How Genetics and Genomics Advances Are Rewriting Pediatric Cancer Research and Clinical Care
In the last two decades, thanks to the data that have been obtained from the Human Genome Project and the development of next-generation sequencing (NGS) technologies, research in oncology has produced extremely important results in understanding the genomic landscape of pediatric cancers, which are...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/58/10/1386 |
| _version_ | 1827649058571812864 |
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| author | Selene Cipri Ludovico Abenavoli Luigi Boccuto Giada Del Baldo Angela Mastronuzzi |
| author_facet | Selene Cipri Ludovico Abenavoli Luigi Boccuto Giada Del Baldo Angela Mastronuzzi |
| author_sort | Selene Cipri |
| collection | DOAJ |
| description | In the last two decades, thanks to the data that have been obtained from the Human Genome Project and the development of next-generation sequencing (NGS) technologies, research in oncology has produced extremely important results in understanding the genomic landscape of pediatric cancers, which are the main cause of death during childhood. NGS has provided significant advances in medicine by detecting germline and somatic driver variants that determine the development and progression of many types of cancers, allowing a distinction between hereditary and non-hereditary cancers, characterizing resistance mechanisms that are also related to alterations of the epigenetic apparatus, and quantifying the mutational burden of tumor cells. A combined approach of next-generation technologies allows us to investigate the numerous molecular features of the cancer cell and the effects of the environment on it, discovering and following the path of personalized therapy to defeat an “ancient” disease that has had victories and defeats. In this paper, we provide an overview of the results that have been obtained in the last decade from genomic studies that were carried out on pediatric cancer and their contribution to the more accurate and faster diagnosis in the stratification of patients and the development of new precision therapies. |
| first_indexed | 2024-03-09T19:51:36Z |
| format | Article |
| id | doaj.art-d4c98d8b5f514fe0ac7c29ba21bf151f |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T19:51:36Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-d4c98d8b5f514fe0ac7c29ba21bf151f2023-11-24T01:10:13ZengMDPI AGMedicina1010-660X1648-91442022-10-015810138610.3390/medicina58101386How Genetics and Genomics Advances Are Rewriting Pediatric Cancer Research and Clinical CareSelene Cipri0Ludovico Abenavoli1Luigi Boccuto2Giada Del Baldo3Angela Mastronuzzi4Department of Hematology/Oncology, Cell Therapy, Gene Therapies and Hemopoietic Transplant, Bambino Gesù Children’s Hospital, 00165 Rome, ItalyDepartment of Health Sciences, University Magna Graecia, 88100 Catanzaro, ItalyHealthcare Genetics Program, School of Nursing, College of Behavioral, Social and Health Sciences, Clemson University, Clemson, SC 29634, USADepartment of Hematology/Oncology, Cell Therapy, Gene Therapies and Hemopoietic Transplant, Bambino Gesù Children’s Hospital, 00165 Rome, ItalyDepartment of Hematology/Oncology, Cell Therapy, Gene Therapies and Hemopoietic Transplant, Bambino Gesù Children’s Hospital, 00165 Rome, ItalyIn the last two decades, thanks to the data that have been obtained from the Human Genome Project and the development of next-generation sequencing (NGS) technologies, research in oncology has produced extremely important results in understanding the genomic landscape of pediatric cancers, which are the main cause of death during childhood. NGS has provided significant advances in medicine by detecting germline and somatic driver variants that determine the development and progression of many types of cancers, allowing a distinction between hereditary and non-hereditary cancers, characterizing resistance mechanisms that are also related to alterations of the epigenetic apparatus, and quantifying the mutational burden of tumor cells. A combined approach of next-generation technologies allows us to investigate the numerous molecular features of the cancer cell and the effects of the environment on it, discovering and following the path of personalized therapy to defeat an “ancient” disease that has had victories and defeats. In this paper, we provide an overview of the results that have been obtained in the last decade from genomic studies that were carried out on pediatric cancer and their contribution to the more accurate and faster diagnosis in the stratification of patients and the development of new precision therapies.https://www.mdpi.com/1648-9144/58/10/1386pediatric cancerHuman Genome Projectnext-generation sequencingpersonalized medicinecancer predisposition syndromes |
| spellingShingle | Selene Cipri Ludovico Abenavoli Luigi Boccuto Giada Del Baldo Angela Mastronuzzi How Genetics and Genomics Advances Are Rewriting Pediatric Cancer Research and Clinical Care Medicina pediatric cancer Human Genome Project next-generation sequencing personalized medicine cancer predisposition syndromes |
| title | How Genetics and Genomics Advances Are Rewriting Pediatric Cancer Research and Clinical Care |
| title_full | How Genetics and Genomics Advances Are Rewriting Pediatric Cancer Research and Clinical Care |
| title_fullStr | How Genetics and Genomics Advances Are Rewriting Pediatric Cancer Research and Clinical Care |
| title_full_unstemmed | How Genetics and Genomics Advances Are Rewriting Pediatric Cancer Research and Clinical Care |
| title_short | How Genetics and Genomics Advances Are Rewriting Pediatric Cancer Research and Clinical Care |
| title_sort | how genetics and genomics advances are rewriting pediatric cancer research and clinical care |
| topic | pediatric cancer Human Genome Project next-generation sequencing personalized medicine cancer predisposition syndromes |
| url | https://www.mdpi.com/1648-9144/58/10/1386 |
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