title_fullStr | Visfatin expression in gingival tissues of chronic periodontitis and aggressive periodontitis patients: An immunohistochemical analysis |
| title_full_unstemmed | Visfatin expression in gingival tissues of chronic periodontitis and aggressive periodontitis patients: An immunohistochemical analysis |
| title_short | Visfatin expression in gingival tissues of chronic periodontitis and aggressive periodontitis patients: An immunohistochemical analysis |
| title_sort | visfatin expression in gingival tissues of chronic periodontitis and aggressive periodontitis patients an immunohistochemical analysis |
| topic | Aggressive periodontitis chronic periodontitis immunohistochemistry visfatin |
| url | http://www.drjjournal.net/article.asp?issn=1735-3327;year=2018;volume=15;issue=2;spage=104;epage=110;aulast=Tabari |
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