Neopterin, soluble adhesion molecules and soluble cytokine receptors correlate with disease activity in rheumatoid arthritis
Serum concentrations of soluble intercellular adhesion molecules, sICAM-I , sICAM-3 and sP-selectin, of serum soluble cytokine receptors, sIL-2R, and sTNF-R55 and of neopterin were measured by commercially available immunoassays in 35 patients with rheumatoid arthritis (RA). Serum sICAM-I, sICAM-3 a...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2000-05-01
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| Series: | Pteridines |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/pteridines.2000.11.2.54 |
| _version_ | 1819102124025315328 |
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| author | Nassonov El Samsonov My Tilz Gp Chichasova Ny Widner B Demel U Nikiphorova El Fuchs D |
| author_facet | Nassonov El Samsonov My Tilz Gp Chichasova Ny Widner B Demel U Nikiphorova El Fuchs D |
| author_sort | Nassonov El |
| collection | DOAJ |
| description | Serum concentrations of soluble intercellular adhesion molecules, sICAM-I , sICAM-3 and sP-selectin, of serum soluble cytokine receptors, sIL-2R, and sTNF-R55 and of neopterin were measured by commercially available immunoassays in 35 patients with rheumatoid arthritis (RA). Serum sICAM-I, sICAM-3 and sPselectin were significantly elevated in patients with RA compared with healthy controls. Concentrations of sPselectin and sICAM-3 correlated with disease activity and severity indices. sICAM-3 levels significantly correlated with sTNF-R55 and neopterin. There were significant correlations between neopterin and sIL-2R and between sTNF-R55 and sIL-2R. The measurement of sP-selectin and sICAM-3 levels in patients with RA might become useful for monitoring disease activity. |
| first_indexed | 2024-12-22T01:29:34Z |
| format | Article |
| id | doaj.art-d4c9df8f009b43a1a7e19a3cc8c61f7a |
| institution | Directory Open Access Journal |
| issn | 0933-4807 2195-4720 |
| language | English |
| last_indexed | 2024-12-22T01:29:34Z |
| publishDate | 2000-05-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Pteridines |
| spelling | doaj.art-d4c9df8f009b43a1a7e19a3cc8c61f7a2022-12-21T18:43:31ZengDe GruyterPteridines0933-48072195-47202000-05-01112545910.1515/pteridines.2000.11.2.54Neopterin, soluble adhesion molecules and soluble cytokine receptors correlate with disease activity in rheumatoid arthritisNassonov El0Samsonov My1Tilz Gp2Chichasova Ny3Widner B4Demel U5Nikiphorova El6Fuchs D7Department of Rheumatology, Moscow Medical Academy , Moscow, RussiaDepartment of Rheumatology, Moscow Medical Academy , Moscow, RussiaDepartment of Internal Medicine, University of Graz, GrazDepartment of Rheumatology, Moscow Medical Academy , Moscow, RussiaInstitute of Medical Chemistry and Biochemistry, University of Innsbruck, Innsbruck, AustriaDepartment of Internal Medicine, University of Graz, GrazDepartment of Rheumatology, Moscow Medical Academy , Moscow, RussiaInstitute of Medical Chemistry and Biochemistry, University of Innsbruck, Innsbruck, AustriaSerum concentrations of soluble intercellular adhesion molecules, sICAM-I , sICAM-3 and sP-selectin, of serum soluble cytokine receptors, sIL-2R, and sTNF-R55 and of neopterin were measured by commercially available immunoassays in 35 patients with rheumatoid arthritis (RA). Serum sICAM-I, sICAM-3 and sPselectin were significantly elevated in patients with RA compared with healthy controls. Concentrations of sPselectin and sICAM-3 correlated with disease activity and severity indices. sICAM-3 levels significantly correlated with sTNF-R55 and neopterin. There were significant correlations between neopterin and sIL-2R and between sTNF-R55 and sIL-2R. The measurement of sP-selectin and sICAM-3 levels in patients with RA might become useful for monitoring disease activity.https://doi.org/10.1515/pteridines.2000.11.2.54rheumatoid arthritissoluble cytokine receptorsneopterin |
| spellingShingle | Nassonov El Samsonov My Tilz Gp Chichasova Ny Widner B Demel U Nikiphorova El Fuchs D Neopterin, soluble adhesion molecules and soluble cytokine receptors correlate with disease activity in rheumatoid arthritis Pteridines rheumatoid arthritis soluble cytokine receptors neopterin |
| title | Neopterin, soluble adhesion molecules and soluble cytokine receptors correlate with disease activity in rheumatoid arthritis |
| title_full | Neopterin, soluble adhesion molecules and soluble cytokine receptors correlate with disease activity in rheumatoid arthritis |
| title_fullStr | Neopterin, soluble adhesion molecules and soluble cytokine receptors correlate with disease activity in rheumatoid arthritis |
| title_full_unstemmed | Neopterin, soluble adhesion molecules and soluble cytokine receptors correlate with disease activity in rheumatoid arthritis |
| title_short | Neopterin, soluble adhesion molecules and soluble cytokine receptors correlate with disease activity in rheumatoid arthritis |
| title_sort | neopterin soluble adhesion molecules and soluble cytokine receptors correlate with disease activity in rheumatoid arthritis |
| topic | rheumatoid arthritis soluble cytokine receptors neopterin |
| url | https://doi.org/10.1515/pteridines.2000.11.2.54 |
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